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Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases

Yi YS

Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein...
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Role of inflammasomes in inflammatory autoimmune rheumatic diseases

Yi YS

Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of...
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Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway

Kim Y, Kim HG, Han SY, Jeong D, Yang WS, Kim JI, Kim JH, Yi YS, Cho JY

Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however, its role in macrophage-mediated inflammatory responses is not fully understood. In...
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JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38

Yi YS, Kim MY, Cho JY

Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the...
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Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas

Yi YS, Kim SS, Kim WJ, Bae MJ, Kang JH, Choi BG, Jeon YK, Kim BH, Lee BJ, Wang SG, Kim IJ, Kim YK

BACKGROUND/AIMS: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer. METHODS: All...
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Effect of Voriconazole or Itraconazole on the Plasma Concentrations of Tacrolimus in Lung Transplant Recipients

Jung YJ, Yi YS, Ahn JH, Son ES, Park MS, Lee JI, Chang MJ

OBJECTIVE: This study was performed to compare the changes in the blood concentrations of tacrolimus when either itraconazole or voriconazole is together with tacrolimus to prevent or treat invasive aspergillus...
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Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases

Yi YS

Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensive response,...
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Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes

Kim WJ, Kim SS, Lee HC, Song SH, Bae MJ, Yi YS, Jeon YK, Kim BH, Kim YK, Kim IJ

The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus....
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Effect of working time on the film thickness of dental resin cements

Yi YS, Kim SH, Lee JB, Han JS, Yeo IS, Ha SR, Kim HK

PURPOSE: The aim of this study was to compare the film thicknesses of several resin cements as a function of time after mixing and to examine the effect of working...
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Alcohol-induced Hyperlipidemia Is Ameliorated by Orally Administered DWP208, a Sodium Succinate Form of ZYM201

Cho JY, Choi J, Park JG, Yi YS, Hossen MJ, Kim H, Ro J, Cha BC, Yoo ES, Kim JH, Lee J

DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding...
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Clinicopathologic Characteristics of Papillary Microcarcinoma in the Elderly

Kim WJ, Bae MJ, Yi YS, Jeon YK, Kim SS, Kim BH, Kim IJ

BACKGROUND AND OBJECTIVES: Older patients show more aggressive features in papillary thyroid carcinoma (PTC). However, data about clinicopathologic features of older patients in papillary thyroid microcarcinoma (PTMC) are limited. Presently,...
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Primary Squamous Cell Carcinoma of the Liver Initially Presenting with Pseudoachalasia

Choi MK, Kim GH, Song GA, Nam HS, Yi YS, Ahn KH, Kim S, Kim JY, Park DY

  • KMID: 2284276
  • Gut Liver.
  • 2012 Apr;6(2):275-279.
Pseudoachalasia secondary to primary squamous cell carcinoma (SCC) of the liver is extremely rare and has not been reported until now. Here, we report a unique case of primary SCC...
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A Case of Benign Biliary Stricture as a Complication of Photodynamic Therapy for Biliary Papillomatosis

Choi MK, Kim DU, Kim GH, Song GA, Nam HS, Yi YS, Ahn KH, Eom JS

  • KMID: 2243047
  • Korean J Gastrointest Endosc.
  • 2011 May;42(5):327-333.
Biliary papillomatosis is a rare disease with a high risk of recurrence and malignant transformation. Therapeutic options include partial hepatectomy, Whipple's procedure and liver transplantation. If there is no surgical...
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A Case of Duodenal Perforation Caused by Biliary Plastic Stent Treated with Approximation using Endoclip and Detachable Snare

Nam HS, Kim GH, Kim DU, Choi MK, Yi YS, Hwang JM, Kim S

Endoscopic retrograde biliary drainage (ERBD) is useful for the palliative decompression of biliary obstruction. However, the complications of ERBD include cholangitis, hemorrhage, acute pancreatitis, obstruction of the stent, and duodenal...
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The risk factors for herpes zoster in bortezomib treatment in patients with multiple myeloma

Yi YS, Chung JS, Song MK, Shin HJ, Seol YM, Choi YJ, Cho GJ, Lee GW, Moon JH, Hwang IH, Ahn KH, Lee HS, Shin KH, Hwang JM

BACKGROUND: Bortezomib has significant activity in treating multiple myeloma (MM). The risk of herpes zoster (HZ) has been reported to increase significantly with bortezomib treatment, but the predisposing factors for...
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A Case of Rectal Implantation Cysts at an Anastomosis Site after Laparoscopic Low Anterior Resection for a Rectal Cancer

Lee HS, Song GA, Hwang IH, Yi YS, Shin KH, Choi BK, Kim GH, Park DY

  • KMID: 2143575
  • Korean J Gastrointest Endosc.
  • 2010 Jun;40(6):382-386.
Rectal implantation cysts can be caused by continued growth in the submucosa of traumatically misplaced columnar epithelium during previous surgery. Cases of implantation cyst occurring at the site of anastomosis...
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Anthropological Study on Ancient Human Skull and Teeth Discovered from Urn Coffin of Proto-Three Kingdoms Period in Korea

Kim MJ, Kim YS, Oh CS, Lee SJ, Bok GD, Yi YS, Youn SI, Lee NL, Shin DH

  • KMID: 1462529
  • Korean J Phys Anthropol.
  • 2010 Dec;23(4):169-175.
Increase in agricultural production or steel manufacturing during Proto-Three Kingdoms Period enabled ancient people to establish well-organized ancient kingdoms in Korean peninsula. A pottery in which human skeletons were buried,...
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Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence

Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH

  • KMID: 1115947
  • Exp Mol Med.
  • 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric...
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Development of International Medical Teleconference System Using Advanced Research Network and Digital Video Transport System(DVTS)

Kim YW, Kang CH, Youm SK, Shimizu S, Nakashima , Noshiro H, Yi YS, You BS, Sung DH, Jeong SY, Chung KW, Baik YH, Lee WJ

  • KMID: 2330437
  • J Korean Soc Med Inform.
  • 2004 Dec;10(4):397-406.
OBJECTIVE: The purpose of this study is to develop telesurgical conference system by establishing a gigabit broad-banded network between hospitals in Korea and Japan using Digital Video Transport System(DVTS) on...
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