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Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy

Cui S, Luo K, Quan Y, Lim SW, Shin YJ, Lee KE, Kim HL, Ko EJ, Kim JH, Chung SJ, Bae SK, Chung BH, Yang CW

Background/Aims: Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble...
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Impact of high body mass index on allograft outcomes in kidney transplant recipients with presensitization to human leukocyte antigen

Park Y, Lee H, Ko EJ, Lee S, Ban TH, Min JW, Yoon HE, Oh EJ, Yang CW, Chung BH

Background: This study aimed to investigate whether high body mass index (BMI) and presensitization to human leukocyte antigen (HLA) in kidney transplant recipients (KTRs) affected allograft outcomes. Methods: From January 2010...
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Impact of acute kidney injury in deceased donors with high Kidney Donor Profile Index on posttransplant clinical outcomes: a multicenter cohort study

Park WY, Chang YK, Kim YS, Jin K, Yang CW, Han S, Chung BH

Background: This study evaluated the impact of acute kidney injury (AKI) on posttransplant clinical outcomes for deceased donor (DD) kidney transplantation (KT) using the Kidney Donor Profile Index (KDPI) system....
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L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Zhao HY, Li HY, Jin J, Jin JZ, Zhang LY, Xuan MY, Jin XM, Jiang YJ, Zheng HL, Jin YS, Jin YJ, Choi BS, Yang CW, Piao SG, Li C

Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on...
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Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy

Park Y, Ban TH, Kim HD, Ko EJ, Lee J, Kim SC, Park CW, Yang CW, Kim YS, Chung BH

Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Methods: This study enrolled 169 patients...
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Cellular and genetic signatures of operational tolerance in kidney transplant recipients through single cell RNA sequencing analysis

Bae H, Lee H, Ryu JH, Jang JH, Lee J, Ko GY, Yang CW, Chung BH, Oh EJ

Background: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results as stable patients with immunosuppressants. We analyzed differently expressed mRNAs and proteins...
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Intra-patient variability in tacrolimus trough levels over 2 years affects long-term allograft outcomes of kidney transplantation

Park Y, Lee H, Eum SH, Kim HD, Ko EJ, Yang CW, Chung BH

Background: The current study aimed to determine the impact of tacrolimus (TAC) trough level (C0) intra-patient variability (IPV) over 2 years after kidney transplantation (KT) on allograft outcomes. Methods: In total,...
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Changing patterns of T lymphocyte subsets after kidney transplantation according to induction immunosuppressant: single center prospective observational study

Kim HD, Bae H, Eum SH, Lee H, Ko EJ, Yang CW, Oh EJ, Chung BH

Background: The aim of this study is to investigate the changing patterns of T cell subsets during early post-transplant period according to the type of induction therapy (anti-thymocyte globulin [ATG]...
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Comparison of the impact between peak mean fluorescent intensity versus sum of mean fluorescent intensity value of donor specific anti-human leukocyte antigen antibody on the posttransplant clinical outcomes

Kim HD, Park Y, Eum SH, Lee H, Ko EJ, Yang CW, Chung BH

Background: In this study, we investigated to verify which of the peak value of donor-specific human leukocyte antigen antibodies (DSA) mean fluorescent intensity (MFI) and sum of MFI had higher...
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Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients

Bae H, Na DH, Chang JY, Park KH, Min JW, Ko EJ, Lee H, Yang CW, Chung BH, Oh EJ

Background/Aims To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods We...
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The differential effects of anemia on mortality in young and elderly end-stage renal disease patients

Ko EJ, Kim YK, Cho JH, Kim YS, Kang SW, Kim NH, Kim YL, Yang CW, Chung BH

Background: The aim of this study was to compare the effect of anemia on clinical outcomes according to age in patients with end-stage renal disease (ESRD). Methods: A total of 3,409...
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Recurrent Severe Hyponatremia in a Patient with Sjögren’s Syndrome

Kim HD, Lee J, Chung BH, Yang CW, Kim YS, Park CW

Sjögren's syndrome (SS) is an autoimmune disease that presents with exocrine gland dysfunction. Renal involvement is common in SS and often results in tubulointerstitial nephritis, renal tubular acidosis, and Fanconi’s...
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Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literature

Lee S, Lee HY, Park Y, Ko EJ, Ban TH, Chung BH, Lee HS, Yang CW

Chaga mushrooms are widely used in folk remedies and in alternative medicine. Contrary to many beneficial effects, its adverse effect is rarely reported. We here report a case of end-stage...
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Amyloid light-chain amyloidosis presented as focal segmental glomerulosclerosis in a kidney transplant recipient

Park SH, Kwon SH, Lee HY, Lee S, Ko EJ, Ban TH, Chung BH, Choi YJ, Yang CW

Amyloid light-chain (AL) amyloidosis after kidney transplantation is a rare disease in the world, and only one case of systemic AL amyloidosis after kidney transplantation is reported in Korea. We...
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Assessment of nephrotoxicity of herbal medicine containing aristolochic acid in mice

Quan Y, Jin L, Luo K, Jin J, Lim SW, Shin YJ, Ko EJ, Chung BH, Yang CW

Background/Aims: It is undetermined if herbal medicines (HM) containing aristolochic acid (AA)-containing have similar nephrotoxicity to AA itself. Methods: We administered HM containing a high concentration of AA for 5 days...
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Acute allograft dysfunction mimicking thrombotic microangiopathy in kidney transplant recipient with renal infarction: case report and review of literatures

Lee S, Ho LY, Chung BH, Park SC, Yang CW

Acute allograft dysfunction is rarely observed in kidney transplantation (KT). We report an unusual case of acute allograft dysfunction mimicking thrombotic microangiopa- thy (TMA) in recipient with renal infarction. A 65-year-old man...
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Differential impact of allograft rejection on kidney transplant patients with BK virus infection

Min JW, Park JB, Park JH, Park JW, Yang J, Ahn C, Yang CW, Chung BH

Background: BK virus-associated nephropathy (BKVAN) is a known risk factor for allograft dysfunction and graft failure in kidney transplant recipients. The mainstay of treatment for BKVAN is reduction of immunosuppression...
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Usefulness of pre- and post-transplant BK virus-specific ELISPOT assay for predicting the outcome of BK virus infection in kidney transplant recipients

Ko EJ, Bae H, Park KH, Yang CW, Chung BH, Oh EJ

Background: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay at pre- and post-transplant can predict the outcome of BKV infection in kidney...
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The clinical utility of preformed C1q-binding donor-specific anti-HLA antibodies in kidney transplantation

Lee S, Yang CW, Chung BH

Background: The role of C1q-binding donor-specific antibody (DSA) in antibody-mediated rejection (AMR) is considered important. De novo C1q-binding DSA is well known as an associated factor for increased risk of...
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The clinical impact of preformed human leukocyte antigen-DQ donor-specific antibodies on graft outcomes in kidney transplantation

Lee S, Chung BH, Yang CW

Background: De-novo human leukocyte antigen (HLA)-DQ donor-specific antibody (DSA) is well known as a risk factor for graft dysfunction and graft loss in kidney transplantation (KT). Recently, the influence of...
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