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The health-related quality-of-life of chronic obstructive pulmonary disease patients and disease-related indirect burdens

Choi HS, Yang DW, Rhee CK, Yoon HK, Lee JH, Lim SY, Kim YI, Yoo KH, Hwang YI, Lee SH, Park YB

Background/Aims: Many chronic obstructive pulmonary disease (COPD) patients have physical limitations. We investigated EuroQol five-dimensions five-level (EQ-5D-5L) of COPD patients to assess quality of life, and assessed indirect burden including time...
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Direct reprogramming of fibroblasts into diverse lineage cells by DNA demethylation followed by differentiating cultures

Yang DW, Moon J, Ko HM, Shin YK, Fukumoto S, Kim SH, Kim MS

Direct reprogramming, also known as a trans-differentiation, is a technique to allow mature cells to be converted into other types of cells without inducing a pluripotent stage. It has been...
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Coping with Dementia in the Middle of the COVID-19 Pandemic

Ryoo Ny, Pyun JM, Baek MJ, Suh Jw, Kang MJ, Wang MJ, Youn YC, Yang DW, Kim SY, Park YH, Kim SY

Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on...
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Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition

Kim A, Kim S, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW

BACKGROUND AND PURPOSE: We aimed to determine the reliability and validity of a short form of the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as a screening tool for cognitive dysfunction. METHODS: This...
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Coexistence of Cerebral Microbleeds and Amyloid Pathology in Patients with Cognitive Complaints

Lim EY, Ryu SY, Shim YS, Yang DW, Cho AH

BACKGROUND AND PURPOSE: We investigated the prevalence of amyloid positivity and cerebral microbleeds (CMBs) in subjects with cognitive complaints with the aim of identifying differences in clinical parameters and cognitive...
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A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea

Kim A, Kim S, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW

BACKGROUND: Korea has a periodic general health check-up program that uses the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as a cognitive dysfunction screening tool. The Alzheimer Disease 8 (AD8) and Subjective...
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Different Cortical Thinning Patterns Depending on Their Prognosis in Individuals with Subjective Cognitive Decline

Lim EY, Shim YS, Hong YJ, Ryu SY, Cho AH, Yang DW

BACKGROUND AND PURPOSE: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in...
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Direct and Indirect Costs of Chronic Obstructive Pulmonary Disease in Korea

Kim C, Kim Y, Yang DW, Rhee CK, Kim SK, Hwang YI, Park YB, Lee YM, Jin S, Park J, Hahm CR, Park CH, Park SY, Jung CK, Kim YI, Lee SH, Yoon HK, Lee JH, Lim SY, Yoo KH

BACKGROUND: Understanding the burden of disease is important to establish cost-effective treatment strategies and to allocate healthcare resources appropriately. However, little reliable information is available regarding the overall economic burden...
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Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data

Choi GS, Kim GH, Choi JH, Hwang J, Kwon E, Lee SA, Kong KA, Kang HJ, Yoon B, Kim BC, Yang DW, Na DL, Kim EJ, Na HR, Han HJ, Lee JH, Kim JH, Lee KY, Park KH, Park KW, Kim S, Han SH, Kim SY, Yoon SJ, Moon SY, Youn YC, Choi SH, Jeong JH

BACKGROUND AND PURPOSE: Visual assessment of medial temporal-lobe atrophy (MTA) has been quick, reliable, and easy to apply in routine clinical practice. However, one of the limitations in visual assessments...
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Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia

Lim EY, Yang DW, Kim JS, Cho AH

BACKGROUND: There are debates on representation and generalizability of previous randomized controlled trials about anti-dementia agents in the oldest old population. In this context, we aimed to investigate the efficacy...
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Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort

Shim YS, Yang DW, Yoon B, Lee Y, Hong CH, Seo SW, Yoon SJ, Jeong JH, Park MH, Choi SH, Kim SY

BACKGROUND AND PURPOSE: Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify...
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Molecular Description of Macroorchis spinulosus (Digenea: Nanophyetidae) Based on ITS1 Sequences

