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Effectiveness of nivolumab versus regorafenib in hepatocellular carcinoma patients who failed sorafenib treatment

Lee CH, Lee YB, Kim MA, Jang H, Oh H, Kim SW, Cho EJ, Lee KH, Lee JH, Yu SJ, Yoon JH, Kim TY, Kim YJ

Background/Aims: Several treatment options are currently available for patients with hepatocellular carcinoma (HCC) failing previous sorafenib treatment. We aimed to compare the effectiveness of regorafenib and nivolumab in these patients. Methods:...
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Proposal of a New Risk Score for Patients Treated with Transarterial Chemoembolization due to Recurrent Hepatocellular Carcinoma after Curative Resection: A Multicenter Study

Jeon MY, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Lee JH, Yu SJ, Kim YJ, Yoon JH, Cho EJ, Kim SU

Background/Aims: Prognostic models are lacking for patients with recurrent hepatocellular carcinoma (HCC) following surgical resection. This study devised and validated a new hepatoma arterial-embolization prognostic (HAP) score optimized for use...
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Appraisal of a Model to Estimate Survival in Ambulatory Patients with Hepatocellular Carcinoma Classified as Barcelona Clinic Liver Cancer Stage B

Yoo JJ, Yu SJ, Lee B, Cho EJ, Lee JH, Kim SG, Kim YJ, Kim YS, Yoon JH

Background/Aims: Patients with an intermediate stage of hepatocellular carcinoma (HCC) represent a highly heterogeneous population; therefore, many models have been proposed to predict the survival of these patients. The aim...
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Deciphering and Reversing Immunosuppressive Cells in the Treatment of Hepatocellular Carcinoma

Yu SJ, Greten TF

Use of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) has been partially successful. However, most HCC patients do not respond to immunotherapy. HCC has been shown to induce several...
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Comparison of changes in the buccal keratinized mucosa between the minimally-invasive crestal incision and apically-positioned full-thickness flap methods for stage-two implant surgery

Yang KI, Yang JM, Lee KW, Lee WP, Kim BO, Yu SJ

Stage-two implant surgery, which exposes the implant platform to connect the healing abutment, affects the width of the peri-implant keratinized mucosa thereby affecting the long-term prognosis of the implant. The...
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Inhibitory effect of pomegranate extract powder on periodontitis in rat

Kim JH, Lee KH, Sung SJ, Kang KM, Lim YK, Kook JK, Lee WP, Kim BO, Yu SJ

This study aimed to investigate the effect of pomegranate extract (PE) on the progression of periodontal disease in an experimental rat model of periodontitis. Periodontitis was induced in rats by...
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Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B

Cho YY, Chang Y, Nam JY, Cho Hk, Cho EJ, Lee JH, Yu SJ, Yoon JH, Kim YJ

Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF). We sought to determine the long-term...
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Percutaneous Trans-splenic Obliteration for Duodenal Variceal bleeding: A Case Report

Kim HW, Yoon JS, Yu SJ, Kim TH, Seol JH, Kim D, Jung JY, Jeong PH, Kwon H, Lee HS, Lee SH, Choi JS, Park SJ, Jee SR, Lee YJ, Seol SY

Duodenal varices are a serious complication of portal hypertension. Bleeding from duodenal varices is rare, but when bleeding does occur, it is massive and can be fatal. Unfortunately, the optimal...
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Two-Dimensional-Shear Wave Elastography with a Propagation Map: Prospective Evaluation of Liver Fibrosis Using Histopathology as the Reference Standard

Lee DH, Lee ES, Lee JY, Bae JS, Kim H, Lee KB, Yu SJ, Cho EJ, Lee JH, Cho YY, Han JK, Choi BI

Objective: The aim of this study was to prospectively evaluate whether liver stiffness (LS) assessments, obtained by twodimensional (2D)-shear wave elastography (SWE) with a propagation map, can evaluate liver fibrosis...
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Child-Pugh B or C Cirrhosis Increases the Risk for Bleeding Following Colonoscopic Polypectomy

Soh H, Chun Jy, Hong SW, Park Sn, Lee YB, Lee HJ, Cho EJ, Lee JH, Yu SJ, Im JP, Kim YJ, Kim JS, Yoon JH

