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Emergence of Monosomy 7 in Philadelphia-Negative Cells during MDS Development and not CML Diagnosis Proved by Serial Droplet Digital PCR

Park S, Mun YC, Seong CM, Huh J

Emergence of new clonal chromosomal abnormality (CCA) has been reported in Philadelphia-negative cells in patients with chronic myeloid leukemia (CML) undergoing the tyrosine kinase inhibitor (TKI) treatment. However, the time...
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GATA1 Expression in BCR/ABL1-negative Myeloproliferative Neoplasms

Yang N, Park S, Cho MS, Lee M, Hong KS, Mun YC, Seong CM, Huh HJ, Huh J

BACKGROUND: This study aimed to determine GATA1 expression levels to better characterize subgroups in BCR/ABL1-negative myeloproliferative neoplasms (MPNs). METHODS: This study enrolled 49 patients diagnosed as having BCR/ABL1-negative MPN on the...
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Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis

Park S, Mun YC, Seong CM, Huh HJ, Huh J

BACKGROUND: Natural killer (NK) cells play a key role in innate immune responses and are an important component of anti-cancer defenses. This study aimed to investigate the clinicopathological characteristics of...
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Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma

Yang N, Mun YC, Seong CM, Huh HJ, Huh J

In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM...
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Neutrophilic Leukemoid Reaction Associated with Malignancy Initially Suspected as Chronic Neutrophilic Leukemia

So MK, Park S, Mun YC, Seong CM, Huh HJ, Huh J

Although neutrophilia can manifest from various causes, it is important to be able to distinguish chronic neutrophilic leukemia (CNL) from neutrophilic leukemoid reactions (NLR). In this paper, we describe four...
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Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements

Huh J, Mun YC, Yoo ES, Seong CM, Chung WS

Translocations leading to fusions between the immunoglobulin heavy chain gene (IGH) and various partner genes have been reported in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, submicroscopic deletions within IGH...
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Chromothripsis Identified by Copy Number Profiling in a Case of Plasma Cell Leukaemia

Sohn MJ, Mun YC, Seong CM, Chung WS, Huh J

  • KMID: 2200447
  • J Lab Med Qual Assur.
  • 2014 Jun;36(2):107-112.
A genomic instability called chromothripsis occurs as a single catastrophic event, generating massive complex genomic rearrangement with a possible characteristic pattern of copy number oscillations. Here, we report a case...
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Ring Chromosome 5 in Acute Myeloid Leukemia Defined by Whole-genome Single Nucleotide Polymorphism Array

Huh J, Mun YC, Chung WS, Seong CM

Chromosomes forming a corresponding ring cannot be clearly defined by conventional cytogenetics or FISH. Karyotypic analyses using whole-genome single nucleotide polymorphism arrays (SNP-A) may result in the identification of previously...
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Sole Trisomy 22 Not Associated with inv(16) in Myelodysplastic Syndrome

Hahm C, Hwang Y, Mun YC, Seong CM, Chung WS, Huh J

Trisomy 22 is closely associated with inv(16) or t(16;16) and could be a marker of cryptic rearrangement of CBFB/MYH11 in acute myeloid leukemia (AML). Trisomy 22 not associated with CBFB/MYH11...
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An unrelated Clone of 20q Deletion Following Successful Treatment of Leukemia in Patients with t(8;21), t(15;17) or t(9;22)

Hahm C, Mun YC, Seong CM, Chung WS, Huh J

  • KMID: 1426765
  • J Lab Med Qual Assur.
  • 2012 Dec;34(2):107-111.
Cases of clonal cytogenetic abnormalities in Philadelphia-negative cells during the treatment of Philadelphia-positive CML have been previously reported. However, clonal abnormalities unrelated to the original t(8;21) or t(15;17) karyotype are...
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Additional Genomic Aberrations Identified by Single Nucleotide Polymorphism Array-Based Karyotyping in an Acute Myeloid Leukemia Case with Isolated del(20q) Abnormality

