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Clinical Experience with Use of Remdesivir in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2: a Case Series

Lee C, Ahn MY, Byeon K, Choi JP, Hahm C, Kim H, Kim S, Kim TH, Oh J, Oh DH

  • Infect Chemother.
  • 2020 Sep;52(3):369-380.
  • doi: 10.3947/ic.2020.52.3.369
Background: A novel antiviral agent, remdesivir (RDV), is a promising candidate treatment for coronavirus disease 2019 (COVID-19) in the absence of any proven therapy. Materials and Methods: This retrospective case series...
Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

Lee B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):27-37.
  • doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but...
Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2018 Sep;22(5):525-538.
  • doi: 10.4196/kjpp.2018.22.5.525
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported...
Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2018 Mar;22(2):183-192.
  • doi: 10.4196/kjpp.2018.22.2.183
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear...
The Pallidal Index in Patients with Acute-on-Chronic Liver Disease: Is It a Predictor of Severe Hepatic Encephalopathy?

Lee DH, Lee HJ, Hahm MH

  • Investig Magn Reson Imaging.
  • 2017 Sep;21(3):125-130.
  • doi: 10.13104/imri.2017.21.3.125
PURPOSE: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which...
Bile Flow Phantom Model and Animal Bile Duct Dilation Model for Evaluating Biliary Plastic Stents with Advanced Hydrophilic Coating

Kwon CI, Kim G, Jeong S, Lee WS, Lee DH, Ko KH, Hong SP, Hahm KB

  • Gut Liver.
  • 2016 Jul;10(4):632-641.
  • doi: 10.5009/gnl15417
BACKGROUND/AIMS: The efforts to improve biliary plastic stents (PSs) for decreasing biofilm formation and overcome short patency time have been continued. The aim of this study is to evaluate the...
Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):357-366.
  • doi: 10.4196/kjpp.2016.20.4.357
Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of...
Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats

Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2016 May;24(3):328-337.
  • doi: 10.4062/biomolther.2015.152
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these...
Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration

Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2015 Nov;23(6):571-581.
  • doi: 10.4062/biomolther.2015.027
beta-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and...
Erratum to "L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats" [Biomol. Ther. 22 (2014) 213-222]

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2014 Sep;22(5):474-474.
  • doi: 10.4062/biomolther.2014.474
In the article, incorrect images were placed in Fig. 8.
Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2014 Jun;18(3):191-200.
  • doi: 10.4196/kjpp.2014.18.3.191
We investigated the anxiolytic-like activity of alpha-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The...
L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2014 May;22(3):213-222.
Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitary-adrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The...
The Change of Thyroid Stimulating Hormone Values of Healthy Subjects According to Temperature and Aging

Kim SS, Lew DH, Choi JY, Lee EJ, Kim MG, Kim KY, Kim SK, Jung JH, Jung JH, Hahm JR

  • Kosin Med J.
  • 2014 Dec;29(2):125-134.
  • doi: 10.7180/kmj.2014.29.2.125
OBJECTIVES: We conducted a study to investigate the normal range for TSH and within-individual variations of TSH according to temperature and aging. PATIENTS AND METHODS: We enrolled patients who underwent periodic...
Functional Self-Expandable Metal Stents in Biliary Obstruction

Kwon CI, Ko KH, Hahm KB, Kang DH

  • Clin Endosc.
  • 2013 Sep;46(5):515-521.
Biliary stents are widely used not only for palliative treatment of malignant biliary obstruction but also for benign biliary diseases. Each plastic stent or self-expandable metal stent (SEMS) has its...
Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats

Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2013 Sep;21(5):381-390.
The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and inflammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of...
Chronic Administration of Catechin Decreases Depression and Anxiety-Like Behaviors in a Rat Model Using Chronic Corticosterone Injections

Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2013 Jul;21(4):313-322.
Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study...
Association between Symptoms of Irritable Bowel Syndrome and Methane and Hydrogen on Lactulose Breath Test

Lee KN, Lee OY, Koh DH, Sohn W, Lee SP, Jun DW, Lee HL, Yoon BC, Choi HS, Hahm JS

  • J Korean Med Sci.
  • 2013 Jun;28(6):901-907.
  • doi: 10.3346/jkms.2013.28.6.901
Whether hydrogen and methane gas produced during lactulose breath test (LBT) are associated with symptoms of irritable bowel syndrome (IBS) is not determined. We aimed to investigate whether hydrogen and...
Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats

Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2013 Oct;17(5):393-403.
  • doi: 10.4196/kjpp.2013.17.5.393
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated...
Contacts Burns Caused by Electric Pad

Kwon DH, Ko JH, Hur GY, Seo DK, Lee JW, Choi JK, Jang YC, Hahm MC

  • J Korean Burn Soc.
  • 2012 Jun;15(1):9-14.
PURPOSE: The use of the Ondol, which is a traditional Korean floor heating system, has made the electric heating pad popular in Korea. Although the surface temperature of electric pads...
Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats

Lee B, Sur B, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2012 Apr;16(2):79-89.
  • doi: 10.4196/kjpp.2012.16.2.79
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic...

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