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Langerhans cell histiocytosis of the mandible: two case reports and literature review

Hwang DS, Lee JS, Kim UK, Park HR, Ryu MH, Lee JH, Jung YH, Kim GC

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of dendritic cells resulting in local or systemic symptoms. The clinical symptoms of patients with Langerhans cell histiocytosis...
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Misdiagnosis of ameloblastoma in a patient with clear cell odontogenic carcinoma: a case report

Park JC, Kim SW, Baek YJ, Lee HG, Ryu MH, Hwang DS, Kim UK

Clear cell odontogenic carcinoma (CCOC), a rare tumor in the head and neck region, displays comparable properties with other tumors clinically and pathologically. In consequence, an incorrect diagnosis may be...
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Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands

Bazarsad S, Kim JY, Zhang X, Kim KY, Lee DY, Ryu MH, Kim J

PURPOSE: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiple recurrences and late distant metastasis. Biological markers for assessing the prognosis of...
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A Prospective Randomized Comparison of a Covered Metallic Ureteral Stent and a Double-J Stent for Malignant Ureteral Obstruction

Kim JW, Hong B, Shin JH, Park J, Kim JH, Gwon DI, Ryu MH, Ryoo BY

OBJECTIVE: To compare the safety and efficacy between a covered metallic ureteral stent (CMS) and a double-J ureteral stent (DJS) for the treatment of a malignant ureteral obstruction (MUO). MATERIALS AND...
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Retrospective clinical study of multiple keratocystic odontogenic tumors in non-syndromic patients

Hwang DS, Kim YH, Kim UK, Ryu MH, Kim GC

OBJECTIVES: A keratocystic odontogenic tumor (KOT) is a type of odontogenic tumor that mainly occurs in the posterior mandible. Most KOTs appear as solitary lesions; however, they sometimes occur as...
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Phase II Study of Induction Chemotherapy with Docetaxel, Capecitabine, and Cisplatin Plus Bevacizumab for Initially Unresectable Gastric Cancer with Invasion of Adjacent Organs or Paraaortic Lymph Node Metastasis

Kim JH, Park SR, Ryu MH, Ryoo BY, Kim KP, Kim BS, Yoo MW, Yook JH, Kim BS, Kim J, Byeon SJ, Kang YK

PURPOSE: The purpose of this study was to evaluate the efficacy and safety of induction chemotherapy with docetaxel, capecitabine, and cisplatin (DXP) plus bevacizumab (BEV) on initially unresectable locally advanced...
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Reconstruction of cheek mucosal defect with a buccal fat pad flap in a squamous cell carcinoma patient: a case report and literature review

Hwang DS, Park J, Kim UK, Park HR, Kim GC, Ryu MH

BACKGROUND: Squamous cell carcinoma (SCC) is the most commonly occurring malignant tumor in the oral cavity. In South Korea, it occurs most frequently in the mandible, tongue, maxilla, buccal mucosa,...
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Efficacy and Safety of Regorafenib in Korean Patients with Advanced Gastrointestinal Stromal Tumor after Failure of Imatinib and Sunitinib: A Multicenter Study Based on the Management Access Program

Son MK, Ryu MH, Park JO, Im SA, Kim TY, Lee SJ, Ryoo BY, Park SR, Kang YK

PURPOSE: The aim of this study was to confirm the efficacy and safety of regorafenib for advanced gastrointestinal stromal tumors (GISTs) reported in the GRID phase III trial in Korean...
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Anti-angiogenic Therapy in Patients with Advanced Gastric and Gastroesophageal Junction Cancer: A Systematic Review

Chen LT, Oh DY, Ryu MH, Yeh KH, Yeo W, Carlesi R, Cheng R, Kim J, Orlando M, Kang YK

Despite advancements in therapy for advanced gastric and gastroesophageal junction cancers, their prognosis remains dismal. Tumor angiogenesis plays a key role in cancer growth and metastasis, and recent studies indicate...
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Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha-Mutated Gastrointestinal Stromal Tumors

