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The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells

Jung HE, Shim YR, Oh JE, Oh DS, Lee HK

Hematopoietic stem cells (HSCs) in bone marrow are pluripotent cells that can constitute the hematopoiesis system through self-renewal and differentiation into immune cells and red blood cells. To ensure a...
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Caspase-1 Independent Viral Clearance and Adaptive Immunity Against Mucosal Respiratory Syncytial Virus Infection

Shim YR, Lee HK

Respiratory syncytial virus (RSV) infection is recognized by the innate immune system through Toll like receptors (TLRs) and retinoic acid inducible gene I. These pathways lead to the activation of...
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A case of perivascular epithelioid cell tumor (PEComa) arising in the colon

Kim KH, Jang BI, Kim TN, Jang JC, Shim MC, Shim YR, Choi JH

  • KMID: 2256417
  • Korean J Med.
  • 2007 May;72(5):540-545.
Perivascular epithelioid cell tumor (PEComa) is a rare family of related mesenchymal neoplasms that include angiomyolipoma, lymphangiomyomatosis and clear cell 'sugar' tumor of the lung. Although this type of tumor...
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Remission of intestinal Behcet's disease treated with anti-tumor necrosis factor alpha monoclonal antibody (Infliximab)

Lee JH, Kim TN, Choi ST, Jang BI, Shin KC, Lee SB, Shim YR

Behcet's disease (BD) is a chronic relapsing multisystem disease characterized by oral ulceration, genital ulceration and ocular lesions. Gastrointestinal involvement is rare, often difficult to treat and associated with a...
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Detection of Cyclin D1 Protein in Inflammation, Dysplasia and Carcinoma of the Laryngeal Mucosa

Bai CH, Choi YH, Chen SM, Kim YD, Shim YR, Song SY

  • KMID: 2276624
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Apr;49(4):415-419.
BACKGROUND AND OBJECTIVES: Cyclin D1 is one of the proteins regulating G1-S transition in the cell cycle and is considered to play an important role in subsequent mitotic division. So...
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Fine Needle Aspiration Cytology of Alveolar Soft Part Sarcoma: A Case Report

Choi JH, Shim YR, Shin DS, Cho KH

  • KMID: 1931576
  • Korean J Cytopathol.
  • 2006 Mar;17(1):69-74.
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, which occurs predominantly in adolescents and young adults. The cytological characteristics of this condition have been described only rarely...
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Multiple primary lung cancer: Synchronous small cell lung carcinoma and squamous cell carcinoma

Shin KC, Shim YR, Chung JH, Lee KH

  • KMID: 2081143
  • Korean J Med.
  • 2005 Aug;69(2):231-233.
No abstract available.
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Synovial Sarcoma with Massive Myxoid Feature: A Case Report

Choi JH, Shim YR, Bae YK, Kim MJ, Shin DS, Cho KH

  • KMID: 1855951
  • Korean J Pathol.
  • 2005 Aug;39(4):273-277.
Focal myxoid change in synovial sarcoma is not uncommon, although the presence of predominantly myxoid stroma is very rare. Recognition of synovial sarcomas with massive myxoid feature is important because...
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Gene Promoter Hypermethylation in Tumors and Plasma of Breast Cancer Patients

Bae YK, Shim YR, Choi JH, Kim MJ, Gabrielson E, Lee SJ, Hwang TY, Shin SO

  • KMID: 1804577
  • Cancer Res Treat.
  • 2005 Aug;37(4):233-240.
PURPOSE: To measure the hypermethylation of four genes in primary tumors and paired plasma samples to determine the feasibility of gene promoter hypermethylation markers for detecting breast cancer in the...
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Cribriform-Morular Variant of Papillary Thyroid Carcinoma: A Report of Two Cases

Shim YR, Bae YK, Choi JH, Kim MJ, Choi WH

  • KMID: 2275441
  • Korean J Pathol.
  • 2005 Feb;39(1):48-53.
Cribriform-morular variant of papillary thyroid carcinoma is an unusual and peculiar subtype of papillary thyroid carcinomas. It occurs both sporadically and in association with familial adenomatous polyposis. We report here...
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Imprint Cytologic Features of Epithelioid Sarcoma: A Case Report

