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Diagnostic Algorithm for the Rapid and CostEffective Detection of Clostridioides difficile Infection: Comparison between C. DIFF QUIK CHEK COMPLETE and VIDAS GDH & Toxin Assay

Yoo SJ, Whang DH

Background: We evaluated the analytical performance and cost-effectiveness of lateral flow immunoassays (LFIAs) in detecting Clostridioides difficile glutamate dehydrogenase (GDH) antigen and toxin A/B, followed by a rapid nucleic...
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Rapid and accurate diagnosis of Clostridium difficile infection by real-time polymerase chain reaction

Song PH, Min JH, Kim YS, Jo SY, Kim EJ, Lee KJ, Lee J, Sung H, Moon JS, Whang DH

BACKGROUND/AIMS: The incidence and severity of Clostridium difficile infection (CDI) have increased worldwide, resulting in a need for rapid and accurate diagnostic methods. METHODS: A retrospective study was conducted to compare...
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Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery

Park SJ, Koo H, Lee KJ, Kim SH, Yun SY, Kim S, Whang DH, Joo SY, Lee B, Chin H, Park S

OBJECTIVES: The neutrophil gelatinase-associated lipocalin (NGAL) level following non cardiac surgery is useful for predicting acute kidney damage. However, there is insufficient conclusive evidence as to whether NGAL can be...
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Evaluation of the VIDAS Anti-HCV Assay for Detection of Hepatitis C Virus Infection

Hyun J, Ko DH, Kang HJ, Whang DH, Cha YJ, Kim HS

BACKGROUND: Anti-hepatitis C virus antibody (anti-HCV) assays are recommended for screening HCV-infected persons. The VIDAS Anti-HCV Assay (bioMérieux, France), based on the enzyme-linked fluorescence test principle, was recently introduced in...
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Evaluation of Centaur Syphilis, Immulite Syphilis, and Mediace TPLA for Detecting Treponemal Antibodies

Seo DH, Whang DH, Joo SY, Choi HH

BACKGROUND: We evaluated the efficacy of two chemiluminescence immunoassays that detect treponemal antibodies, Centaur Syphilis and Immulite Syphilis, in comparison with Mediace Treponema pallidum latex agglutination (TPLA). METHODS: The study was...
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Higher Prevalence of Klebsiella pneumoniae Extended-Spectrum beta-Lactamase in Patients on Renal Replacement Therapy

Lee HL, Whang DH, Park DW, Lee YJ, Kim YH, Chin HJ, Kim S, Koo HS

The prevalence of antibiotic resistance is higher in patients undergoing renal replacement therapy (RRT) than in patients who did not undergo RRT. We investigated the presence of KP (Klebsiella pneumoniae)...
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Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Korea, and the Activity of Antimicrobial Combinations against the Isolates

Chung HS, Hong SG, Kim YR, Shin KS, Whang DH, Ahn JY, Park YJ, Uh Y, Chang CL, Shin JH, Lee HS, Lee K, Chong Y

The aim of this study was to determine antimicrobial susceptibility of recent clinical Stenotrophomonas maltophilia isolates from Korea, and to compare the activity levels of several combinations of antimicrobials. A...
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Analysis of Comparability Test between Reagent Lots in Immunoassay

Kim HS, Whang DH, Kang HJ

  • KMID: 2312213
  • Lab Med Online.
  • 2012 Oct;2(4):235-239.
Lot-to-lot reproducibility is an important issue in immunoassays and reagent lot-to-lot comparability test comparing the results of new reagent lot with those of used lot using patients' samples or controls...
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Postchemotherapy Changes in Cytokine Levels and Their Correlation with Hematological Parameters in Patients with Vivax Malaria

Whang DH, Um TH, Cho CR, Kwak YK, Kim ES

  • KMID: 1848726
  • J Lab Med Qual Assur.
  • 2011 Jun;33(1):1-8.
BACKGROUND: Inflammatory cytokines play an important role in human immune responses to malaria, although the role of these mediators in pathogenesis is unclear. In this study, we evaluated changes in...
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Gender Difference in the Level of HDL Cholesterol in Korean Adults

Kim HJ, Park HA, Cho YG, Kang JH, Kim KW, Kang JH, Kim NR, Chung WC, Kim CH, Whang DH, Park JK

BACKGROUND: High density lipoprotein (HDL) cholesterol level varies with ethnicity and gender. In Korea there has not been an agreement on standards for HDL cholesterol level. Therefore, in order to...
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The Incidence and Clinical Features of Clostridium difficile Infection; Single Center Study

