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[18F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment

Jeong HJ, Lee H, Lee SY, Seo S, Park KH, Lee YB, Shin DJ, Kang JM, Yeon BK, Kang SG, Cho J, Seong JK, Okamura N, Villemagne VL, Na DL, Noh Y

Background and Purpose Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography...
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A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model

Kim YJ, Kim HJ, Lee WJ, Seong JK

Aerobic exercise is well known to have a positive impact on body composition, muscle strength, and oxidative capacity. In animal model, both treadmill and wheel running exercise modalities have become...
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Evaluation of factors related to Anaesthesia-induced Lens opacity in experimental mice

Lee H, Kim HK, Shin HS, Han SJ, Yoon S, Seong JK, Seo KY

To investigate conditions that cause temporal lens opacity, we tested chemical and physical factors, such as anaesthesia dose, ocular surface dryness, and infrared (IR) light exposure in anaesthetised C57BL/6 N mice....
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Effect of a Single Bout of Exercise on Autophagy Regulation in Skeletal Muscle of High-Fat High-Sucrose Diet-Fed Mice

Zhang D, Lee JH, Kwak SE, Shin HE, Zhang Y, Moon HY, Shin DM, Seong JK, Tang L, Song W

BACKGROUND: Autophagy maintains metabolic homeostasis of muscles, and its impairment may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long-term high-fat diet. This study aimed to explore the...
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Welcome to Laboratory Animal Research

Seong JK

No abstract available.
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TarGo: network based target gene selection system for human disease related mouse models

Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK

Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are...
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Efficacy and Safety of UI05MSP015CT in Functional Dyspepsia: A Randomized, Controlled Trial

Yoon H, Lee DH, Lee YH, Jeong JC, Lee ST, Choi MG, Jeon SW, Shim KN, Baik GH, Kim JG, Moon JS, Sung IK, Lee SK, Rhee PL, Jung HY, Lee BE, Kim HS, Kim SG, Lee KM, Seong JK, Jang JS, Park JJ

BACKGROUND/AIMS: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). METHODS: Patients with FD were randomly assigned (1:1) to...
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Ensuring reproducibility and ethics in animal experiments reporting in Korea using the ARRIVE guideline

Nam MH, Chun MS, Seong JK, Kim HG

The aim of this study is to evaluate the reporting quality of animal experiments in Korea using the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guideline developed in 2010...
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Machine learning in biomedical engineering

Park C, Took CC, Seong JK

No abstract available.
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Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes

Nam SM, Kwon HJ, Kim W, Kim JW, Hahn KR, Jung HY, Kim DW, Yoo DY, Seong JK, Hwang IK, Yoon YS

In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in...
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Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

Nam SM, Kim JW, Yoo DY, Kim W, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or...
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Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes

Nam SM, Kim JW, Yoo DY, Jung HY, Choi JH, Hwang IK, Seong JK, Yoon YS

In this study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old...
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Postnatal changes in glucose transporter 3 expression in the dentate gyrus of the C57BL/6 mouse model

Jung HY, Yim HS, Yoo DY, Kim JW, Chung JY, Seong JK, Yoon YS, Kim DW, Hwang IK

In this study, we observed the ontogenetic changes in glucose transporter 3 (GLUT3) immunoreactivity, a major neuronal GLUT, in the dentate gyrus of mouse brains at various ages: postnatal day...
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A Case of Endoscopically Complete Remission of Esophageal Neuroendocrine Tumors by Concurrent Chemoradiation Therapy

Kim MH, Jeong HY, Seong JK, Moon HS, Kang SH, Kim DK

Neuroendocrine tumors (NETs) of the esophagus are extremely rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, radiotherapy and/or surgery appear effective. Here, we present a patient with...
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Air assisted lamellar keratectomy for the corneal haze model

Kim S, Park YW, Lee E, Park SW, Park S, Kim JW, Seong JK, Seo K

To standardize the corneal haze model in the resection depth and size for efficient corneal haze development, air assisted lamellar keratectomy was performed. The ex vivo porcine corneas were categorized...
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Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus

Nam SM, Kim JW, Yoo DY, Choi JH, Kim W, Jung HY, Won MH, Hwang IK, Seong JK, Yoon YS

Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor...
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Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats

Kim JW, Chae J, Nam SM, Kim YN, Yoo DY, Choi JH, Jung HY, Song W, Hwang IK, Seong JK, Yoon YS

In the present study, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean...
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Nephrotic Syndrome Related to Early Gastric Cancer

Kim GD, Kim HJ, Shin HJ, Joo JS, Kim JS, Moon HS, Kang SH, Seong JK, Jeong HY, Song KS

Nephrotic syndrome results in a prolonged, heavy increase in glomerular permeability to proteins. Nephrotic syndrome caused by malignant neoplasms accounts for 7.9% to 10.9%. Nephrotic syndrome can improve following resection...
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Helicobacter apodemus sp. nov., a new Helicobacter species identified from the gastrointestinal tract of striped field mice in Korea

Jeon WJ, Dong HJ, Shin JH, Kim IY, Ho H, Oh SH, Yoon YM, Choi YK, Suh JG, Nam KH, Kim HC, Cho S, Seong JK

A novel Helicobacter species was identified from the gastrointestinal tract of the Korean striped field mouse (Apodemus agrarius). Biochemical testing, ultrastructure characterization, and 16S rRNA gene sequence analysis suggested that...
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The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats

Kim JY, Choi MJ, So B, Kim HJ, Seong JK, Song W

BACKGROUND: We investigated the therapeutic effects of resistance training on Zucker rats before and after the onset of diabetes to understand the importance of the timing of exercise intervention. We...
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