- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
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Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
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- Validation of the Korean Version of the Depression in Old Age Scale and Comparison with Other Depression Screening Questionnaires Used in Elderly Patients in Medical Settings
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Jung YE, Kim MD, Bahk WM, Woo YS, Nam B, Seo JS, Jang SH, Sung HM, Shim IH, Yoon BH, Kim JS, Kwon YJ
- KMID: 2457400
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):369-376.
- doi: 10.9758/cpn.2019.17.3.369
OBJECTIVE: The Depression in Old Age Scale (DIA-S) is a new screening tool for assessing depression in the elderly. The primary aims of this study were to describe the validation... -
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- Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
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Lee B, Shim I, Lee H, Hahm DH
- KMID: 2419002
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):525-538.
- doi: 10.4196/kjpp.2018.22.5.525
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported... -
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- Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder
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Lee B, Shim I, Lee H, Hahm DH
- KMID: 2410108
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):183-192.
- doi: 10.4196/kjpp.2018.22.2.183
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear... -
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- Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review
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Shim IH, Bahk WM, Woo YS, Yoon BH
- KMID: 2428966
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):376-382.
- doi: 10.9758/cpn.2018.16.4.376
We reviewed clinical studies investigating the pharmacological treatment of major depressive episodes (MDEs) with mixed features diagnosed according to the dimensional criteria (more than two or three [hypo]manic symptoms+principle depressive... -
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- Predictors of a Shorter Time to Hospitalization in Patients with Bipolar Disorder: Medication during the Acute and Maintenance Phases and Other Clinical Factors
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Shim IH, Woo YS, Wang HR, Bahk WM
- KMID: 2388271
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):248-255.
- doi: 10.9758/cpn.2017.15.3.248
OBJECTIVE: The present study was conducted to compare the effects of pharmacological treatments during the acute and maintenance phases of mood episodes, sociodemographic, and clinical characteristics between a shorter time... -
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- Sedative Effect of Sophora flavescens and Matrine
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Lee HJ, Lee SY, Jang D, Chung SY, Shim I
- KMID: 2386905
- Biomol Ther.
- 2017 Jul;25(4):390-395.
- doi: 10.4062/biomolther.2016.156
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The... -
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- An Empirical Study on Factor Associated with Mood Disorders in Elderly: Focusing on the Influence of Community Characteristics
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Chang M, Shim IS
- KMID: 2388034
- Health Policy Manag.
- 2017 Jun;27(2):177-185.
- doi: 10.4332/KJHPA.2017.27.2.177
BACKGROUND: The mental problems of the elderly are at issue as a serious social phenomenon. The purpose of this study is to identify risk factors affecting the mood disorders of... -
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- Clonal Expansion of Allergen-specific CD4⺠T Cell in the Lung in the Absence of Lymph Nodes
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Choi G, Kim BS, Park YJ, Shim I, Chung Y
- KMID: 2383354
- Immune Netw.
- 2017 Jun;17(3):163-170.
- doi: 10.4110/in.2017.17.3.163
The expansion of allergen-specific CD4⺠T cells is a critical step in inducing airway inflammation during allergic asthma. Such clonal expansion of T cells is initiated through the interaction between... -
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- Dose Trends of Aripiprazole from 2004 to 2014 in Psychiatric Inpatients in Korea
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Woo YS, Shim IH, Lee SY, Lee DB, Kim MD, Jung YE, Lee J, Won S, Jon DI, Bahk WM
- KMID: 2378487
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):177-180.
- doi: 10.9758/cpn.2017.15.2.177
OBJECTIVE: Although aripiprazole has been widely used to treat various psychiatric disorders, little is known about the adequate dosage for Asian patients in clinical practice. Hence, we evaluated the initial... -
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- Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
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Lee KJ, Shim I, Sung JH, Hong JT, Kim IS, Cho CB
- KMID: 2374874
- J Korean Neurosurg Soc.
- 2017 Feb;60(2):138-145.
- doi: 10.3340/jkns.2016.0202.020
OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson’s disease. However, the neurochemical basis of its effects remains unknown. The... -
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- The significance of blood pressure variation and metabolic risk factors in patients with different stages of hypertension
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Kim SM, Shim IK, Lee JW, Lee JY, Lee SW, Cho KI, Kim HS, Lee JW, Heo JH
- KMID: 2400261
- Kosin Med J.
- 2017 Dec;32(2):179-190.
- doi: 10.7180/kmj.2017.32.2.179
OBJECTIVES: Blood pressure variation (BPV) and metabolic syndrome is an independent risk factor for cardiovascular events. Ambulatory blood Pressure (ABP) has been shown to be more closely related to cardiovascular... -
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- Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder
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Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2371053
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):357-366.
- doi: 10.4196/kjpp.2016.20.4.357
Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of... -
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- Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice
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Ye M, Chung HS, Lee C, Song JH, Shim I, Kim YS, Bae H
- KMID: 2361531
- Exp Mol Med.
- 2016 Jul;48(7):e244.
- doi: 10.1038/emm.2016.49
α-Synuclein (α-Syn) has a critical role in microglia-mediated neuroinflammation, which leads to the development of Parkinson's disease (PD). Recent studies have shown that bee venom (BV) has beneficial effects on... -
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- Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats
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Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2164226
- Biomol Ther.
- 2016 May;24(3):328-337.
- doi: 10.4062/biomolther.2015.152
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these... -
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- Effect of Methylene Blue-mediated Photodynamic Therapy on Wild-type and Ciprofloxacin-resistant Mycobacterium smegmatis
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Shim I, Choi M, Min Y, Seok KH, Kim JK, Jeong JY, Oak CH, Park I
- KMID: 2168740
- J Bacteriol Virol.
- 2016 Mar;46(1):27-35.
- doi: 10.4167/jbv.2016.46.1.27
Tuberculosis (TB) patients are normally treated with a combination of antibiotics. However, with improper or incomplete treatment of antibiotics, the disease may progress to multidrug-resistant TB (MDR-TB). The treatment of... -
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- Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms
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Joung HY, Kang YM, Lee BJ, Chung SY, Kim KS, Shim I
- KMID: 2380298
- Biomol Ther.
- 2015 Sep;23(5):479-485.
- doi: 10.4062/biomolther.2014.122
This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis... -
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- Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration
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Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2380309
- Biomol Ther.
- 2015 Nov;23(6):571-581.
- doi: 10.4062/biomolther.2015.027
beta-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and... -
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- Erratum to "L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats" [Biomol. Ther. 22 (2014) 213-222]
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Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2380327
- Biomol Ther.
- 2014 Sep;22(5):474-474.
- doi: 10.4062/biomolther.2014.474
In the article, incorrect images were placed in Fig. 8. -
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- A Trend of Medication Prescription Pattern for Outpatients with Bipolar Disorder in a University Hospital: Focusing on Atypical Antipsychotics
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Lee SM, Shim IH, Woo YS, Jun TY, Bahk WM
- KMID: 2287775
- Korean J Psychopharmacol.
- 2014 Jul;25(3):124-133.
OBJECTIVE: Atypical antipsychotics and newly developed anticonvulsants have become increasingly popular medication for bipolar disorder. Especially, atypical antipsychotics have increasing importance in treatment of bipolar disorder and a number of... -
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