Background/Aims: The risk for colonoscopic postpolypec-tomy bleeding (PPB) in patients with chronic liver disease (CLD) remains unclear. We determined the incidence and risk factors for colonoscopic PPB in patients with...
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Hepatocellular Carcinoma with Segmental Portal Vein Invasion Exhibiting a Complete Response after Transarterial Radioembolization

Yoon JS, Yu SJ, Lee YB, Cho EJ, Lee JH, Kim YJ, Yoon JH

The treatment options available for patients with hepatocellular carcinoma (HCC) with portal vein invasion (PVI) include sorafenib, transarterial radioembolization (TARE), radiation therapy (RT), transarterial chemoembolization with RT, and proton beam...
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Tenofovir and Entecavir Have Similar Renal Adverse Events on Hepatocellular Carcinoma Patients Treated with Transarterial Chemoembolization

Cho YY, Choi YH, Yu SJ, Cho EJ, Lee JH, Kim YJ, Yoon JH

BACKGROUND/AIMS: Tenofovir disoproxil fumarate (TDF) is potentially nephrotoxic in chronic hepatitis B patients. Hepatocellular carcinoma (HCC) patients treated using transarterial chemoembolization (TACE) are at an increased risk of renal injury....
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Computed tomographic analysis of maxillary sinus anatomy relevant to sinus lift procedures in edentulous ridges in Taiwanese patients

Yu SJ, Lee YH, Lin CP, Wu AY

PURPOSE: To analyze the maxillary sinus anatomy over edentulous ridges in the bilateral posterior maxillary area in Taiwanese patients using cone-beam computed tomography (CBCT). METHODS: In total, 101 anatomical sites from...
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Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats

Sung SJ, Kang KM, Lee KH, Yoo SY, Kook JK, Lee DS, Yu SJ

The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar...
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The correlation of heart rate between natural sleep and dexmedetomidine sedation

Kang D, Lim C, Shim DJ, Kim H, Kim JW, Chung HJ, Shin Y, Kim JD, Ryu SJ

BACKGROUND: Sedation by dexmedetomidine, like natural sleep, often causes bradycardia. We explored the nature of heart rate (HR) changes as they occur during natural sleep versus those occurring during dexmedetomidine...
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Bone and tissue reaction of porous nickel-titanium alloy implant for dental implants in rabbits

Min GH, Lee KH, Sung SJ, Lee WP, Yu SJ, Kim BO

Porous nickel–titanium (Ni-Ti) alloy implants have been previously introduced, and many studies have been performed. Porous Ni-Ti alloys have excellent properties for use in the dental field. Thus, the use...
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Guided bone regeneration in peri-implant defects using a 1:1 mixture of cancellous and cortical freeze-dried bone allograft: A randomized controlled trial

Lee WP, Park DY, Lee KW, Yang KI, Kim BO, Yu SJ

The results of guided bone regeneration (GBR) in peri-implant defects using anorganic bovine bone (ABB) were compared with those using a 1:1 mixture of cancellous and cortical freeze-dried bone allograft...
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Effect of the lateral tilt position on femoral vein cross-sectional area in anesthetized adults

An TH, Shin YS, Kim JW, Park TW, Shim DJ, Kim DS, Ryu SJ, Kim JD

BACKGROUND: A lateral tilt position can affect the size of the femoral vein (FV) due to increased venous blood volume in the dependent side of the body. METHODS: Forty-two patients, aged...
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Assessment of the Surveillance Interval at 1 Year after Curative Treatment in Hepatocellular Carcinoma: Risk Stratification

Lee M, Chang Y, Oh S, Cho YY, Jung DE, Kim HH, Nam JY, Cho H, Cho EJ, Lee JH, Yu SJ, Yi NJ, Lee KW, Lee DH, Lee JM, Yoon JH, Suh KS, Kim YJ

BACKGROUND/AIMS: Guidelines recommend surveillance for hepatocellular carcinoma (HCC) recurrence at 3-month intervals during the first year after curative treatment and 6-month intervals thereafter in all patients. This strategy does not...
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Effects of platelet-rich plasma on tooth replantation in dogs: a histologic and histomorphometric analysis

Yang JM, Yang KI, Lee KH, Choi SH, Kim BO, Park JC, Yu SJ

PURPOSE: The purpose of this study was to evaluate the effects of platelet-rich plasma (PRP) on periodontal healing of replanted root surfaces in dogs histologically and histomorphometrically. METHODS: A total of...
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