Yoo C, Ryu MH, Jo J, Park I, Ryoo BY, Kang YK

PURPOSE: The incidence of gastrointestinal stromal tumors (GISTs) harboring platelet-derived growth factor receptor alpha (PDGFRA) mutations is low, therefore further investigation of the efficacy of imatinib in this subgroup was...
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HER2-Positive Gastric Hepatoid Adenocarcinoma

Kim JK, Shin JH, Lee J, Kwon OC, Park HB, Hwang IH, Ryu MH

Gastric hepatoid adenocarcinoma is a rare adenocarcinoma that develops in the stomach. The prognosis of gastric hepatoid adenocarcinoma is poorer than that of ordinary gastric adenocarcinoma. Here, we report the...
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Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor

Koo DH, Ryu MH, Kim KM, Yang HK, Sawaki A, Hirota S, Zheng J, Zhang B, Tzen CY, Yeh CN, Nishida T, Shen L, Chen LT, Kang YK

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors...
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Severe Imatinib-Associated Skin Rash in Gastrointestinal Stromal Tumor Patients: Management and Clinical Implications

Park SR, Ryu MH, Ryoo BY, Beck MY, Lee IS, Choi MJ, Lee MW, Kang YK

PURPOSE: This study evaluated the incidence of imatinib-associated skin rash, the interventional outcomes of severe rash, and impact of severe rash on the outcomes of imatinib treatment in gastrointestinal stromal...
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A Case of Clear-Cell Sarcoma in the Stomach

Kim JH, Kim BS, Song JS, Cho H, Kim J, Lee J, Ryu MH

Clear-cell sarcoma (CCS) is a rare soft tissue sarcoma that usually develops in the lower extremities of young adults. CCS of the gastrointestinal tract is extremely rare. We report here...
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Significant Symptom Relief with Hepatic Artery Embolization in a VIPoma with Liver Metastases

Choi YS, Ko GY, Ryu MH, Khang SK, Kim JE, Song JS, Kang YK

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) cause VIPoma syndrome, which is characterized by watery diarrhea, hypokalemia, and achlorhydria. The treatment options for metastatic VIPomas include somatostatin analogs, cytoreductive surgery, and chemotherapy....
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A Case of Complete Remission of Mucosa-associated Lymphoid Tissue Lymphoma of the Urinary Bladder after Eradication of Helicobacter Pylori

Lee S, Choo MS, Ryu MH, Song M, Seo S, Jeong Y, Seo M, Huh J

Primary lymphoma of the urinary bladder is rare, comprising 0.2% of extranodal lymphomas. The predominant subtype of mucosa-associated lymphoid tissue (MALT) is extranodal marginal zone lymphoma. We report a case...
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Consideration of Facelift Methods and Facial Retaining Ligaments in Asians

Ryu MH

BACKGROUND: The demand for facelifts is rapidly increasing in Asia because of economic development as well as the aging of the population. It is difficult to obtain satisfactory results, because...
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A Neuromedin B Receptor Blockade Inhibits the Growth of Human Oral Cancer Cells

Park HJ, Jeon JH, Kim MK, Ryu MH, Kim YD, Bae SK, Bae MK

  • KMID: 1703485
  • Int J Oral Biol.
  • 2014 Mar;39(1):1-7.
Neuromedin B (NMB) acts as a growth factor or a morphogen and plays a role in cancer progression. Indeed, the NMB receptor (NMB-R) is overexpressed in different types of tumors....
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Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients

Yoon S, Ryu MH, Yoo C, Beck MY, Ryoo BY, Kang YK

Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib...
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Adjuvant Chemotherapy in Gastric Cancer

Ryu MH, Zang DY

  • KMID: 2263447
  • Korean J Med.
  • 2012 Sep;83(3):291-296.
Gastric cancer remains the second most common malignancy worldwide. Surgical resection with D2 lymph node dissection is the standard of care in localized gastric cancer. However about 40% of patients...
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