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Fucoidan Induces Apoptosis in A2058 Cells through ROS-exposed Activation of MAPKs Signaling Pathway

Ryu YS, Hyun JW, Chung HS

Fucoidan, a natural component of brown seaweed, has various biological activities such as anticancer activity, anti-oxidant, and anti-inflammatory against various cancer cells. However, the fucoidan has been implicated in melanoma...
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Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells

Ryu YS, Shin S, An HG, Kwon TU, Baek HS, Kwon YJ, Chun YJ

Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl,...
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The Introduction of Pavlovian Theory and the Change of the Medical System in China in the 1950s: Focusing on the Construction of the Protective Medical System

YU YS

In the 1930s, Stalin established Pavlovian theory as a socialist medical theory, criticized bourgeois science and ideology, and consolidated his dictatorship. Stalin used Pavlov's theory to emphasize the interaction between...
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Reliability and Validity of the Korean version of the Pain in Older Adults Knowledge Survey (K-POAKS) among Nurses Who Have Worked in Long-term Care Hospitals

Ryu YS, Park JS

Purpose: The purpose of this study was to verify the validity and reliability of the Korean version of the Pain in Older Adults Knowledge Survey (K-POAKS) to assess knowledge of...
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Pharmacotherapy of Diabetes Focused on Stroke

Lyu YS, Kim JH, Kim SY

Cardiovascular disease, including stroke, is one of the major causes of death in diabetes. Numerous studies have long suggested reducing macrovascular complication such as ischemic vascular disease through intensive glycemic...
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Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5

Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, Hyun JW

Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis...
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Development and Effect of Evidence-based Nursing Practice Guidelines for Pain Management in Patients with Dementia

Ryu YS, Park JS

PURPOSE: This study aimed to develop evidence-based nursing practice guidelines for pain management in patients with dementia and to verify their effects. METHODS: Guidelines were developed according to the Clinical Practice...
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Factors Associated with the Prognosis after Operation in Children with Recurrent Intermittent Exotropia

Kim JA, Yu YS, Kim SJ

BACKGROUND: To describe factors affecting the prognosis after operation for recurrent intermittent exotropia (X[T]) in children. METHODS: Clinical records of 50 patients who underwent operation for recurrent X(T) by a single...
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7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress

Cho SJ, Kang KA, Piao MJ, Ryu YS, Fernando P, Zhen AX, Hyun YJ, Ahn MJ, Kang HK, Hyun JW

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent...
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Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW

The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated...
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Long-term Lens Complications Following Removal of Persistent Pupillary Membrane

Lee HJ, Kim JH, Kim SJ, Yu YS

PURPOSE: We evaluated the long-term surgical outcome and lens complications in children with persistent pupillary membrane following removal using vitreous scissors. METHODS: Patients diagnosed with persistent pupillary membrane who received surgical...
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Effects on Periocular Tissues after Proton Beam Radiation Therapy for Intraocular Tumors

Choi YJ, Kim TW, Kim S, Choung H, Lee MJ, Kim N, Khwarg SI, Yu YS

BACKGROUND: To present our experience on orbital and periorbital tissue changes after proton beam radiation therapy (PBRT) in patients with intraocular tumors, apart from treatment outcomes and disease control. METHODS: Medical...
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Factors Influencing Posttraumatic Growth in Cancer Survivors

Park JS, Kim YJ, Ryu YS, Park MH

PURPOSE: The purpose of this study was to identify the level of post-traumatic growth (PTG) and the factors affecting the PTG of cancer survivors. METHODS: Data were collected from 147 cancer...
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Relationship between Pericytes and Endothelial Cells in Retinal Neovascularization: A Histological and Immunofluorescent Study of Retinal Angiogenesis

Choi SH, Chung M, Park SW, Jeon NL, Kim JH, Yu YS

PURPOSE: To evaluate the relationship between pericytes and endothelial cells in retinal neovascularization through histological and immunofluorescent studies. METHODS: C57BL/6J mice were exposed to hyperoxia from postnatal day (P) 7 to...
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Fluorescein Angiographic Abnormalities in the Contralateral Eye with Normal Fundus in Children with Unilateral Coats' Disease

Jung EH, Kim JH, Kim SJ, Yu YS

PURPOSE: We report the detection of peripheral retinal vascular abnormalities in the fellow eye with normal fundus in children with unilateral Coats' disease. METHODS: The clinical records of patients diagnosed with...
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Validation of the OncoHepa test, a multigene expression profile test, and the tumor marker-volume score to predict postresection outcome in small solitary hepatocellular carcinomas

Ha SM, Hwang S, Park JY, Lee YJ, Kim KH, Song GW, Jung DH, Yu YS, Kim J, Lee KJ, Tak E, Park YH, Lee SG

PURPOSE: OncoHepa test is a multigene expression profile test developed for assessment of hepatocellular carcinoma (HCC) prognosis. Multiplication of α-FP, des-γ-carboxy prothrombin (DCP) and tumor volume (TV) gives the α-FP-DCP-volume...
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Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes

Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW

Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved...
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Ophthalmologic Features of Lennox-Gastaut Syndrome

Kim BH, Yu YS, Kim SJ

PURPOSE: To describe the characteristics and frequency of ophthalmologic findings in patients with Lennox-Gastaut syndrome (LGS). METHODS: The medical records of patients diagnosed with LGS at Seoul National University Children's Hospital...
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Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells

Yao CW, Kang KA, Piao MJ, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Na SY, Jeong SU, Boo SJ, Hyun JW

We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and...
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Evaluation on Criterion Validity of Enterprise Health Promotion Index

Lee J, Ryoo JJ, Yu YS, Lee B

PURPOSE: This study was conducted to evaluate the validity of the ‘ Enterprise Health Promotion Index’, a tool for assessing health promotion activities of worksite developed by the Ministry of...
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