Shim YR, Choi JH

  • KMID: 2144049
  • Korean J Cytopathol.
  • 2004 May;15(1):65-69.
Epithelioid sarcoma is a malignant soft tissue neoplasm with an uncertain histogenesis. We report the imprint cytologic features of epithelioid sarcoma in the left shoulder of a 29-year-old male patient....
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A Case of Coexistent Lichen Sclerosus et Atrophicus and Morphea

Park JW, Kim WJ, Jeong KB, Shin DH, Choi JS, Kim KH, Shim YR

Cases of coexistent lichen sclerosus et artrophicus and morphea have been reported. It is controversial that both diseases are single disease-spectrum or entirely separated. We encounterd a forty five year...
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Correlation Between Expression of p53, Bcl-2 Protein and Ki-67 Labelling Index and Lymph Node Metastasis in Early Gastric Cancer

Choi JH, Shim YR

  • KMID: 2275574
  • Korean J Pathol.
  • 2002 Feb;36(1):7-12.
BACKGROUND: The purpose of this study was to investigate the difference of cliniopathological variables and p53, bcl-2, and Ki-67 labelling index between early gastric cancer with and without lymph node...
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Choroid Plexus Carcinoma: A Report of Two Cases

Shim YR, Gu MJ, Kim DS, Kim OL, Byun WM, Kim YJ

  • KMID: 2275651
  • Korean J Pathol.
  • 2001 Apr;35(2):176-179.
Choroid plexus carcinoma (CPC), a frankly malignant epithelial neoplasm derived from choroid plexus epithelium, is a rare tumor with a predilection for infants and children. It may be difficult to...
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Two Cases of Advanced Ovarian Serous Tumor of Borderline Malignancy

Jung WY, Jung KM, Han DG, Lee YG, Park YG, Lee DJ, Lee SH, Kim MJ, Shim YR

  • KMID: 1572608
  • Korean J Gynecol Oncol Colposc.
  • 2001 Dec;12(4):353-358.
Ovarian serous tumors of low malignant potential (borderline serous tumors) are intermediate in their clinical behavior between benign serous cystadenoma and malignant neoplasm, and are associated with 10 year survival...
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Clinical Characteristics and Abnormal p53 Expression of Lung Cancer Associated with Multiple Primary Cancer

Shin CJ, Park HJ, Shin KC, Shim YR, Chung JH, Lee KH

  • KMID: 2318213
  • Tuberc Respir Dis.
  • 1999 Sep;47(3):331-338.
BACKGROUND: Nearly 10% of cancer patients will develop a second primary cancer within ten years after surgical removal of the primary tumor. The detection of risk factors for developing multiple...
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Carcinoma Showing Thymus-Like Differentiation (CASTLE) of the Thyroid Gland: A case report

Gu MJ, Shim YR, Choi JH, Choi WH

  • KMID: 2011654
  • Korean J Pathol.
  • 1999 Jun;33(6):460-462.
Carcinoma Showing Thymus-Like Differentiation (CASTLE) is a rare tumor, which occurs in the thyroid gland and surrounding soft tissue, or soft tissue of the neck. It is thought to originate...
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DNA Sequencing of p53 Gene Mutation in Colorectal Carcinomas

Shim YR, Choi JH, Choi WH

  • KMID: 2011648
  • Korean J Pathol.
  • 1999 Jun;33(6):422-433.
Mutations in the p53 gene occur during the development of colorectal carcinomas, and play an important role in the conversion of adenoma into carcinoma. To detect the p53 gene mutation...
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Comprison of p53 Mutation in Non Small Cell Lung Cancer between Young patients and Old Patients

Shin KC, Lee KH, Shim YR

BACKGROUND: Lung cancer in younger patients seems to be a more aggressive disease and their prognosis may be worse than that of older patients. Abnormal p53 expression in primary lung...
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Expression of MIB-1 in Endometrial Adenocarcinoma: Correlation with p53 Protein Expression and Histologic Prognostic Factors

Kim MJ, Shim YR, Kim DS

  • KMID: 2141039
  • Korean J Pathol.
  • 1999 Dec;33(12):1146-1151.
The evaluation of the proliferative potential of malignant neoplasm is of major interest for predicting their biological behavior. MIB-1, a monoclonal antibody against the Ki-67 antigen, is a marker of...
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