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Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy

Woo CY, Baek JY, Kim AR, Hong CH, Yoon JE, Kim HS, Yoo HJ, Park TS, Kc R, Lee KU, Koh EH

Background: Ceramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also,...
Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study

Moon JS, Suh S, Kim SS, Jin HY, Kim JM, Jang MH, Lee KA, Lee JH, Chung SM, Lyu YS, Kim JH, Kim SY, Jang JE, Kim TN, Kim SW, Jeon E, Cho NH, Kim MK, Kim HS, Nam-Goong IS, Kim ES, Chung JO, Cho DH, Lee CW, Kim YI, Chung DJ, Won KC, Kim IJ, Park TS, Kim DK, Shon H

Background: Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness...
The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells

Chiang CY, Hsu KD, Lin YY, Hsieh CW, Liu JM, Lu TY, Cheng KC

Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent...
The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study

Chung SM, Lee YY, Ha E, Yoon JS, Won KC, Lee HW, Hur J, Hong KS, Jang JG, Jin HJ, Choi EY, Shin KC, Chung JH, Lee KH, Ahn JH, Moon JS

Background: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as...
Retethering : A Neurosurgical Viewpoint

Lee JY, Kim KH, Park K, Wang KC

During the follow-up period after surgery for spinal dysraphism, a certain portion of patients show neurological deterioration and its secondary phenomena, such as motor, sensory or sphincter changes, foot and...
Enlargement of Extraspinal Cysts in Spinal Dysraphism : A Reason for Early Untethering

Kim KH, Wang KC, Lee JY

Some types of spinal dysraphism can be accompanied by extraspinal cysts, including myelomeningocele, myelocystocele, myelocele, meningocele, limited dorsal myeloschisis, lipomyelomeningocele, and terminal myelocystocele. Each disease is classified according to the...
Syringomyelia in the Tethered Spinal Cords

Lee JY, Kim KH, Wang KC

Cases of syringomyelia associated with spinal dysraphism are distinct from those associated with hindbrain herniation or arachnoiditis in terms of the suspected pathogenetic mechanism. The symptoms of terminal syringomyelia are...
Terminal Myelocystocele : Pathoembryogenesis and Clinical Features

Lee JY, Kim KH, Wang KC

There has been confusion in the classification of terminal myelocystocele (TMCC) due to its diverse morphology and vague pathoembryogenesis. TMCC could be summarized as having the essential features of an...
Secondary Neurulation Defects-1 : Retained Medullary Cord

Kim KH, Lee JY, Wang KC

Retained medullary cord (RMC) is a relatively recent term. Pang et al. newly defined the RMC as a late arrest of secondary neurulation leaving a non-functional vestigial portion at the...
Spinal Dysraphism in the Last Two Decades : What I Have Seen during the Era of Dynamic Advancement

Wang KC

Compared to any other decade, the last two decades have been the most dynamic period in terms of advances in the knowledge on spinal dysraphism. Among the several factors of...
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?

Park S, Lee HY, Cho EJ, Sung KC, Kim J, Kim DH, Ihm SH, Kim Ki, Sohn IS, Chung WJ, Kim HC, Ryu SK, Pyun WB, Shin J, Korean Society of Hypertension

Antihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of...
The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond

Moon JS, Karunakaran U, Suma E, Chung SM, Won KC

Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential...
The Outbreak of COVID-19 and Diabetes in Korea:“We Will Find a Way as We Have Always Done”

Won KC, Yoon KH

ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB

Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene...
Changes in the Quality of Life in Patients with Type 2 Diabetes Mellitus According to Physician and Patient Behaviors

Kim YJ, Jeong IK, Kim SG, Cho DH, Kim CH, Kim CS, Lee WY, Won KC, Cha JH, Lee J, Kim DM

BACKGROUND: Diabetes mellitus (DM) is the most common chronic metabolic disorder with an increasing prevalence worldwide. According to a previous study, physicians' treatment patterns or patients' behaviors change when they...
Corrigendum: The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate

Chae JB, Choi HR, Shin JW, Na JI, Huh CH, Park KC

Clinical Usefulness of ¹⁸F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial

Lee I, Na HR, Byun BH, Lim I, Kim BI, Choi CW, Ko IO, Lee KC, Kim KM, Park SY, Kim YK, Lee JY, Bu SH, Kim JH, Kil HS, Park C, Chi DY, Ha JH, Lim SM

BACKGROUND AND PURPOSE: The aim of this study was to determine the diagnostic performance and safety of a new ¹⁸F-labeled amyloid tracer, ¹⁸F-FC119S. METHODS: This study prospectively recruited 105 participants, comprising...
Epidemiology of C5 Palsy after Cervical Spine Surgery: a 21-Center Study

Oh JK, Hong JT, Kang DH, Kim SW, Kim SW, Kim YJ, Chung CK, Shin JJ, Yi S, Lee JK, Lee JH, Lee CH, Lee HJ, Chun HJ, Cho DC, Cho YE, Jin YJ, Choi KC, Han IH, Hyun SJ, Hur JW, Kim KJ

OBJECTIVE: C5 palsy is a severe complication after cervical spine surgery, the pathophysiology of which remains unclear. This multicenter study investigated the incidence of C5 palsy following cervical spine surgery...
Characteristics and Treatment Outcome of Intracranial Aneurysms in Children and Adolescents

Nam SM, Jang D, Wang KC, Kim SK, Phi JH, Lee JY, Cho WS, Kim JE, Kang HS

OBJECTIVE: Intracranial aneurysms are not common in young age patients. We sought to find the characteristics of the intracranial aneurysms in patients under 20 years of age. METHODS: We reviewed 23...
Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model

Lee H, Yeom A, Kim KC, Hong YM

BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased...

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