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Long-term Efficacy of S-1 Monotherapy or Capecitabine Plus Oxaliplatin as Adjuvant Chemotherapy for Patients with Stage II or III Gastric Cancer after Curative Gastrectomy: a Propensity Score-Matched Multicenter Cohort Study

Lee CM, Yoo MW, Son YG, Oh SJ, Kim JH, Kim HI, Park JM, Hur H, Jee YS, Hwang SH, Jin SH, Lee SE, Park JH, Seo KW, Park S, Kim CH, Jeong IH, Lee HH, Choi SI, Lee SI, Kim CY, Kim IH, Son MW, Pak KH, Kim S, Lee MS, Min JS

Purpose: To compare long-term disease-free survival (DFS) between patients receiving tegafur/gimeracil/oteracil (S-1) or capecitabine plus oxaliplatin (CAPOX) adjuvant chemotherapy (AC) for gastric cancer (GC). Materials and Methods: This retrospective multicenter observational...
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Current Status of Bariatric and Metabolic Surgery in Daejeon and Chungcheong Province: Early Experiences after Public Medical Insurance Coverage in 2019

Kim DW, Kim DH, Kim JG, Son MW, Song GJ, Oh Si, Yoo HM, Lee MS, Lee SK, Lee SE, Jee YS, Hwang SH, Hwang SE, Lee SI

Purpose: This study aimed to investigate the current status of bariatric and metabolic surgery in Daejeon and Chungcheong province and to describe the early experiences after public medical insurance coverage...
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A Case of a Patent Omphalomesenteric Duct Presenting with Meconium Discharge from the Umbilicus

Han CH, Son MW, Song JH

The omphalomesenteric duct is a link between the primitive midgut and the yolk sac. Normally, the duct obliterates around 6 weeks of gestation, yet varying degrees of incomplete obliteration can...
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Who Can Perform Adjuvant Chemotherapy Treatment for Gastric Cancer? A Multicenter Retrospective Overview of the Current Status in Korea

Min JS, Lee CM, Choi SI, Seo KW, Park DJ, Baik YH, Son MW, Choi WH, Kim S, Pak KH, Kim MG, Park JM, Jeong SH, Lee MS, Park S

PURPOSE: To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and the difference in efficacy of AC administered by surgical and medical oncologists in patients with stage...
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CORRIGENDUM: Correction of funding statement in ACKNOWLEDGEMENTS section: Epigenetic inactivation of RUNX3 in colorectal cancer

Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ

Correction of funding statement in ACKNOWLEDGEMENTS section.
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Feasibility of Single-Incision Laparoscopic Appendectomy in Pregnant Women

Son MW, Song GJ, Lee MS

OBJECTIVE: Owing to advances in laparoscopic technique and equipment, a single-port laparoscopic surgery has been applied in various fields of surgery. However, the application of a single-port laparoscopic surgery for...
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Current Status of Metabolic and Bariatric Surgery in Daejeon/Chungcheong Area

Kim DW, Kim DH, Kim JG, Son MW, Song GJ, Oh SI, Yoo HM, Lee MS, Lee SK, Lee SI, Jee YS, Hwang SE, Lee SE

PURPOSE: The aim of our study is to investigate the current status of metabolic and bariatric surgery in Daejeon and Chungcheong province and examine the role and necessity of the...
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Clinical relevance of Lgr5 expression in colorectal cancer patients

Kim YJ, Kang DH, Song GJ, Ahn TS, Son MW, Lee MS, Baek MJ

PURPOSE: Lgr5 is a well-known stem cell marker in colorectal cancer (CRC). This retrospective study evaluated the expressions of Lgr5 in CRC specimens, and examined whether these expressions were associated...
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Epigenetic inactivation of RUNX3 in colorectal cancer

Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ

PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3...
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Prevalence of Malnutrition in Hospitalized Patients: a Multicenter Cross-sectional Study

