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Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death

Jiang YJ, Cui S, Luo K, Ding J, Nan QY, Piao SG, Xuan MY, Zheng HL, Jin YJ, Jin JZ, Lee JP, Chung BH, Choi BS, Yang CW, Li C

Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a...
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L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Zhao HY, Li HY, Jin J, Jin JZ, Zhang LY, Xuan MY, Jin XM, Jiang YJ, Zheng HL, Jin YS, Jin YJ, Choi BS, Yang CW, Piao SG, Li C

Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on...
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Shen-Kang protects against tacrolimus-induced renal injury

Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C

BACKGROUND/AIMS: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a...
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