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Application of Six Sigma Metrics to Improve Quality Control for Point-of-care Glucose Testing

Park S, Lee W, Jeong TD, Chung HS, Hong KS

Objectives: Six sigma is a quality management system for the assessment of precisionand accuracy. We aim to apply the six sigma rule to quality control (QC) of point-of-care(POC) glucose meters...
KSNR Clinical Consensus Statements: Rehabilitation of Patients with Parkinson's Disease

KSNR PD Writing Group, Kim DY, Oh HM, Bok SK, Chang WH, Choi Y, Chun MH, Han SJ, Han TR, Jee S, Jung SH, Jung HY, Jung TD, Kim MW, Kim EJ, Kim HS, Kim YH, Kim Y, Kim DY, Kim DY, Kim DK, Ko SH, Ko MH, Lee JK, Lee J, Lee SJ, Lee SG, Lim SH, Oh BM, Paik NJ, Park KD, Park SW, Park GY, Park JH, Park YG, Pyun SB, Ryu B, Seo HG, Shin YI, Sohn MK, Yang SN, Yoo SD, Yoo WK

Clinical consensus statements (CCSs) aim to improve care for patients with Parkinson's disease (PD) and reduce the variability of rehabilitation methods in clinical practice. A literature search was conducted to...
Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation

Lee S, Ju W, Tin TD, Kim J, Lee JS, Park CH, Kwak SH

Background: BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced...
A Clue to Discovering Unstable Hemoglobin Variants via Abnormal WBC Differential Scattergrams Using the Sysmex Automated Hematology Analyzer

Park S, Jeong TD, Hong KS, Huh J

Incidentally, hemoglobin (Hb) variants can be detected using HbA1c tests in clinical laboratories. We found 38 patients with Hb variants after reviewing a total of 29,398 HbA1c test results from...
Effects of Pre-analytical Variables on Cell-free DNA Extraction for Liquid Biopsy

Jeong TD, Kim MH, Park S, Chung HS, Lee JW, Chang JH, Huh J

BACKGROUND: Extraction of cell-free DNA (cfDNA) is a key step for determining the quality of cfDNA-related molecular diagnostics. We evaluated the effect of sample containers and sample storage conditions on...
Accuracy-Based Proficiency Testing of Creatinine Measurement: 7 Years' Experience in Korea

Jeong TD, Lee HA, Lee K, Yun YM

BACKGROUND: Standardization of creatinine assay is consistently performed and much effort has been put into improving the accuracy of the results. We aimed to analyze the results of accuracy-based proficiency...
Estimated Glomerular Filtration Rates Show Minor but Significant Differences Between the Single and Subgroup Creatinine-Based Chronic Kidney Disease Epidemiology Collaboration Equations

Park S, Jeong TD

The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation can be calculated according to race, sex, and creatinine concentration (subgroup equation) or in the form expressed by one equation (single...
Current Status of Estimated Glomerular Filtration Rate Reporting in Korea

Kim SK, Jeong TD, Park S, Lee YW, Min WK

BACKGROUND: We aimed to investigate the current status of estimated glomerular filtration rate (eGFR) reporting in clinical laboratories for the first time in Korea. METHODS: The eGFR proficiency testing data obtained...
Evaluation of the 1B Equation to Estimate Glomerular Filtration Rate in Pediatric Patients with Cancer

Jeong TD, Kim J, Lee W, Chun S, Hong KS, Min WK

The 1B equation is recommended for calculating the glomerular filtration rate (GFR) in children. Since few reports have evaluated the performance of the 1B equation, we investigated the performance of...
Plasma Neutrophil Gelatinase-Associated Lipocalin as a Marker of Tubular Damage in Diabetic Nephropathy

Kim SY, Jeong TD, Lee W, Chun S, Sunwoo S, Kim SB, Min WK

BACKGROUND: An increase in neutrophil gelatinase-associated lipocalin (NGAL) indicates tubular injury. Diabetic nephropathy causes typical changes in the kidney, characterized by glomerulosclerosis and eventual tubular damage. We validated the usefulness...
Performance Evaluation of the Point-of-Care Cardiac Troponin T Assay

Kim YH, Jeong TD, Hong KS

BACKGROUND: The point-of-care (POC) troponin T assay has been used in various clinical settings. Recently, a POC troponin T assay with an extended measurable range (40 ng/L-2,000 ng/L) was introduced....
Intactness of Medical Nonsterile Gloves on Use of Alcohol Disinfectants

Chang J, Jeong TD, Lee S, Kim Y, Lee J, Lee HK, Kwon HJ

No abstract available.
Accuracy Assessment of Five Equations Used for Estimating the Glomerular Filtration Rate in Korean Adults

Jeong TD, Cho EJ, Lee W, Chun S, Hong KS, Min WK

BACKGROUND: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration...
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy

Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury and has distinctive neuropathological features that differentiate this disease from other neurodegenerative diseases. Intraneuronal...
Prognostic Implications of Elevated Cardiac Troponin T in Patients with Acute Ischemic Stroke

Jung CL, Jeong TD, Hong KS

BACKGROUND: Elevated cardiac troponin T (cTnT) levels have been reported in patients with acute ischemic stroke, however, the prognostic relevance is not well established. We evaluated the association between cTnT...
Prognostic relevance of the Ki-67 proliferation index in patients with mantle cell lymphoma

Jeong TD, Chi HS, Kim MS, Jang S, Park CJ, Huh JR

BACKGROUND: A high Ki-67 proliferation index (PI) in neoplastic cells is associated with poor survival in mantle cell lymphoma (MCL). We aimed to determine the cut-off values for the Ki-67...
Role of Soluble ST2 as a Prognostic Marker in Patients with Acute Heart Failure and Renal Insufficiency

Kim MS, Jeong TD, Han SB, Min WK, Kim JJ

This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in...
Performance Evaluation of the Elecsys Neuron-Specific Enolase Assay

Kim SK, Jeong TD, Lee W, Chun S, Min WK

BACKGROUND: Neuron-specific enolase (NSE) is an enzyme specifically found in neurons and neuroendocrine tissue. It is a common marker for small cell lung cancer diagnosis and is also useful as...
Comparison of Red Blood Cell Hemolysis Using Plasma and Serum Separation Tubes for Outpatient Specimens

Ko DH, Won D, Jeong TD, Lee W, Chun S, Min WK

BACKGROUND: To rapidly obtain outpatient results, we use plasma separation tubes (PST) for chemistry analysis. If lactate dehydrogenase measurement is required, serum separation tubes (SST) are used. There has been...
Annual Report on the External Quality Assessment Scheme for Therapeutic Drug Monitoring and Testing for Drugs of Abuse in Korea (2014)

Ko DH, Jeong TD, Gu GG, Chun S, Kim JH, Therapeutic Drug Monitoring Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratories

As the Therapeutic Drug Monitoring Subcommittee (TDMS) of the Korean Association of Quality Assurance for Clinical Laboratories (KAQACL), we organised two trials as an external quality assessment of therapeutic drug...

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