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Survey of physicians' views on the clinical implementation of pharmacogenomics-based personalized therapy

Kim WY, Kim HS, Oh M, Shin JG

Despite quantitative increases and qualitative advances in pharmacogenomics (PGx) research, the clinical implementation of PGx-based personalized therapy has still been limited. The objective of this study was to assess physicians'...
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Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test

Kim EY, Kim MY, Park CS, Choi JH, Ghim JL, Kim HS, Shin JG

Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We...
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Prediction and visualization of CYP2D6 genotype-based phenotype using clustering algorithms

Kim EY, Shin SG, Shin JG

This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined...
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Allopurinol-induced severe cutaneous adverse reactions: A report of three cases with the HLA-B*58:01 allele who underwent lymphocyte activation test

Kim EY, Seol JE, Choi JH, Kim NY, Shin JG

Allopurinol-induced severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome are reportedly associated with the...
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Gender-Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population

Shin JG, Kim JH, Park CS, Kim BJ, Kim JW, Choi IG, Hwang J, Shin HD, Woo SI

PURPOSE: Schizophrenia is a devastating mental disorder and is known to be affected by genetic factors. The chromogranin B (CHGB), a member of the chromogranin gene family, has been proposed...
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A Case of Intramural Hematoma of the Esophagus Mimicking Acute Coronary Syndrome

Ryu DG, Choi CW, Kang DH, Kim HW, Jeong DI, Kim WC, Shin JG, Lim TW

Intramural hematoma of the esophagus is a rare condition that can be spontaneous or secondary to trauma, toxic ingestion, or intervention. If it is the spontaneous type, it usually presents...
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Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections

Kim YK, Jung JA, Choi HK, Bae IG, Choi WS, Hur J, Jin SJ, Kim SW, Kwon KT, Lee SR, Shin JG, Kiem S, Pharmacokinetics-Pharmacodynamics of Antibiotics Working Group under Korean Society for Chemotherapy

BACKGROUND: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients’ characteristics, including race. The aim of this study was to investigate...
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Development and validation of a HPLC-UV method for 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in humans: providing in vivo evidence of CYP3A4-mediated CPHP formation

Park JY, Shin JG

We developed a high-performance liquid chromatographic procedure for the determination of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in human. Chromatographic analysis was performed on a reverse-phase C₁₈ column with...
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HLA-A*24:02/B*51:01 haplotype and lamotrigine-induced cutaneous adverse drug reactions in Koreans

Kim EY, Ji KH, Kim HJ, Jung HE, Cha EY, Shin JG

Antiepileptic drugs (AEDs) have been known to induce cutaneous adverse drug reaction (cADR), ranging from a mild maculopapular eruption (MPE) to potentially life-threatening cADRs such as Stevens–Johnson syndrome (SJS) and...
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Effects of mirodenafil on the hemodynamics in hypertensive patients taking amlodipine

Choi HK, Shim EJ, Shon J, Jung JA, Ghim JL, Ryu JH, Bae KS, Shin JG

While phosphodiesterase type 5 inhibitors have been used for erectile dysfunction with acceptable safety profile, they can induce orthostatic hypotension in patients taking antihypertensive drugs with blood pressure lowering effect....
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Brief introduction to current pharmacogenomics research tools

Cha EY, Jeong HE, Kim WY, Shin HJ, Kim HS, Shin JG

There is increasing interest in the application of personalized therapy to healthcare to increase the effectiveness of and reduce the adverse reactions to treatment. Pharmacogenomics is a core element in...
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Reversible Leukoencephlaopathy Caused by Doxifluridine in a Patient with Gastric Cancer

Oh SI, Ryu YS, Kim HS, Shin JG, Kim SJ

Doxifluridine neurotoxicity is more rare than 5-FU neurotoxicity. We report a case of leukoencephalopathy caused by long-term use of doxifluridine and which was resolved after discontinuation. A 37-year-old woman who...
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Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB

Lee SH, Seo KA, Lee YM, Lee HK, Kim JH, Shin C, Ghim JR, Shin JG, Kim DH

PURPOSE: Low serum concentrations of drugs used to treat multi-drug resistant tuberculosis (MDR-TB) have occasionally been associated with treatment failure. We determined the frequencies of low serum concentrations of anti-MDR-TB...
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Genetic Polymorphisms of the Carboxylesterase 1 (CES1) Gene in a Korean Population

Cha YJ, Jeong HE, Shin JG, Kim EY, Yu KS, Cho JY, Yoon SH, Lim KS

  • KMID: 2317856
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):30-34.
Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyzes various exogenous compounds. Single nucleotide polymorphisms (SNPs) of CES1 may lead to inter-individual metabolic variability of its substrates. The allele...
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Primary Pure Squamous Cell Carcinoma Originating from the Stomach

Kim JH, Hwang JH, Hwang SH, Lee SH, Lee JN, Cheung JH, Han DH, Shin JG

Primary gastric squamous cell carcinoma represents a rare entity. Up to date, only seven cases have been reported in Korea. This paper reports a case of a 51-year-old male patient...
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Negative Pressure Pulmonary Edema Together with Pneumopericardium after General Anesthesia

Hwang CG, Choi JH, Kim HJ, Jang SP, Shin JG, Han DH, Yang MJ

  • KMID: 2269312
  • Korean J Med.
  • 2014 May;86(5):612-617.
Negative pressure pulmonary edema is an uncommon complication related to general anesthesia. Its main pathophysiology is excessive negative intrathoracic pressure that is caused by an acute upper airway obstruction. Pneumopericardium,...
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A Case of Midazolam Anaphylaxis

Shin JG, Hwang JH, Lee BS, Park HJ, Lee SH, Lee JN, Han DH, Kim JH

Midazolam is a type of anesthetic agent frequently used for conscious sedation during a variety of medical procedures. Anaphylactic reactions to midazolam are rarely reported. However, we observed a case...
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Endoscopic Clip Closure of Duodenal Perforation Caused by Percutaneous Drainage Procedure

Han DH, Hwang JH, Lee SH, Lee TM, Pyeon SI, Lee DW, Shin JG, Oh KJ

Acute cholecystitis is a disease commonly treated in health care institutions. Cholecystectomy is the standard treatment for acute cholecystitis, and emergent laparoscopic cholecystectomy is acceptable as an effective and safe...
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Perforation of Gastrointestinal Stromal Tumor in Small Bowel on an Elderly Patient Presenting Acute Abdominal Pain

Oh KJ, Hwang JH, Lee HY, Pyeon SI, Shin JG, Park HJ, Chae CB

Acute abdominal pain as a common complaint in elderly patients may differ from that in younger patients. In elderly patients, the diagnostic accuracy of acute abdominal pain is lower compared...
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Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

Lim YJ, Cha EY, Jung HE, Ghim JL, Lee SJ, Kim EY, Shin JG

The Vietnamese-Koreans, especially offspring between a Vietnamese mother and a Korean father constituted the highest proportion (64.2%) of total Kosian population according to a census in 2014. To evaluate genetic...
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