Hahm C, Mun YC, Seong CM, Chung WS, Huh J

  • KMID: 2434489
  • Ann Lab Med.
  • 2012 Nov;32(6):445-449.
Prognosis is known to be better in cases with isolated chromosomal abnormalities than in those with complex karyotypes. Accordingly, del(20q) as an isolated abnormality must be distinguished from cases in...
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An Adrenocorticotropic Hormone-secreting Malignant Pancreatic Neuroendocrine Tumor

Song EM, Lee KE, Jo JY, Koo HS, Choi MY, Seong CM, Lee SN

  • KMID: 1966889
  • Korean J Med.
  • 2011 Feb;80(2):238-242.
Pancreatic endocrine tumors are low-to-intermediate-grade neoplasms arising from the pancreatic islets that produce various hormones. These tumors account for a minority of pancreatic tumors and are generally considered functional if...
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Clinical utility of FISH analysis in addition to G-banded karyotype in hematologic malignancies and proposal of a practical approach

Kwon WK, Lee JY, Mun YC, Seong CM, Chung WS, Huh J

BACKGROUND: Fluorescence in situ hybridization (FISH) analysis can provide important information in the management of patients with hematologic malignancies. However, FISH performed in addition to G-banded karyotype can be labor-intensive...
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Guillain-Barre Syndrome After Peripheral Blood Stem Cell Transplantation

Kim JY, Jeong EH, Choi MY, Seong CM, Park KD

  • KMID: 2184981
  • J Korean Neurol Assoc.
  • 2010 Aug;28(3):206-208.
Neuromuscular complications after hematopoietic stem cell transplantation are rarely reported. We report one male patient with ophthalmoplegia, flaccid paralysis, and hyporeflexia after peripheral blood stem cell transplantation (PBSCT). A cerebrospinal...
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Myelodysplastic Syndrome Mimicking Idiopathic Thrombocytopenic Purpura

Hwang Y, Huh JW, Mun YC, Seong CM, Chung WS

BACKGROUND: In patients with isolated thrombocytopenia, but without significant dysplasia, diagnosis of idiopathic thrombocytopenic purpura (ITP) rather than myelodysplastic syndrome (MDS) may be taken into account. It is important to...
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Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH

Kim MK, Mun YC, Seong CM, Chung WS, Huh J

A variant Philadelphia chromosome (Ph) is generated from translocation of one or more partner chromosomes in addition to chromosomes 9 and 22. We have described the cases of 2 patients...
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A Case of Wernicke's Encephalopathy Following Fluorouracil-based Chemotherapy

Cho IJ, Chang HJ, Lee KE, Won HS, Choi MY, Nam EM, Mun YC, Lee SN, Seong CM

The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal...
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Acute Fibrinous and Organizing Pneumonia Following Hematopoietic Stem Cell Transplantation

Lee SM, Park JJ, Sung SH, Kim Y, Lee KE, Mun YC, Lee SN, Seong CM

A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed...
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Effects of Transmigration of Bone Marrow Nuclear Cells Through Endothelial Cell and Stromal Cell by Leukotriene B4 and Inhibition of Reactive Oxygen Species

Mun YC, Oh SA, Lee KE, Yoo ES, Choi MY, Ahn JY, Seong CM

OBJECTIVES: Leukotriene B4(LTB4) is lipid mediator derived from membrane phospholipids during the process of inflammation, having many roles(ie; inducer of chemotaxis, the production of nitric oxide, transepithelial migration of neutrophil)....
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High-dose Versus Low-dose Cyclophosphamide in Combination with G-CSF for Peripheral Blood Progenitor Cell Mobilization

Ahn JS, Park S, Im SA, Yoon SS, Lee JS, Kim BK, Bang SM, Cho EK, Lee JH, Jung CW, Kim HC, Seong CM, Lee MH, Kim CS, Lee KS, Lee JA, Ahn MJ

BACKGROUND: To compare the mobilizing effects and toxicities of two different doses of cyclophosphamide (CY) plus lenograstim (glycosylated G-CSF), we performed a prospective randomized study by enrolling patients suffering with...
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