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Beta-carotene prevents the spermatogenic disorders induced by exogenous scrotal hyperthermia through modulations of oxidative stress, apoptosis, and androgen biosynthesis in mice

Yon JM, Kim JS, Lin C, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Nam SY

We investigated whether β-carotene (β-CA) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice...
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Long-circulating and target-specific distributions of cyanine 5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days after a single administration

Yun TS, Lin C, Yon JM, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Lee BJ, Yun YW, Nam SY

Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320–400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet...
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Comparative in vivo biodistributions of nanoparticles and polymers of ¹⁷⁷lutetium-labeled hyaluronic acids in mice during 28 days

Lin C, Jeong JY, Yon JM, Park SG, Gwon LW, Lee JG, Baek IJ, Nahm SS, Lee BJ, Yun YW, Nam SY

Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350–400 nm) and larger HA polymers...
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Temporal and subcellular distributions of Cy5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days as a drug carrier

Lin C, Kim SB, Yon JM, Park SG, Gwon LW, Lee JG, Baek IJ, Lee BJ, Yun YW, Nam SY

Temporal and subcellular distributions of hyaluronic acid (HA) as a degradable nanoparticle (NP) in animals were investigated to determine if HA-NP could be utilized as an appropriate drug delivery system....
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Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet

Cha Y, Jang JY, Ban YH, Guo H, Shin K, Kim TS, Lee SP, Choi J, An ES, Seo DW, Yon JM, Choi EK, Kim YB

Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol...
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Hair growth promoting effects of emodin in telogenic C57BL/6 mice

Yon JM, Park SG, Lin C, Gwon LW, Lee JG, Baek IJ, Lee BJ, Yun YW, Nam SY

Emodin is an anthraquinone derivative from the roots of Rheum officinale Baill that possesses a variety of biological activities, including inhibition of 5α-reductase and prostaglandin D2. In this study, we...
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Comparison of teratogenecity induced by nano- and micro-sized particles of zinc oxide in cultured mouse embryos

Jung AY, Jung KY, Lin C, Yon JM, Lee JG, Lee BJ, Yun YW, Nam SY

The increasing uses of zinc oxide nanoparticles (nZnO) in industrial and personal care products raise possible danger of using nZnO in human. To determine whether ZnO induces size-dependent anomalies during...
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Comparative anatomical characteristics of cardiac valves in animals

Nam CH, Kim HY, Lin C, Yon JM

  • KMID: 2168984
  • J Biomed Res.
  • 2014 Mar;15(1):19-23.
Although various animals have been used as models of cardiac valvular diseases in humans, the structural characteristics of cardiac valves in animals remain unclear. In this study, we investigated cardiac...
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Expression Patterns of Superoxide Dismutase Genes in the Stage-specific Seminiferous Tubules of Mice Excised by a Laser Capture Microdissection

Yon JM, Jung AY, Park JH, Hong MK, Kim JS, Lin C, Kim MR, Baek IJ, Lee BJ, Yun YW, Nam SY

  • KMID: 2312065
  • Lab Anim Res.
  • 2010 Jun;26(2):197-201.
Spermatogenesis is a particularly difficult process to study the unique multiple cellular associations within the seminiferous epithelium. Laser capture microdissection (LCM) is a recently developed technique that enables the isolation...
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Immunohistochemical identification and quantitative analysis of cytoplasmic Cu/Zn superoxide dismutase in mouse organogenesis

Yon JM, Baek IJ, Lee SR, Kim MR, Lee BJ, Yun YW, Nam SY

Cytoplasmic Cu/Zn superoxide dismutase (SOD1) is an antioxidant enzyme that converts superoxide to hydrogen peroxide in cells. Its spatial distribution matches that of superoxide production, allowing it to protect cells...
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Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes

Baek IJ, Yon JM, Lee SR, Jin Y, Kim MR, Ahn B, Hong JT, Choo YK, Lee BJ, Yun YW, Nam SY

Phospholipid hydroperoxide glutathione peroxidase(PHGPx), an antioxidative selenoprotein, is modulated byestrogen in the testis and oviduct. To examine whetherpotential endocrine disrupting chemicals (EDCs) affectthe microenvironment of the testes, the expression patternsof...
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A Comparative Study of Outcomes between Emergency and Elective Surgeries for Colon Cancer

Yoo DH, Yon JM, Lee MS, Shin DJ, Ahn BY, Kim BW

  • KMID: 2199264
  • J Korean Soc Coloproctol.
  • 2006 Apr;22(2):113-117.
PURPOSE: The purpose of this study was to compare the efficacy of curative emergency surgery for complicated colon cancer in terms of tumor recurrence and survival compared with that of...
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Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet

Lee BJ, Kang JK, Jung EY, Yun YW, Baek IJ, Yon JM, Lee YB, Sohn HS, Lee JY, Kim KS, Nam SY

  • KMID: 1099836
  • J Vet Sci.
  • 2004 Sep;5(3):227-234.
Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-old ICR mice...
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