- Drug Discovery Platform Using Organoids
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Maeng JE, Kim SC, Song MH, Jeong N, Ku JL
- KMID: 2536425
- J Dig Cancer Res.
- 2022 Dec;10(2):82-91.
- doi: 10.52927/jdcr.2022.10.2.82
Gastrointestinal cancer accounts for one-third of the overall cancer occurrence worldwide. Pancreatic ductal adenocarcinoma (PDAC) is a type of gastrointestinal cancer that is known to be one of the most fatal... -
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- Novel Drug Screening Platform: Tumor Organoid
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Maeng JE, Seo HY, Kim SC, Ku JL
- KMID: 2522024
- Korean J Pancreas Biliary Tract.
- 2021 Oct;26(4):233-240.
- doi: 10.15279/kpba.2021.26.4.233
Pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal cancers among all cancer types, with a relative 5-year survival rate of less than 8%. Currently, surgery... -
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- Biology of SNU Cell Lines
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Ku JL, Park JG
- KMID: 1743349
- Cancer Res Treat.
- 2005 Feb;37(1):1-19.
SNU (Seoul National University) cell lines have been established from Korean cancer patients since 1982. Of these 109 cell lines have been characterized and reported, i.e., 17 colorectal carcinoma, 12... -
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- Germline Mutation of Rb1 Gene in Korean Retinoblastoma Patients
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Ku JL, Yu YS, Park JG
- KMID: 2175466
- J Korean Cancer Assoc.
- 1997 Apr;29(2):291-298.
PURPOSE: Retinoblastoma is an intraocular tumor occurring almost exclusively in young children. Germline mutations in the Rb1 gene confer hereditary predisposition to retinoblastoma. To identify germline mutations in the Rb1... -
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- Effects of granulocyte-colony stimulating factor and the expression of its receptor on various malignant cells
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Moon HW, Kim TY, Oh BR, Hwang SM, Kwon J, Ku JL, Lee DS
- KMID: 2251957
- Korean J Hematol.
- 2012 Sep;47(3):219-224.
- doi: 10.5045/kjh.2012.47.3.219
BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is extensively used to improve neutrophil count during anti-cancer chemotherapy. We investigated the effects of G-CSF on several leukemic cell lines and screened for the... -
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- Comparison of oncologic outcomes between patients with Lynch syndrome and sporadic microsatellite instability-high colorectal cancer
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Son IT, Kim DW, Kim MH, Shin YK, Ku JL, Oh HK, Kang SB, Jeong SYJ, Park KJ
- KMID: 2518329
- Ann Surg Treat Res.
- 2021 Jul;101(1):13-19.
- doi: 10.4174/astr.2021.101.1.13
Purpose: Long-term oncologic differences in outcome between groups of patients with Lynch syndrome (LS) colorectal cancer (CRC) and sporadic CRC with microsatellite instability-high (MSI-H) are the focus of investigation in... -
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- The Effect of Gastrin and Cholecystokinin on the Growth of Pancreato-biliary Cancer Cell Lines
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Jang JY, Kim SW, Yoon YS, Ku JL, Park YH, Park JG
- KMID: 2004562
- J Korean Surg Soc.
- 2003 May;64(5):408-417.
PURPOSE: Gastrin and cholecystokinin (CCK) have been reported to play a role in the development and growth stimulation of gastrointestinal cancers including pancreatic cancer. METHODS: We investigated the effects of... -
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- Acquired Resistance Mechanism of EGFR Kinase Domain Duplication to EGFR TKIs in Non–Small Cell Lung Cancer
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Lee C, Kim M, Kim DW, Kim TM, Kim S, Im SW, Jeon YK, Keam B, Ku JL, Heo DS
- KMID: 2524595
- Cancer Res Treat.
- 2022 Jan;54(1):140-149.
- doi: 10.4143/crt.2021.385
Purpose Epidermal growth factor receptor kinase domain duplication (EGFR-KDD) is a rare and poorly understood oncogenic mutation in non–small cell lung cancer (NSCLC). We aimed to investigate the acquired resistance... -
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- Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades
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Son IT, Kim DW, Jeong SY, Shin YK, Ihn MH, Oh HK, Kang SB, Park KJ, Oh JH, Ku JL, Park JG
- KMID: 2454338
- Cancer Res Treat.
- 2016 Apr;48(2):605-611.
- doi: 10.4143/crt.2015.092
PURPOSE: The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study... -
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- Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies
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Lee JH, Kim H, Lee SH, Ku JL, Chun JW, Seo HY, Kim SC, Paik WH, Ryu JK, Lee SK, Lowy AM, Kim YT
- KMID: 2531245
- Gut Liver.
- 2022 Jul;16(4):625-636.
- doi: 10.5009/gnl210166
Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens. Given that most patients present with locally advanced and/or metastatic disease,... -
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- Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans
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Lee SY, Kim DW, Shin YK, Ihn MH, Lee SM, Oh HK, Ku JL, Jeong SY, Lee JB, Ahn S, Won S, Kang SB
- KMID: 2454345
- Cancer Res Treat.
- 2016 Apr;48(2):668-675.
- doi: 10.4143/crt.2014.288
PURPOSE: Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on... -
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