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Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke

Sapkota A, Park SJ, Choi JW

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific...
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Clustering and Switching Patterns in Semantic Fluency and Their Relationship to Working Memory in Mild Cognitive Impairment

Oh SJ, Sung JE, Choi SJ, Jeong JH

BACKGROUND AND PURPOSE: Semantic verbal fluency test is a neuropsychological assessment that can sensitively detect neuropathological changes. Considering its multifactorial features tapping various cognitive domains such as semantic memory, executive...
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Rapidly growing pediatric trampoline-related injuries in Korea: a 10-year single center retrospective study

Cho MJ, Kim J, Kim SJ, Kyoung KH, Keum MA, Park SK

PURPOSE: Several published policy statements have warned against the risks associated with trampoline use and recommended safety guidelines. However, few studies have focused on trampoline-related injuries in Korea. This study...
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Suppressor of Variegation 3–9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation

Kim AR, Sung JY, Rho SB, Kim YN, Yoon K

Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and...
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Aspergillus terreus JF27 Promotes the Growth of Tomato Plants and Induces Resistance against Pseudomonas syringae pv. tomato

Yoo SJ, Shin DJ, Won HY, Song J, Sang MK

Certain beneficial microorganisms isolated from rhizosphere soil promote plant growth and induce resistance to a wide variety of plant pathogens. We obtained 49 fungal isolates from the rhizosphere soil of...
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Nursing Strategy for Use of Seclusion and Restraint in Psychiatric Hospitals

Sung JE, Kim SJ, Kim SH, Kim SW

Although seclusion and restraint are required for the treatment of mentally ill patients in psychiatric hospitals, these procedures involve potential violations of human rights and pose a potential risk to...
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Effects of acute normovolemic hemodilution on healing of gastric anastomosis in rats

Kim TY, Kim DW, Jeong MA, Jun JH, Min SJ, Shin SJ, Ha TK, Choi D

PURPOSE: Acute normovolemic hemodilution (ANH) is an autologous transfusion method, using blood collected during surgery, to reduce the need for allogeneic blood transfusion. ANH is controversial because it may lead...
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Comparison of therapeutic responses to an anticancer drug in three stocks of ICR mice derived from three different sources

Sung JE, Kim JE, Lee HA, Yun WB, Choi JY, Lee MR, Park JJ, Kim HR, Song BR, Jung YS, Kim KS, Hwang DY

Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipation...
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Hepatotoxicity and nephrotoxicity of saponin-enriched extract of Asparagus cochinchinensis in ICR mice

Sung JE, Choi JY, Kim JE, Lee HA, Yun WB, Park JJ, Kim HR, Song BR, Kim DS, Lee CY, Lee HS, Lim Y, Hwang DY

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models....
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Hydronephrosis during Conservative Treatment for a Renal Injury Patient

Kim M, Kim J, Kim SJ, Cho HJ

A 21-year-old male visited our emergency room. He could not remember the mechanism of injury. He was found beside a motorcycle. Initial vital sign was stable. Observation and conservative treatment...
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Temporary Closure for Sternotomy in Patient with Massive Transfusion Might Be Lethal

Kim M, Kim J, Kim SJ, Cho HJ

A 58-year-old male visited our emergency room for multiple traumas from explosion. On initial evaluation, hemopneumoperitoneum with liver laceration (grade 4) and colon perforation was identified. Hemopericardium with cardiac tamponade...
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Effect of surgical timing and outcomes for appendicitis severity

Kim M, Kim SJ, Cho HJ

PURPOSE: This study was aimed to evaluate the effect of time of surgery for acute appendicitis on surgical outcomes to optimize the timing of appendectomies. METHODS: Medical records of patients who...
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Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Koh EK, Yun WB, Kim JE, Song SH, Sung JE, Lee HA, Seo EJ, Jee SW, Bae CJ, Hwang DY

To investigate the beneficial effects of diosgenin (DG) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were...
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Ideal Time to Surgery for Acute Abdomen

Kim M, Kim JH, Kim SJ, Cho HJ

Timing of surgery is important for prognosis. In patients with acute abdomen, the urgency means timing of surgery is even more important. However early emergency surgery is often logistically daunting...
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Comparison of the response using ICR mice derived from three different sources to ethanol/hydrochloric acid-induced gastric injury

Song SH, Kim JE, Go J, Koh EK, Sung JE, Lee HA, Choi KM, Kim HD, Jung YS, Kim KS, Hwang DY

Animal models for gastric ulcers produced by physical, pharmacological and surgical methods have been widely employed to evaluate therapeutic drugs and investigate the mechanism of action of this disease. ICR...
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Therapeutic effect of ethyl acetate extract from Asparagus cochinchinensis on phthalic anhydride-induced skin inflammation

Sung JE, Lee HA, Kim JE, Go J, Seo EJ, Yun WB, Kim DS, Son HJ, Lee CY, Lee HS, Hwang DY

Asparagus cochinchinensis has been used to treat various diseases including fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease, while IL-4 cytokine has been considered as key regulator...
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Laxative effects of Liriope platyphylla are tightly correlated with suppression of endoplasmic reticulum stress in loperamide-induced constipation of SD rats

Kim JE, Go J, Sung JE, Lee HA, Seo EJ, Yun WB, Hwang DY

A dysfunction of endoplasmic reticulum (ER) stress response can result in various diseases, including cancer, inflammation, diabetes and neurodegenerative disorders. To investigate whether ER stress response can play an essential...
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Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Yun WB, Park JJ, Kim JE, Sung JE, Lee HA, Lee JH, Bae CJ, Hwang DY

Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the...
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Characterization the response of Korl:ICR mice to loperamide induced constipation

Kim JE, Yun WB, Sung JE, Lee HA, Choi JY, Choi YS, Jung YS, Kim KS, Hwang DY

Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected...
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Toxicity of antioxidative extract collected from Styela clava tunics in ICR mice

Koh EK, Sung JE, Kim JE, Go J, Song SH, Lee HA, Son HJ, Jung YJ, Lim Y, Hwang DY

Some polymers and bioactive compounds derived from Styela clava tunic (SCT) have been reported as traditional medicine for the treatment of inflammation, oxidative stress and surgical wounds although there is...
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