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Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report

Kumar R, Hsiang JC, Tan J, Thurairajah PH

No abstract available.
Self-management Experience of Middle-aged and Older Adults With Type 2 Diabetes: A Qualitative Study

Wu FL, Tai HC, Sun JC

PURPOSE: Diabetes mellitus has been either the fourth or fifth leading cause of death among Taiwanese adults during 1995–2015. Older adults with diabetes are at higher risk of developing diabetic...
VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature

Wong YJ, Chew SY, Hsiang JC, Thurairajah PH, Kumar R, Teo EK, Gokhale RS, Noor IB, Tan J

No abstract available.
Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway

Liu CL, Chen MJ, Lin JC, Lin CH, Huang WC, Cheng SP, Chen SN, Chang YC

PURPOSE: Cancer cells develop acquired resistance induced by chemotherapeutic drugs. In this study, we investigated the effects of brief treatment with cytotoxic drugs on the phenotype of breast cancer cells. METHODS:...
The Role of Consolidation Chemoradiotherapy in Locally Advanced Pancreatic Cancer Receiving Chemotherapy: An Updated Systematic Review and Meta-Analysis

Chang JS, Chiu YF, Yu JC, Chen LT, Ch'ang HJ

PURPOSE: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using...
Ossification of the Posterior Longitudinal Ligament in Cervical Spine: Prevalence, Management, and Prognosis

Wu JC, Chen YC, Huang WC

Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine and related neurological complications are not uncommon in East Asian countries. The estimated prevalence of cervical OPLL-related hospitalization is...
Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma

Lin TJ, Karmaus WJ, Chen ML, Hsu JC, Wang IJ

PURPOSE: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase...
The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Liu CY, Huang TT, Chu PY, Huang CT, Lee CH, Wang WL, Lau KY, Tsai WC, Chao TI, Su JC, Chen MH, Shiau CW, Tseng LM, Chen KF

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In...
Status of Laboratory Biosafety and Biosecurity in Veterinary Research Facilities in Nigeria

Odetokun I, Jagun-Jubril AT, Onoja BA, Wungak YS, Raufu IA, Chen JC

BACKGROUND: This study determined current status of laboratory biosafety in Nigerian veterinary research facilities. METHODS: A questionnaire was developed to obtain information from researchers across Nigeria from July 2014 to July...
Efficacy and Safety of Intravenous Urapidil for Older Hypertensive Patients with Acute Heart Failure: A Multicenter Randomized Controlled Trial

Yang W, Zhou YJ, Fu Y, Qin J, Qin S, Chen XM, Guo JC, Wang DZ, Zhan H, Li J, He JY, Hua Q

PURPOSE: Urapidil is putatively effective for patients with hypertension and acute heart failure, although randomized controlled trials thereon are lacking. We investigated the efficacy and safety of intravenous urapidil relative...
Preclinical Study of Cell Therapy for Osteonecrosis of the Femoral Head with Allogenic Peripheral Blood-Derived Mesenchymal Stem Cells

Fu Q, Tang NN, Zhang Q, Liu Y, Peng JC, Fang N, Yu LM, Liu JW, Zhang T

PURPOSE: To explore the value of transplanting peripheral blood-derived mesenchymal stem cells from allogenic rabbits (rPBMSCs) to treat osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: rPBMSCs were separated/cultured from...
A Systemic Review and Experts' Consensus for Long-acting Injectable Antipsychotics in Bipolar Disorder

Chou YH, Chu PC, Wu SW, Lee JC, Lee YH, Sun IW, Chang CL, Huang CL, Liu IC, Tsai CF, Yen YC

Bipolar disorder (BD) is a major psychiatric disorder that is easily misdiagnosed. Patient adherence to a treatment regimen is of utmost importance for successful outcomes in BD. Several trials of...
Accelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum

Cheon SH, Yan BC, Chen BH, Park JH, Ahn JH, Kim IH, Lee JC, Park YS, Kim MJ, Lee YL, Cho JH, Won MH

BACKGROUND: Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little research regarding the effects of HFD-induced obesity...
Regulation of matrix metalloproteinase-9 protein expression by 1alpha,25-(OH)2D3 during osteoclast differentiation

Gu JH, Tong XS, Chen GH, Liu XZ, Bian JC, Yuan Y, Liu ZP

To investigate 1alpha,25-(OH)2D3 regulation of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered...
Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus

Yan BC, Kim IH, Park JH, Ahn JH, Cho JH, Chen BH, Lee JC, Choi JH, Yoo KY, Lee CH, Cho JH, Kim JD, Won MH

  • KMID: 2312107
  • Lab Anim Res.
  • 2013 Sep;29(3):148-155.
In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation,...
Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool

Gwee KA, Ghoshal UC, Gonlachanvit S, Chua AS, Myung SJ, Rajindrajith S, Patcharatrakul T, Choi MG, Wu JC, Chen MH, Gong XR, Lu CL, Chen CL, Pratap N, Abraham P, Hou XH, Ke M, Ricaforte-Campos JD, Syam AF, Abdullah M

  • KMID: 2325787
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):149-160.
Chronic constipation (CC) may impact on quality of life. There is substantial patient dissatisfaction; possible reasons are failure to recognize underlying constipation, inappropriate dietary advice and inadequate treatment. The aim...
Follicular Dendritic Cell Sarcoma of the Omentum: Multidetector Computed Tomography Findings

Chien JC, Lao WT, Chen CL, Chan WP

We report computed tomography (CT) findings for a rare case of follicular dendritic cell sarcoma of the greater omentum from a 47-year-old female patient. The tumor presented ash a palpable...
The Evaluation of Otilonium Bromide Treatment in Asian Patients With Irritable Bowel Syndrome

Chang FY, Lu CL, Luo JC, Chen TS, Chen MJ, Chang HJ

  • KMID: 2325842
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):402-410.
BACKGROUND/AIMS: Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to...
Relationship of Facet Tropism with Degeneration and Stability of Functional Spinal Unit

Kong MH, He W, Tsai YD, Chen NF, Keorochana G, Do DH, Wang JC

PURPOSE: The authors investigated the effect of lumbar facet tropism (FT) on intervertebral disc degeneration (DD), facet joint degeneration (FJD), and segmental translational motion. MATERIALS AND METHODS: Using kinetic MRI...
Impact of Clinical Characteristics of Individual Metabolic Syndrome on the Severity of Insulin Resistance in Chinese Adults

Hsieh CH, Hung YJ, Wu DA, Kuo SW, Lee CH, Sheu WH, Li JC, Yeh KH, Chen CY, Pei D

The impact the metabolic syndrome (MetS) components on the severity of insulin resistance (IR) has not been reported. We enrolled 564 subjects with MetS and they were divided into quartiles...

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