Lee JH, Lee SY, Kim YS, Park SW, Park SW, Jo SY, Ryu SH, Lee JH, Moon JS, Whang DH, Shin BM

BACKGROUND/AIMS: Clostridium difficile is the predominant cause of nosocomial diarrhea. Recently, the incidence of Clostridium difficile infection (CDI) increases in Europe and North America. A retrospective study was performed to...
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The Effect of Contact Precautions and Active Surveillance Culture on the Methicillin-Resistant Staphylococcus aureus Reduction in an Intensive Care Unit

Choi SM, Jeong JS, Whang DH, Woo JH

  • KMID: 2307571
  • Korean J Nosocomial Infect Control.
  • 2010 Dec;15(2):112-119.
BACKGROUND: This study investigated the effectiveness of reinforced contact precautions and active surveillance cultures (ASCs) in reducing the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and other healthcare-associated infections (HAIs). METHODS: A...
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Lot-to-lot Reagent Variation in Immunoassay: Retrospective Analysis of Daily Quality Control Results

Kim HS, Kang HJ, Whang DH, Lee SG, Park MJ, Park JY, Cho HC, Lee KM

  • KMID: 2200543
  • J Lab Med Qual Assur.
  • 2010 Dec;32(2):243-253.
BACKGROUND: Lot-to-lot reagent reproducibility is an important issue in immunoassays. However, there have been no universal criteria for acceptable lot-to-lot reproducibility. We sought to evaluate the inter-lot reagent difference by...
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Trichuris trichiura Infection Diagnosed by Colonoscopy: Case Reports and Review of Literature

Ok KS, Kim YS, Song JH, Lee JH, Ryu SH, Lee JH, Moon JS, Whang DH, Lee HK

Trichuris trichiura, commonly referred to as a whipworm, has a worldwide distribution, particularly among countries with warm, humid climates. In Korea, trichuriasis was a highly prevalent soil-transmitted helminthiasis until the...
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Differences in the Perception of Blood Transfusion Risk between Laypeople and Transfusion Experts in Korea

Um TH, Whang DH, Ha M, Cho CR

  • KMID: 2300048
  • Korean J Blood Transfus.
  • 2009 Dec;20(3):212-219.
BACKGROUND: Generally, laypeople perceive blood transfusion risk differently from experts like physicians. Acknowledging such differences may improve risk communication. This study characterized how blood transfusion experts in Korea perceive the...
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The Usefulness of the Alanine Aminotransferase Test for Blood Donors

Seo DH, Whang DH

  • KMID: 2300042
  • Korean J Blood Transfus.
  • 2009 Dec;20(3):159-166.
BACKGROUND: The usefulness of the alanine aminotransferase (ALT) test has been questioned after the introduction of anti-Hepatitis C virus (HCV) screening and the HCV nucleic acid test (NAT). A major...
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Perception of the Risks of Blood Transfusion in Koreans

Whang DH, Um TH, Ha M

BACKGROUND: The perceived risks of blood transfusions are important to be considered in creating a blood service policy. We surveyed the perception of blood transfusion risks among Korean laypeople. METHODS:...
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Effectiveness of Sodium Fluoride as a Glycolysis Inhibitor on Blood Glucose Measurement: Comparison of Blood Glucose using Specimens from the Korea National Health and Nutrition Examination Survey

Lee YW, Cha YJ, Chae SL, Song J, Yun YM, Park HI, Seong MW, Whang DH, Kim HS, Kim JH, Lee BS, Hwang YS

BACKGROUND: Accurate measurement of blood glucose concentrations is essential for defining diabetes, and the minimization of ex vivo glycolysis has been recommended. Recent guidelines advocate two kinds of methods for...
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Cost-Effectiveness of Donor Screening Strategies for Acitretin Medication

Um TH, Whang DH, Park HD, Kim JH, Ha M, Cho NS

  • KMID: 1477810
  • Korean J Blood Transfus.
  • 2008 Aug;19(2):91-99.
BACKGROUND: Donors with acitretin medication history are deferred for three years in Korea, because acitretin has teratogenic effect. Authors tried to evaluate the cost-effectiveness of the donor screening measures for...
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Linezolid Treatment for Osteomyelitis due to Staphylococcus Epidermidis with Reduced Vancomycin Susceptibility

Nam JR, Kim MS, Lee CH, Whang DH

Limited therapeutic options are available for vancomycin intermediate-resistant Staphylococcus Epidermidis (VISE) infections and no optimum therapy has been established. We report a case of VISE skull osteomyelitis that was successfully...
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