Won EJ, Kim DG, Cho J, Jung BK, Kim MJ, Yun YW, Chai JY, Ryang DW

We performed a molecular genetic study on the sequences of 18S ribosomal RNA (ITS1 region) gene in 4-day-old adult worms of Macroorchis spinulosus recovered in mice experimentally infected with metacercariae...
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Blood Pressure and Heart Rate Variability in Alzheimer's Disease

Kim JS, Park HE, Oh YS, An JY, Park SK, Han SR, Park JW, Yang DW, Shim YS, Lee KS

BACKGROUND AND PURPOSE: Altered blood pressure (BP) and heart rate variations (HRVs) have been reported in Alzheimer's disease (AD). However, it is unclear how these two manifestations are associated with...
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Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea

Won EJ, Kim J, Shin MG, Shin JH, Suh SP, Ryang DW

We investigated the seroepidemiological, clinical, and laboratory characteristics of patients suspected to have toxocariasis in Gwangju and Jeonnam-province, Korea. In total, 228 specimens were analyzed for anti-Toxocara canis IgG at...
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Evaluation of Modified Formalin-Ether Concentration Method Using Para Tube in Clinical Settings

Won EJ, Kim J, Ryang DW

Conventional formalin-ether concentration method is a gold standard for the diagnosis of parasite infection. However, it may be time-consuming and laborious. We aimed to reveal the clinical usefulness of a...
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Comparison of FcRgamma-Deficient and CD57+ Natural Killer Cells Between Cord Blood and Adult Blood in the Cytomegalovirus-Endemic Korean Population

Baek HJ, Kim DW, Phan MT, Kim JS, Yang JH, Choi JI, Lee JJ, Shin MG, Ryang DW, Kim SK, Lee SH, Kook H, Cho D

BACKGROUND: FcRgamma-deficient natural killer (NK) cells (g-NK cells) have been associated with cytomegalovirus (CMV) infection. However, the frequency of g-NK cells in a CMV-endemic area (i.e., Korea) has not yet...
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The Effects of Occupational Therapy and Music Therapy on Patients With Mild Cognitive Impairment: A Pilot Study

Lim EY, Yang DW, Shim YS, Yoon B, Hong YJ, Moon MS

BACKGROUND: Patients with mild cognitive impairment (MCI) are at an increased risk for developing dementia, especially Alzheimer disease; and pharmacological therapy for MCI is limited. As a result, nonpharmacological mediums...
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Comparison of AdvanSure TB/NTM PCR and COBAS TaqMan MTB PCR for Detection of Mycobacterium tuberculosis Complex in Routine Clinical Practice

Cho WH, Won EJ, Choi HJ, Kee SJ, Shin JH, Ryang DW, Suh SP

The AdvanSure tuberculosis/non-tuberculous mycobacterium (TB/NTM) PCR (LG Life Science, Korea) and COBAS TaqMan Mycobacterium tuberculosis (MTB) PCR (Roche Diagnostics, USA) are commonly used in clinical microbiology laboratories. We aimed to...
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Strongyloidiasis in a Diabetic Patient Accompanied by Gastrointestinal Stromal Tumor: Cause of Eosinophilia Unresponsive to Steroid Therapy

Won EJ, Jeon J, Koh YI, Ryang DW

We report here a case of strongyloidiasis in a 72-year-old diabetic patient (woman) accompanied by gastrointestinal stromal tumor receiving imatinib therapy, first diagnosed as hypereosinophilic syndrome and treated with steroids...
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Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer's Disease

Na HR, Park MH, Kim S, Yang DW, Choi SH, Yang HD, Yang Y, Han HJ, Lee JS, Yoon YC, Koh SH, Kim JE, Ku BD, Kim HJ, Park KW, Kim EJ, Yoon B, Park KJ

BACKGROUND AND PURPOSE: The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patients show more side effects than those in Western countries. We evaluated...
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