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Total Hip Arthroplasty: Past, Present, and Future. What Has Been Achieved?

Shon WY, Park BY, R RN, Park PS, Im JT, Yun HH

In the 1960s, Sir John Charnley introduced to clinical practice his concept of low-friction total hip arthroplasty (THA). Although early designs were plagued by poor performance and even failure, there...
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ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages

Shrestha A, Pun NT, Park PH

Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying...
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YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages

Oh HJ, Magar TB, Pun NT, Lee Y, Kim EH, Lee ES, Park PH

Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated...
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p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells

Shrestha M, Park PH

Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized...
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Usefulness of intraoperative bronchoscopy during surgical repair of a congenital cardiac anomaly with possible airway obstruction: three cases report

Oh J, Kim JW, Shin WJ, Gwak M, Park PH

Compression of the airway is relatively common in pediatric patients, although it is often an unrecognized complication of congenital cardiac and aortic arch anomalies. Aortopexy has been established as a...
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Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats

Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC

Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the...
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Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling

Kim MJ, Kadayat T, Um YJ, Jeong TC, Lee ES, Park PH

Chalcones (1,3-diaryl-2-propen-1-ones), a subfamily of flavonoid, are widely known to possess potent anti-inflammatory and anti-oxidant properties. In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone...
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The factors associated with longitudinal changes in liver stiffness in patients with chronic hepatitis B

Yo IK, Kwon OS, Park JW, Lee JJ, Lee JH, Won IS, Na SY, Jang PK, Park PH, Choi DJ, Kim YS, Kim JH

BACKGROUND/AIMS: Liver stiffness (LS) as assessed by transient elastography (TE) can change longitudinally in patients with chronic hepatitis B (CHB). The aim of this study was to identify the factors...
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TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1

Kim MJ, Kadayat T, Kim DE, Lee ES, Park PH

Chalcones (1,3-diaryl-2-propen-1-ones), a flavonoid subfamily, are widely known for their anti-inflammatory properties. Propenone moiety in chalcones is known to play an important role in generating biological responses by chalcones. In...
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Regulatory Role of Autophagy in Globular Adiponectin-Induced Apoptosis in Cancer Cells

Nepal S, Park PH

Adiponectin, an adipokine predominantly secreted from adipose tissue, exhibits diverse biological responses, including metabolism of glucose and lipid, and apoptosis in cancer cells. Recently, adiponectin has been shown to modulate...
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A Case of Gastric Ulcer Bleeding by Direct Connection to the Splenic Artery

Jang PK, Kim YJ, Park DK, Han JY, Park PH, Kim SH, Woo HS, Kim JH

Gastric ulcer bleeding is commonly encountered in emergency situations for gastroenterologist. Usually depth of gastric ulcer does not exceed the muscle layer. We report a case of a 67-year-old male...
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A Case of Epidermoid Cyst in the Intrapancreatic Accessory Spleen Mimicking Pancreas Mucinous Cystic Neoplasm

Park PH, Cho JH, Jang PK, Han JY, Lee SI, Kim YS

  • KMID: 2448452
  • Korean J Pancreas Biliary Tract.
  • 2014 Jul;19(3):142-146.
An epidermoid cyst arising from intrapancreatic accessory spleen (ECIPAS) is a rare disease. Most patients with an ECIPAS are detected incidentally and could be misdiagnosed as a pancreatic cystic neoplasm...
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Cardiac arrest following reversal of muscle relaxation by pyridostigmine: A case report

Jo JY, Yi JM, Lee YK, Ku SW, Park PH

  • KMID: 1908529
  • Anesth Pain Med.
  • 2014 Jul;9(3):205-208.
The anticholinesterase pyridostigmine is usually used as a reversal agent of non-depolarizing muscle relaxants in general anesthesia. Most adverse muscarinic effects of anticholinesterases are controlled by anticholinergics; however, there is...
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Clinical Features of Non-alcoholic Fatty Liver Disease in Cryptogenic Hepatocellular Carcinoma

Rim MY, Kwon OS, Ha M, Kim JS, Ko KI, Kim DK, Jang PK, Han JY, Park PH, Jung YK, Choi DJ, Kim YS, Kim JH

BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic...
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Cardiovascular collapse due to right heart failure following ethanol sclerotherapy: a case report

Jo JY, Chin JH, Park PH, Ku SW

Ethanol sclerotherapy for the treatment of low-flow vascular malformations can cause catastrophic cardiopulmonary complications, including pulmonary embolism and pulmonary hypertension, that can result in right heart failure and fatal arrhythmias,...
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A Comparison Study of Ballooning Time between Immediate and Conventional Deflation Method of Endoscopic Papillary Large Balloon Dilation for the Extraction of Difficult Bile Duct Stone

Lee SI, Jang SJ, Han SY, Park PH, Lee YH, Jang PK, Kim JH, Cho JH, Kim YS

BACKGROUND/AIMS: The ballooning time in endoscopic papillary large balloon dilation (EPLBD) remains controversial. The aim of this study was to evaluate the significance of the ballooning time comparing an immediate...
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Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187

Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW

  • KMID: 2170660
  • Biomol Ther.
  • 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the...
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Sedation and general anesthesia outside of the operating room

Choi YJ, Kim MH, Song CS, Kim SH, Hong JY, Suk EH, Kil SH, Bae HY, Kim DH, Park PH

  • KMID: 2046840
  • Anesth Pain Med.
  • 2012 Jul;7(3):230-235.
BACKGROUND: The aim of this study is to evaluate the status and adverse events of anesthesiologist-administered sedation and general anesthesia, outside of the operating room. METHODS: Patients undergoing sedation and general...
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Clinical Experiences of Transforaminal Balloon Decompression for Patients with Spinal Stenosis

Kim SH, Koh WU, Park SJ, Choi WJ, Suh JH, Leem JG, Park PH, Shin JW

Lumbar spinal stenosis is a commonly treated with epidural injections of local anesthetics and corticosteroids, however, these therapies may relieve leg pain for weeks to months but do not influence...
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Reticulocyte Indices for the Differential Diagnosis of Anemia of Chronic Disease and Iron Deficiency Anemia in Adult Women with Microcytic Hypochromic Anemia

Park SH, Seo YH, Park PH, Kim KH, Song YH, Jung JH, Ahn JY

  • KMID: 2312181
  • Lab Med Online.
  • 2011 Jul;1(3):147-152.
BACKGROUND: Iron deficiency anemia (IDA) is the most common anemia followed by anemia of chronic disease (ACD). Reticulocyte indices have been shown to be helpful indicators for detecting IDA. We...
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