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Translation: Roadmap for Harmonization of Clinical Laboratory Measurement Procedures

Miller WG, Myers GL, Gantzer ML, Kahn SE, Schonbrunner ER, Thienpont , Bunk DM, Christenson RH, Eckfeldt J, Lo SF, Nubling CM, Sturgeon C

Results between different clinical laboratory measurement procedures (CLMP) should be equivalent, within clinically meaningful limits, to enable optimal use of clinical guidelines for disease diagnosis and patient management. When laboratory...
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Apolipoprotein B Levels Predict Future Development of Hypertension Independent of Visceral Adiposity and Insulin Sensitivity

Han SJ, Fujimoto WY, Kahn SE, Leonetti DL, Boyko EJ

Background: High plasma apolipoprotein B (apoB) levels have been shown to be associated with hypertension, central obesity, and insulin resistance in cross-sectional research. However, it is unclear whether apoB levels...
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Predictors of Incident Type 2 Diabetes Mellitus in Japanese Americans with Normal Fasting Glucose Level

Hwang YC, Fujimoto W, Kahn SE, Leonetti D, Boyko EJ

BACKGROUND: Little is known about the natural course of normal fasting glucose (NFG) in Asians and the risk factors for future diabetes. METHODS: A total of 370 Japanese Americans (163 men,...
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Intra-Abdominal Fat and High Density Lipoprotein Cholesterol Are Associated in a Non-Linear Pattern in Japanese-Americans

Song SO, Hwang YC, Kahn SE, Leonetti DL, Fujimoto WY, Boyko EJ

Background: We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots. Methods: We examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal...
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Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat

Song SO, Hwang YC, Ryu HU, Kahn SE, Leonetti DL, Fujimoto WY, Boyko EJ

Background: Both intra-abdominal fat (IAF) and high-density lipoprotein cholesterol (HDL-C) are known to be associated with cardiometabolic health. We evaluated whether the accumulation of computed tomography (CT)-measured IAF over 5...
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Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans

Han SJ, Boyko EJ, Kim SK, Fujimoto W, Kahn SE, Leonetti D

BACKGROUND: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition,...
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Higher High Density Lipoprotein 2 (HDL2) to Total HDL Cholesterol Ratio Is Associated with a Lower Risk for Incident Hypertension

Hwang YC, Fujimoto W, Kahn SE, Leonetti D, Boyko EJ

BACKGROUND: Recent studies have suggested that high density lipoprotein (HDL) cholesterol is inversely associated with the development of hypertension. We aimed to determine the association between different HDL cholesterol subclasses...
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