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Isolation and molecular characterizations of canine distemper virus from a naturally infected Korean dog using Vero cells expressing dog signaling lymphocyte activation molecule

Yang DK, Kim HH, Lee S, Yoon YS, Park J, Oh D, Yoo JY, Ji M, Han B, Oh S, Hyun BH

Background: Canine distemper virus (CDV) infection results in high morbidity and mortality in dogs. There has been no report about Isolation of Korean CDV since 1980 in Korea. Objectives: To investigate...
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Genotype-specific neutralizing antibody titers against Japanese encephalitis virus genotypes 1 and 3 in horses immunized with a genotype 3 vaccine

Kim HH, Yang DK, Ji M, Lee SK, Hyun BH

Purpose: Japanese encephalitis is one of the most important mosquito-borne and zoonotic diseases in Asia and the Pacific region. Although the dominant Japanese encephalitis virus (JEV) genotype has shifted from...
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Development of indirect ELISA for the detection of canine adenovirus type 2 antibodies in dog sera

Yang DK, Kim HH, Lee S, Oh D, Yoo JY, Hyun BH

Background: Canine adenovirus type 2 (CAV-2) induces infectious laryngotracheitis in members of the family Canidae, including dogs. To date, no ELISA kits specific for CAV-2 antibody have been commercialized for...
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Evaluation of Commercial Immunochromatographic Test Kits for the Detection of Canine Distemper Virus

Yang DK, Kim HH, Lee J, Ji M, Oh S, Lee HS, Hyun BH

The rapid diagnosis of canine distemper virus (CDV) helps to determine the treatment of dogs in veterinary clinics. We evaluated the performance of seven commercial rapid immunochromatographic test (RICT) kits...
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Establishment of multiplex RT-PCR for differentiation between rabies virus with and that without mutation at position 333 of glycoprotein

Yang DK, Kim HH, Lee S, Yoo JY

Rabid raccoon dogs (Nyctereutes procyonoides koreensis) have been responsible for animal rabies in South Korea since the 1990s. A recombinant rabies vaccine strain, designated as ERAGS, was constructed for use...
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Development of an Indirect ELISA Featuring Plates Coated with Column Chromatographically Purified Canine Adenovirus Type-1 Antigen

Yang DK, Kim HH, Lee S, Ji M, Han BH, Oh S, Hyun BH

Canine adenovirus type 1 (CAV-1) causes infectious hepatitis in members of the family Canidae, including dogs. An indirect enzyme-linked immunosorbent assay (I-ELISA) that detects CAV-1 antibodies is required for large-throughput...
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Isolation and Molecular Characterization of Feline Herpesvirus 1 from Naturally Infected Korean Cats

Yang DK, Kim HH, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim J, Kim HJ, Lee J, Hyun BH

Feline herpesvirus type 1 (FHV-1) causes respiratory and ocular disease in cats. Although isolates of FHV-1 circulating in cats have been reported worldwide, Korean FHV-1 isolates and their features have not...
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Biological and molecular characterization of feline caliciviruses isolated from cats in South Korea

Yang DK, Park YR, Yoo JY, Choi SS, Park Y, An S, Park J, Kim HJ, Kim J, Kim HH, Hyun BH

Feline calicivirus (FCV) infection results in a common upper respiratory disease associated with oral ulceration in cats. Although FCV infection has been reported in cats worldwide, the biologic and genetic features...
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Immunogenicity of a new, inactivated canine adenovirus type 2 vaccine for dogs

Yang DK, Kim HH, Yoo JY, Ji M, Han BH, Oh S, Hyun BH

PURPOSE: We constructed a new canine adenovirus type 2 (CAV-2) vaccine candidate using the recently isolated Korean CAV-2 strain; we termed the vaccine APQA1701-40P and evaluated its safety and immunogenicity...
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Recharacterization of the Canine Adenovirus Type 1 Vaccine Strain based on the Biological and Molecular Properties

Yang DK, Kim HH, Lee EJ, Yoo JY, Yoon SS, Park J, Kim CH, Kim HR

Canine adenovirus type 1 (CAV-1) infection results in hepatitis in dogs. In this study, we investigated the biologic and genetic characteristics of the CAV-1 vaccine strain (CAV1V) to improve quality...
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Rabies immune status of raccoon dogs residing in areas where rabies bait vaccine has been distributed

Yang DK, Kim HH, Lee EJ, Yoo JY, Kim JT, Ahn S

Since 2000, large amounts of rabies bait vaccine have been distributed in two provinces where raccoon dog-mediated rabies has occurred. A total of 146 raccoon dogs were caught in Gangwon...
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Incidence and Sero-survey of Canine Adenovirus Type 2 in Various Animal Species

Yang DK, Kim HH, Yoon SS, Ji M, Cho IS

Canine adenovirus type 2 (CAV-2) is the cause of a major respiratory illness in dogs. In this study, we analyzed adenovirus infections in dogs using 2000–2017 data from the Animal...
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Strategies to maintain Korea's animal rabies non-occurrence status

Yang DK, Kim HH, Cho IS

Endemic animal rabies causes >99% of all human rabies cases; elimination of animal rabies reduces the rate of human infections. The most recent animal rabies cases in the Gangwon and...
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Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats

Yang DK, Kang HS

Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed....
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Isolation and identification of canine adenovirus type 2 from a naturally infected dog in Korea

Yang DK, Kim HH, Yoon SS, Lee H, Cho IS

Canine adenovirus type 2 (CAV-2) infection results in significant respiratory illness in dogs. Isolating and culturing CAV-2 allows for investigations into its pathogenesis and the development of vaccines and diagnostic...
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Isolation and characterization of a new porcine epidemic diarrhea virus variant that occurred in Korea in 2014

Yang DK, Kim HH, Lee SH, Yoon SS, Park JW, Cho IS

Outbreaks of porcine epidemic diarrhea (PED) have resulted in significant economic losses in the swine industry, and another PED outbreak occurred in 2014 in Korea. Isolating and culturing PED virus...
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Efficacy of inactivated variant porcine epidemic diarrhea virus vaccines in growing pigs

Lee SH, Yang DK, Kim HH, Cho IS

PURPOSE: The first aim of this study was to develop a novel inactivated porcine epidemic diarrhea virus (PEDV) vaccine using the recently isolated Korean PEDV QIAP1401 strain and to evaluate...
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Isolation and identification of Moraxella cuniculi from a rabbit with keratoconjunctivitis

Yang DK, Kim HH, Yoo JY, Lim SK, Yoon SS, Cho IS

A Gram-negative, catalase- and oxidase-positive, coccus-shaped bacterium was isolated from a rabbit with keratoconjunctivitis. Colonies of the isolate were round, smooth, and exhibited hemolytic activity on 5% sheep blood agar....
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Indirect ELISA for the Detection of Rabies Virus Antibodies in Dog Sera

Yang DK, Kim HH, Lee SH, Ji M, Cho IS

Rabies is known as the most fatal disease in all warm-blooded animals, including dogs. Among animals that transmit rabies, dogs are mainly responsible for transmitting animal rabies in Asian countries....
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A genetically modified rabies vaccine (ERAGS) induces protective immunity in dogs and cattle

Yang DK, Kim HH, Lee SH, Jeong WH, Tark D, Cho IS

PURPOSE: The current live attenuated rabies vaccine must be replaced with a safer vaccine based on the ERAGS strain to prevent rabies in South Korea. We evaluated the safety and...
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