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Genomic Surveillance of SARS-CoV-2: Distribution of Clades in the Republic of Korea in 2020

Park AK, Kim IH, Kim J, Kim JM, Kim HM, Lee Cy, Han MG, Rhie GE, Kwon D, Nam JG, Park YJ, Gwack J, Lee NJ, Woo S, No JS, Lee J, Ha J, Rhee J, Yoo CK, Kim EJ

Since a novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019, there has been a rapid global spread of the virus. Genomic surveillance was...
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2019 Tabletop Exercise for Laboratory Diagnosis and Analyses of Unknown Disease Outbreaks by the Korea Centers for Disease Control and Prevention

Kim IH, Jang JH, Jo SK, No JS, Seo SH, Kim JY, Jung SO, Kim JM, Lee SE, Park HK, Kim EJ, Jeon JH, Choi MM, Ryu By, Jang YS, Kim Hm, Lee J, Shin SH, Kim HK, Kim EK, Park YE, Yoo CK, Lee SW, Han MG, Rhie GE, Kang BH

Objectives: The Korea Centers for Disease Control and Prevention has published “A Guideline for Unknown Disease Outbreaks (UDO).” The aim of this report was to introduce tabletop exercises (TTX) to...
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Current status of vaccine development for tularemia preparedness

Hong KJ, Park PG, Seo SH, Rhie GE, Hwang KJ

  • KMID: 2391973
  • Clin Exp Vaccine Res.
  • 2013 Jan;2(1):34-39.
Tularemia is a high-risk infectious disease caused by Gram-negative bacterium Francisella tularensis. Due to its high fatality at very low colony-forming units (less than 10), F. tularensis is considered as...
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GFP-tagged E. coli shows bacterial distribution in mouse organs: pathogen tracking using fluorescence signal

Park PG, Cho MH, Rhie GE, Jeong H, Youn H, Hong KJ

PURPOSE: In vaccine efficacy evaluation, visualization of pathogens in whole organism at each time point would be able to reduce the consuming animals and provide the in vivo information within...
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The Laboratory Diagnosis of Melioidosis in a Korean Patient

Shin YW, Cho MH, Chun JH, Kim C, Oh HB, Rhie GE, Yoo CK

Burkholderia pseudomallei is a gram-negative opportunistic intracellular pathogen that causes an acute and fatal septicemic melioidosis in humans. The organism is mainly found in Southeastern Asia and Northern Australia. Recently,...
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Detection of Botulinum Neurotoxin Type A by In Vitro Bioassay Based on Endopeptidase Activity

Kim YJ, Baek JH, Kim JH, Kim BS, Rhie GE, Yoo CK, Shin NR

Botulinum neurotoxin type A (BoNT/A) is a metalloprotease that cleaves SNAP-25 (synaptosome-associated protein of 25 kDa), a specific cellular protein essential for neurotransmitter release. As well as mouse bioassay to...
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Development of Capture ELISA Using a Biotinylated Monoclonal Antibody for Detection of Botulinum Neurotoxin Type A

Kim YJ, Shin NR, Kim JH, Yoon SY, Rhie GE, Kim BS, Oh HB

A capture enzyme-linked immunosorbent assay (capture ELISA) was developed to detect Clostridium botulinum neurotoxin type A (BoNT/A) in assay buffer and human serum. The assay is based upon affinity-purified rabbit...
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