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Adjuvant therapy using ex vivo-expanded allogenic natural killer cells in hepatectomy patients with hepatitis B virus related solitary hepatocellular carcinoma: MG4101 study

Kim JM, Cho SY, Rhu J, Jung M, Her JH, Lim O, Choi GS, Shin EC, Hwang YK, Joh JW

Backgrounds/Aims: Fewer reports have been published regarding hepatectomy patients with solitary hepatocellular carcinoma (HCC) who received immunotherapeutic agents as adjuvant therapy. We evaluated the safety and efficacy of ex vivo-expanded...
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Roles of Type I and III Interferons in COVID-19

Choi H, Shin EC

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line...
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A Clinical Risk Score to Predict In-hospital Mortality from COVID-19 in South Korea

Her AY, Bhak Y, Jun EJ, Yuan SL, Garg S, Lee S, Bhak J, Shin ES

Background: Early identification of patients with coronavirus disease 2019 (COVID-19) who are at high risk of mortality is of vital importance for appropriate clinical decision making and delivering optimal treatment....
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A Case of Aneurysm Occurring at the Dissection Site after Intervention with Drug-Coated Balloon

Yuan SL, Jun EJ, Kim MH, Garg S, Shin ES

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Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice

Song CH, Kim N, Nam RH, Choi SI, Kang C, Jang JY, Nho H, Shin E, Lee HN

Colon tumors develop more frequently in male than in female. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays differential roles in the stage of tumorigenesis. The purpose of this study...
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Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: a Pandora Box to Explain Prognostic Differences

Kim HK, Tantry US, Park HW, Shin ES, Geisler T, Gorog DA, Gurbel PA, Jeong YH

Arterial and venous atherothrombotic events are finely regulated processes involving a complex interplay between vulnerable blood, vulnerable vessel, and blood stasis. Vulnerable blood (‘thrombogenicity’) comprises complex interactions between cellular components...
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SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals

Rha MS, Kim AR, Shin EC

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4 + and CD8 + T-cell...
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Determinants of Healthy Living Practice: County Approach

Jeong CR, Kim JM, Park CY, Shin E, Tchoe B

Background: The purpose of this study is to investigate the factors affecting the healthy living practice rate such as non-smoking, moderate drinking, walking, and low-salt diet by elementary municipality (so...
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The Influence of Disability on Prevalence of Obesity at Each Stage: Considering Severity and Type of Disability

Jeong JY, Koo JH, Shin EC, Lee HJ

Background: This study purposed to examine the difference in the prevalence of obesity at each stage among people with and without disabilities considering the severity and type of disability. Methods: The...
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Effects of Cryopreservation and Thawing on Single-Cell Transcriptomes of Human T Cells

Lee JS, Yi K, Ju YS, Shin EC

Cryopreservation and thawing of PBMCs are inevitable processes in expanding the scale of experiments in human immunology. Here, we carried out a fundamental study to investigate the detailed effects of...
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Adjuvanticity of Processed Aloe vera gel for Influenza Vaccination in Mice

Song EJ, Españo E, Nam JH, Kim J, Shim KS, Shin E, Park YI, Lee CK, Kim JK

The effectiveness of current influenza vaccines is considered suboptimal, and 1 way to improve the vaccines is using adjuvants. However, the current pool of adjuvants used in influenza vaccination is...
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MRI-Based Multimodal Approach to the Assessment of Clinical Symptom Severity of Obsessive-Compulsive Disorder

Park SE, Kim BC, Yang JC, Jeong GW

Objective This study assessed the associations of the abnormal brain activation and functional connectivity (FC) during memory processing and brain volume alteration in conjunction with psychiatric symptom severity in patients...
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The effect of alcohol dose on the development of hypertension in Asian and Western men: systematic review and meta-analysis

Jung MH, Shin ES, Ihm SH, Jung JG, Lee HY, Kim CH

Background/Aims: There are inconsistencies in the effects of low to moderate dose alcohol consumption on the development of hypertension in adult men. We hypothesized that a region-specific effect might participate...
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Baseline Serum Interleukin-6 Levels Predict the Response of Patients with Advanced Non-small Cell Lung Cancer to PD-1/PD-L1 Inhibitors

Kang DH, Park CK, Chung C, Oh IJ, Kim YC, Park D, Kim J, Kwon GC, Kwon I, Sun P, Shin EC, Lee JE

Although various studies on predictive markers in the use of PD-1/PD-L1 inhibitors are in progress, only PD-L1 expression levels in tumor tissues are currently used. In the present study, we...
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Type 1 Diabetes Home Care Project and Educational Consultation

Shin EC

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that absolutely lacks insulin production. It requires lifelong care, including proper diet and exercise, along with insulin administration. It is important...
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Effects of care promotion program based on nursing students self-understanding: Application of enneagram group education

Shin ES, Lee S

Purpose: The purpose of this study was to examine the effects of a care promotion program based on nursing students’ self-understanding. Methods: A quasi-experimental approach using a randomized clinical trial pre-...
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Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression; do they have survival impact to pancreatic cancer?

Hwang DW, Shin E, Cho JY, Han HS, Yoon YS

Backgrounds/Aims: Gemcitabine is still one of adjuvant options in chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC). Integral membrane transporter protein and intracellular enzymes including human equilibrative nucleoside transporter 1 (hENT1),...
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Importance of Pancreatic Duct Stenting and Enteral Feeding in Treatment Algorithm of Pancreatic Fluid Collections

Kim SH, Shin EJ

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KCDC Risk Assessments on the Initial Phase of theCOVID-19 Outbreak in Korea

Kim I, Lee J, Lee J, Shin E, Chu C, Lee SK

Objectives: This study aims to evaluate the risk assessments of coronavirus 2019 (COVID-19) in the Korea Centers for Disease Control and Prevention (KCDC), from the point of detection to the provision...
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Extracorporeal membrane oxygenation for takotsubo cardiomyopathy that developed after mitral valve replacement

Choi JH, Oh ID, Shin E, Lee S, Jeon JM, Kim HT, Youn HC

Takotsubo cardiomyopathy is a transient systolic and diastolic left ventricular dysfunction that presents several wall-motion abnormalities, while the coronary artery shows normal findings. Because patients with Takotsubo cardiomyopathy present with...
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