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Standardization Status of Total Cholesterol Concentration Measurement: Analysis of Korean External Quality Assessment Data

Yoon YA, Lee YW, Kim S, Lee K, Park HD, Chun S, Min WK

Background: Total cholesterol concentration measurement is important in the diagnosis of dyslipidemia and evaluation of cardiovascular disease risk factors. Measurement reliability for obtaining an accurate total cholesterol concentration requires procedure...
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Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories

Kim HK, Park HD, Lee SG, Chae H, Song SH, Lee YW, Yun YM, Ahn S, Kim S, Lee SM, Lee SY, Chun S, on behalf of the Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

Background: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is increasingly used for immunosuppressive drug tests. However, most LC-MS/MS tests are laboratory-developed and their agreement is unknown in different Korean...
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Schemes and Performance Evaluation Criteria of Korean Association of External Quality Assessment (KEQAS) for Improving Laboratory Testing

Kim S, Lee K, Park HD, Lee YW, Chun S, Min WK

External quality assessment (EQA) is important for evaluating clinical laboratories and enhancing their testing quality. EQA schemes are variable; thus, it is crucial that the EQA organizers share their experiences...
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Comparison of Three Blood Collection Tubes for 35 Biochemical Analytes: The Becton Dickinson Barricor Tube, Serum Separating Tube, and Plasma Separating Tube

Shin S, Oh J, Park HD

The Barricor tube (Becton Dickinson [BD], Sunnyvale, CA, USA) was recently developed to mechanically separate plasma by increasing the centrifugation rate. We compared the Barricor tube with existing serum- and...
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Performance Evaluation of Serum IgD Quantification by the SPAPLUS Turbidimetric Analyzer and Determination of a Reference Interval of IgD in the Korean Population

Cho EH, Park HK, Park HD

Background: IgD is an immunoglobulin isotype that accounts for 100 mg/L. The established upper limit of the reference interval was 53.6 mg/L. Conclusions: The SPAPLUS shows good analytical performance for serum...
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Recommendations for Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part III. Quality Assurance

Kim S, Lee SG, Moon SY, Park HD, Song SH, Lee K, Choi HJ, Lee SY, Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

The use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) in clinical laboratories is increasing and is likely to expand into even more clinical venues in the future. Mass spectrometry is the...
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Comparison of Mac-2 Binding Protein Glycosylation Isomer, Fibroscan, and Other Fibrosis Markers for Assessing Liver Cirrhosis in Patients with Chronic Hepatitis B Virus-mediated Hepatocellular Carcinoma

Lee K, Yoo IY, Joh JW, Kim JM, Gwak GY, Sinn DH, Ha SY, Kang ES, Park HD

Background Liver cirrhosis is advanced stage of hepatic brosis caused by viral hepatitis. Mac-2 binding protein glycosylation isomer (M2BPGi) is a serum marker to diagnose and evaluate hepatic brosis progression. In...
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Recommendations for Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part II. Method Validation

Moon SY, Choi HJ, Kim S, Lee K, Lee SG, Song SH, Lee SY, Park HD, Clinical Mass Spectrometry Research Committee of theKorean Society of Clinical Chemistry

The demand for obtaining test results using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for accurate diagnosis in the field of laboratory medicine is expected to increase, but it is still not...
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Therapeutic Drug Level Monitoring of Teicoplanin in Korean Pediatric Patients with Normal versus Impaired Renal Function

Choi Js, Kim JM, Kim D, Kim SH, Cho H, Park HD, Lee SY, Kang CI, Kim YJ

Background: Teicoplanin is used to treat serious gram-positive infections. Optimal teicoplanin trough levels are considered to be ≥ 10 μg/mL. Despite its wide use in various clinical settings, data on...
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Vancomycin and Aminoglycoside Antibiotic Drug Concentration Measurement: Current Status in Clinical Laboratories in Korea

Kwon WK, Oh J, Lee SY, Park HD

Background: Therapeutic drug monitoring (TDM) is clinically recommended for vancomycin and aminoglycoside antibiotics owing to their narrow therapeutic range and nephrotoxicity at high concentrations in the blood. This study was...
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Comparison of Serum Creatinine Measurements among Roche Modular D, Cobas 8000 c702, and Beckman Coulter AU5800, by Jaffe and Enzymatic Methods