Kang MC, Kim JH, Ryu SW, Moon JY, Park JH, Park JK, Park JH, Baik HW, Seo JM, Son MW, Song GA, Shin DW, Shin YM, Ahn HY, Yang HK, Yu HC, Yun IJ, Lee JG, Lee JM, Lee JH, Lee TH, Yim H, Jeon HJ, Jung K, Jung MR, Jeong CY, Lim HS, Hong SK, the Korean Society for Parenteral and Enteral Nutrition (KSPEN) Clinical Research Groups

BACKGROUND: Malnutrition is associated with many adverse clinical outcomes. The present study aimed to identify the prevalence of malnutrition in hospitalized patients in Korea, evaluate the association between malnutrition and...
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Programmed death-1 (PD-1) ligand 1 and PD-1 ligand 2 expressions and their clinical relevance in colorectal cancer

Ahn JH, Lee HY, Kang DH, Song GJ, Ahn TS, Son MW, Lee MS, Baek MJ

PURPOSE: Programmed death-1 and its ligands (PD-L1 and PD-L2) can induce T-cell apoptosis in many solid tumors, although there is limited information regarding their roles in colorectal cancer. METHODS: We used...
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Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer

Son MW, Song GJ, Jang SH, Hong SA, Oh MH, Lee JH, Baek MJ, Lee MS

PURPOSE: The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate...
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Clinicopathological Significance of Elevated PIK3CA Expression in Gastric Cancer

Jang SH, Kim KJ, Oh MH, Lee JH, Lee HJ, Cho HD, Han SW, Son MW, Lee MS

PURPOSE: PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated PIK3CA expression in gastric cancer and explored the relationships between...
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Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer

Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS

PURPOSE: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the...
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Expression and clinical significance of defensin alpha 6 in colorectal cancer

Park S, Ahn T, Lee H, Jeong DJ, Jeong HI, Son MW, Lee MS, Baek MJ

PURPOSE: Defensin alpha 6 (DEFA6) is cationic short peptide with known functional activities in innate antimicrobial immunity. DEFA6 is also highly expressed in colorectal cancer tissue. The mechanism and function...
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Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice

Moon E, Lee SO, Kang TH, Kim HJ, Choi SZ, Son MW, Kim SY

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model....
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Long-Term Outcomes of Proximal Gastrectomy versus Total Gastrectomy for Upper-Third Gastric Cancer

Son MW, Kim YJ, Jeong GA, Cho GS, Lee MS

PURPOSE: There are two surgical procedures for proximal early gastric cancer (EGC): total gastrectomy (TG) and proximal gastrectomy (PG). This study aimed to compare the long-term outcomes of PG with...
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Red ginseng extract increases the functional components of silkworm Bombyx mori L. used as an anti-diabetes medicinal resource

Son MW, Moon DI, Shin EH, Oh HG, Hong S, Han SJ, Lee HA, Chung YH, Kim O

  • KMID: 2055095
  • J Biomed Res.
  • 2013 Mar;14(1):40-46.
The anti-diabetes mechanism of silkworm Bombyx mori L. powder and extracts was found to inhibit the activity of alpha-glycosidase. The major functional component of silkworm powder was 1-deoxynojirimycin (1-DNJ), which...
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Clinicopathologic change of gastrointestinal stromal tumor after neoadjuvant imatinib followed by surgical resection

Kang GH, Son MW, Han SW, Bae SH, Kim SY, Kim YJ, Chung GA, Cho GS, Lee MS, Park NK

A 53-year-old woman was diagnosed with gastrointestinal stromal tumor (GIST) of the stomach. Computed tomography (CT) revealed a huge mass (12 cm in diameter), likely to invade pancreas and spleen....
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Stromal-cell-derived Factor 1-alpha Promotes Tumor Progression in Colorectal Cancer

Park SJ, Ahn TS, Cho SW, Kim CJ, Jung DJ, Son MW, Bae SH, Shin EJ, Lee MS, Kim CH, Baek MJ

PURPOSE: Although stromal-cell-derived factor (SDF)-1alpha is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined...
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