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Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid

Kang MG, Lee HS, Tantisira , Park HW

Purpose: Acute exacerbation (AE) is an important domain of asthma management and may be related with ineffective response to corticosteroid. This study aimed to find mechanisms of AE using genome-wide...
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Orbital Apex Syndrome Caused by Co-infection of Actinomyces with Invasive Fungal Sinusitis

Yoon JS, Hong SR, Park HW

Purpose: We report a case of orbital apex syndrome caused by co-infection of Actinomyces and Aspergillus invasive fungal sinusitis. Case summary: An 87-year-old female visited our clinic for decreased visual acuity...
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Dynamic Change of Ischemic Mitral Regurgitation in a Patient with Acute Coronary Syndrome

Kim HR, Kang MG, Kim K, Park HW, Hwang JY, Park JR

Ischemic mitral regurgitation (IMR) is commonly known as a chronic complication of left ventricular remodeling due to coronary artery disease. Acute IMR after coronary artery disease, such as acute myocardial...
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Clinical Results of Surgical Treatment with Minimally Invasive Percutaneous Plate Osteosynthesis for Displaced Intra-articular Fractures of Calcaneus

Suh JW, Yang JH, Park HW

Purpose: This study evaluated the clinical results of surgical treatment with minimally invasive plate osteosynthesis for treating displaced intra-articular fractures of the calcaneus in comparison with conventional lateral extensile approach...
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Factors for Survival and Complications of Malignant Bone Tumor Patients with a Total Femoral Replacement

Cho WH, Jeon DG, Song WS, Park HS, Nam HS, Kim KH

Purpose: Total femoral replacement (TFR) is an extreme form of limb salvage. Considering the rarity of this procedure, reports have focused on the complications and a proper indication is unclear....
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Defining Association between COVID-19 and the Multisystem Inflammatory Syndrome in Children through the Pandemic

Kim YJ, Park H, Choi YY, Kim YK, Yoon Y, Kim KR, Choi EH

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Risk Factors for Acute Exacerbations in Elderly Asthma: What Makes Asthma in Older Adults Distinctive?

Sohn KH, Song WJ, Park JS, Park HW, Kim TB, Park CS, Cho SH, on behalf of the Elderly Asthma Cohort in Korea Group

PURPOSE: Asthma in the elderly (EA; ≥ 65 years of age) is increasing, adding a heavy socioeconomic burden to the healthcare system. However, little is known about risk factors associated...
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Understanding the Molecular Mechanisms of Asthma through Transcriptomics

Park HW, Weiss ST

The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk...
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Sestrin2 Mediates IL-4-induced IgE Class Switching by Enhancing Germline ε Transcription in B Cells

Shim YS, Lee S, Park HW, Park SR

Sestrin2 (Sesn2), a metabolic regulator, accumulates in response to a diverse array of cellular stresses. Sesn2 regulates cellular metabolism by inhibiting the mammalian target of rapamycin complex 1 through the...
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Current Anticoagulant Usage Patterns and Determinants in Korean Patients with Nonvalvular Atrial Fibrillation

Ha HS, Kim J, Lee YS, Kim TH, Lee JM, Park J, Park JK, Kang KW, Shim J, Uhm JS, Park HW, Cha MJ, Choi EK, Kim J, Kim JB, Kim C, Joung B

PURPOSE: Stroke prevention in patients with atrial fibrillation (AF) is influenced by many factors. Using a contemporary registry, we evaluated variables associated with the use of warfarin or direct oral...
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Impact of Anticoagulation Intensity in Korean Patients with Atrial Fibrillation: Is It Different from Western Population?

Lee KH, Cho JG, Lee N, Cho KH, Jeong HK, Park H, Kim Y, Cho JY, Kim MC, Sim DS, Yoon HJ, Yoon N, Kim KH, Hong YJ, Park HW, Ahn Y, Jeong MH, Park JC

BACKGROUND AND OBJECTIVES: Although anticoagulation with warfarin is recommended as an international normalized ratio (INR) of prothrombin time between 2.0 and 3.0 and mean time in the therapeutic range (TTR)...
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Tracheal Stenosis Successfully Treated without Surgery in Preterm Infant

Chung YE, Lee R, Son JS, Park HW

Congenital tracheal stenosis is a rare disease that can be life threatening, especially when early identi fication is missed. A premature twin showed progressive respiratory symptoms at birth and tracheal...
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Distal Fibular Rotational Plasty for Chronic Peroneal Tendon Recurrent Dislocation: A Technical Report

Suh JW, Park HW

Chronic recurrent peroneal dislocation often responds poorly to conservative treatment. Surgical treatment has been reported to be more effective than conservative treatment, and various surgical treatment methods are available: superior...
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Stepwise School Opening and an Impact on the Epidemiology of COVID-19 in the Children

Yoon Y, Kim KR, Park H, Kim S, Kim YJ

Background: Data on severe acute respiratory syndrome coronavirus-2 transmission from a pediatric index patient to others at the school setting are limited. Epidemiological data on pediatric coronavirus disease 2019 (COVID-19)...
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A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF)

Kim H, Lee YS, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Kang KW, Shim J, Uhm JS, Park HW, Choi EK, Kim JB, Kim C, Kim J, Joung B

Background/Aims: Efforts to reduce stroke in patients with atrial fibrillation (AF) have focused on increasing physician adherence to oral anticoagulant (OAC) guidelines; however, the high early discontinuation rate of vitamin...
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Effect of Renal Denervation on Suppression of PVC and QT Prolongation in a Porcine Model of Acute Myocardial Infarction

Kim SS, Kim HK, Park HW, Jeong MH, Lim KS, Kee HJ, Ryu YH, Kim HB, Na JY, Ki YJ, Park KH, Choi DH, Lee KH, Yoon NS, Cho JG

BACKGROUND AND OBJECTIVES: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular...
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Identification of MicroRNA Related to the CD34+ Cell Fraction of Cord Blood Stem Cells

Lee JH, Song EY, Kim N, Roh EY, Park HW, Yoon JH, Shin S

BACKGROUND: Cord blood (CB) is a reliable source of hematopoietic stem cells, and its utilization in stem cell transplantation is increasing continuously. The CD34+ cell count is arguably one of...
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A case of FLNA gene mutation with respiratory insufficiency and periventricular heterotopia

Park H, Park MS, Ki CS, Cho J, Lee J, Kim J, Ahn K

Filamin A is an actin-binding protein and, in humans, is encoded by FLNA gene in the long arm of X chromosome. Filamin A plays a role in the formation of...
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Effects of reversing the coiling direction on the force-deflection characteristics of nickel-titanium closed-coil springs

Park HH, Jung SH, Yoon J, Jee KK, Han JH, Baek SH

OBJECTIVE: To investigate the effects of reversing the coiling direction of nickeltitanium closed-coil springs (NiTi-CCSs) on the force-deflection characteristics. METHODS: The samples consisted of two commercially available conventional NiTi-CCS groups and...
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Pattern of Extraocular Muscle Involvements in Miller Fisher Syndrome

Ryu WY, Kim YH, Yoon BA, Park HT, Bae JS, Kim JK

BACKGROUND AND PURPOSE: The most-common initial manifestation of Miller Fisher syndrome (MFS) is diplopia due to acute ophthalmoplegia. However, few studies have focused on ocular motility findings in MFS. This...
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