Oh J, Park HD

BACKGROUND: Creatinine (Cr) is a representative biomarker reflecting renal function. In this study, we compared serum Cr levels using Roche Modular D (Roche Diagnostics, Germany), Roche Cobas 8000 c702 (Roche...
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Performance Evaluation and Clinical Usefulness of α-fetoprotein Test Measured on Sysmex HISCL-5000

Jung J, Kang ES, Park HD

BACKGROUND: Serum α-fetoprotein (AFP) test is useful for the diagnosis of hepatocellular carcinoma (HCC) and monitoring its recurrence after treatment. In Korea, patients with a higher risk of HCC are...
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Recommendations for the Use of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory: Part I. Implementation and Management

Lee K, Moon SY, Kim S, Choi HJ, Lee SG, Park HD, Lee SY, Song SH, Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

Many types of assays involving mass spectrometry have been developed and applied in clinics. However, mass spectrometry has not been widely implemented yet relative to other measurement methods, including biochemical...
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Temporal Trends of Cardiac Implantable Electronic Device Implantations: a Nationwide Population-based Study

Lee JH, Lee SR, Choi EK, Jeong J, Park HD, You SJ, Lee SS, Oh S

BACKGROUND AND OBJECTIVES: Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several...
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Use of Liquid Chromatography-Tandem Mass Spectrometry for Clinical Testing in Korean Laboratories: a Questionnaire Survey

Chae H, Cho SE, Park HD, Chun S, Lee YW, Yun YM, Song SH, Lee SG, Lee K, Song J, Lee SY, On behalf of the Clinical Mass Spectrometry Research Committee of Korean Society of Clinical Chemistry

BACKGROUND: The use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has substantially increased in clinical laboratories worldwide. To assess the status of clinical LC-MS/MS testing in Korean laboratories, a questionnaire survey...
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The Burden and Risk Factors for Infection of Transvenous Cardiovascular Implantable Electronic Device: a Nationwide Cohort Study

Yang PS, Jeong J, You SJ, Yu HT, Kim TH, Sung JH, Lee SS, Park HD, Joung B

BACKGROUND AND OBJECTIVES: There are limited published data on the incidence and cost associated with cardiac implantable electrical device (CIED) infection for Asian patients. We analyzed the infection burden associated...
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A Questionnaire Survey on General Status and Opinions about Clinical Mass Spectrometric Analysis in Korea (2018)

Cho SE, Chae H, Park HD, Chun S, Lee YW, Yun YM, Song SH, Lee SG, Lee K, Song J, Lee SY, On behalf of the Clinical Mass Spectrometry Research Committee of Korean Society of Clinical Chemistry

The Clinical Mass Spectrometry Research Committee (CMSRC), in affiliation with the Korean Society of Clinical Chemistry (KSCC), conducted a questionnaire survey on opinions about the general status of clinical mass...
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Analyses of the Proficiency Testing Program and the Performance of Qualitative Reagents for Rheumatoid Factor

Oh J, Park HD

BACKGROUND: Rheumatoid factor (RF) is used as one of the diagnostic criteria for rheumatoid arthritis. The purpose of this study was to evaluate qualitative RF reagents used in clinical laboratories...
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Clinical and molecular characterization of Korean children with infantile and late-onset Pompe disease: 10 years of experience with enzyme replacement therapy at a single center

Kim MS, Song A, Im M, Huh J, Kang IS, Song J, Yang A, Kim J, Kwon EK, Choi EJ, Han SJ, Park HD, Cho SY, Jin DK

PURPOSE: Pompe disease (PD) is an autosomal recessive disorder caused by a deficiency of acid alpha-glucosidase resulting from pathogenic GAA variants. This study describes the clinical features, genotypes, changes before...
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Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation

Bae JY, Kim DY, Kwon YD, Song YH, Lim HH, Park HD, Lim JW

Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH...
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