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Genetic Analysis of Korean Adult Patients with Nontuberculous Mycobacteria Suspected of Primary Ciliary Dyskinesia Using Whole Exome Sequencing

Cho EH, Ki CS, Yun SA, Kim SY, Jhun BW, Koh WJ, Huh HJ, Lee NY

Purpose: Nontuberculous mycobacteria (NTM) is ubiquitous in the environment, but NTM lung disease (NTM-LD) is uncommon. Since exposure to NTM is inevitable, patients who develop NTM-LD are likely to have...
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A Case of Parotid Tuberculosis Mimicking Benign Tumor of Parotid Gland

Bae GH, Kim JS, Noh WJ

Tuberculosis of parotid gland is extremely rare, even in countries where tuberculosis is endemic. It can occur by systemic dissemination from a distant focus or as primary involvement. Because of...
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Effects of 17β-Estradiol on the Plasminogen Activator System in Vascular Smooth Muscle Cells Treated with Lysophophatidylcholine

Yoon BK, Kang YH, Oh WJ, Lee DY, Kim DK, Kessel B, Kang CD

Objectives: When administered soon after menopause, hormone therapy can prevent coronary heart diseases in women. To explore the mechanism underlying the cardioprotective actions of estrogen, we investigated the effects of...
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17β-Estradiol Inhibits Lysophosphatidylcholine-Induced Apoptosis in Cultured Vascular Smooth Muscle Cells

Yoon BK, Kang YH, Oh WJ, Roh CR, Kim DK, Kang CD

Objectives: Coronary heart disease (CHD) risk increases in women after menopause, but menopausal hormone therapy (MHT) helps prevent CHD if started early after menopause. To explore the mechanism underlying the...
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Diagnostic Performance of the GENEDIA MTB/NTM Detection Kit for Detecting Mycobacterium tuberculosis and Nontuberculous Mycobacteria With Sputum Specimens

Shin S, Yoo IY, Shim HJ, Kang OK, Jhun BW, Koh WJ, Huh HJ, Lee NY

The GENEDIA MTB/NTM Detection Kit (GENEDIA MTB/NTM; Green Cross Medical Science Corp., Chungbuk, Korea) is a multiplex real-time PCR assay used for differential identification of Mycobacterium tuberculosis complex (MTBC) and...
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Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory

Yoo KS, Lee K, Lee YS, Oh WJ, Kim HK

  • KMID: 2508470
  • Exp Neurobiol.
  • 2020 Oct;29(5):334-343.
  • doi: 10.5607/en20049
Guanine nucleotide exchange factors (GEFs) play multiple functional roles in neurons. In a previous study, we reported that Arhgef4 (Rho guanine nucleotide exchange factor 4) functioned as a negative regulator...
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Nontuberculous mycobacterial pulmonary disease in a 16-year-old female patient with bronchiectasis

Song Ys, Jeong Hi, Lee Br, Huh Hj, Koh Wj, Kim Jh, Ahn Km, Kyung Yc

Nontuberculous mycobacterial (NTM) pulmonary disease generally occurs in old people with underlying lung disease. However, unlike adults, NTM infections in children with normal immunity are rare, and they occasionally manifest...
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Treatment of Isoniazid-Resistant Pulmonary Tuberculosis

Jhun BW, Koh WJ

Tuberculosis (TB) remains a threat to public health and is the leading cause of death globally. Isoniazid (INH) is an important first-line agent for the treatment of TB considering its...
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Treatment of Mycobacterium Abscessus Pulmonary Disease

Jhun BW, Koh WJ

Mycobacterium abscessus is the second most important pathogen in pulmonary disease caused by nontuberculous mycobacteria (NTM), following Mycobacterium avium. Mycobacterium abscessus is classified into three subspecies: M. abscessus subsp. abscessus,...
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Mycobacterium shimoidei Pulmonary Disease: The First Case in Korea

Shin S, Yoo IY, Jhun BW, Koh WJ, Ki CS, Lee NY, Huh HJ

Mycobacterium shimoidei is a nontuberculous mycobacterium (NTM), and is rarely reported as a pathogen causing the NTM pulmonary disease. We describe here the case of a 52-year-old male with symptoms...
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Efficacy and local irritation evaluation of Eriobotrya japonica leaf ethanol extract

Seong NW, Oh WJ, Kim IS, Kim SJ, Seo JE, Park CE, Kim DY, Ko JW, Kim JC

BACKGROUND: Although Eriobotrya japonica leaves have been studied as a raw material for various cosmetic products, little is known about the anti-oxidant, anti-inflammatory, and anti-melanogenic activities of Eriobotrya japonica leaf...
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Effect of High-Intensity Focused Ultrasound on Eyebrow Lifting in Asians

Oh WJ, Kwon HJ, Choi SY, Yoo KH, Park KY, Kim BJ

No abstract available.
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First Isolation of Mycobacterium virginiense From a Human Pulmonary Specimen

Jung J, Yoo IY, Jhun BW, Koh WJ, Lee NY, Huh HJ

No abstract available.
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Treatment of Mycobacterium avium Complex Pulmonary Disease

Kwon YS, Koh WJ, Daley CL

The pathogen Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial pulmonary disease worldwide. The decision to initiate long-term antibiotic treatment is difficult for the physician due...
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Diagnosis of pulmonary tuberculosis

Jhun BW, Huh HJ, Koh WJ

The incidence and prevalence of pulmonary tuberculosis (TB) in South Korea remain high despite the fact that South Korea is a high-income country, and pulmonary TB is an important public...
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Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism

Loh WJ, Lim DS, Loh LM, Kek PC

BACKGROUND: The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our...
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Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

Ko RE, Moon SM, Ahn S, Jhun BW, Jeon K, Kwon OJ, Huh HJ, Ki CS, Lee NY, Koh WJ

This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number...
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Bronchiectasis and Recurrent Respiratory Infections with a De Novo STAT1 Gain-of-Function Variant: First Case in Korea

Huh HJ, Jhun BW, Choi SR, Kim YJ, Yun SA, Nham E, Kong T, Ki CS, Koh WJ

Bronchiectasis is a chronic disease characterized by airway infection and inflammation, leading to permanent dilation of the bronchi. Evaluation of underlying etiology is important in managing young bronchiectasis patients with...
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Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease

Kim SY, Koh WJ, Park HY, Jeon K, Lee SY, Yim JJ, Shin SJ

BACKGROUND: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous...
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Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

Choi R, Jeong BH, Koh WJ, Lee SY

Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the...
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