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The Discovery of Clinically Applicable Biomarkers for Bipolar Disorder: A Review of Candidate and Proteomic Approaches

Muneer A

Bipolar disorder (BD) is a severe psychiatric condition which affects innumerable people across the globe. The etiopathogenesis of BD is multi-faceted with genetic, environmental and psychosocial factors playing a role....
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Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations

Muneer A

Under physiological conditions 95% of the ingested essential amino acid tryptophan is metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme nicotinamide adenine dinucleotide, fulfilling cellular energy requirements....
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Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Muneer A, Minhas FA

Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric...
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Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders

Muneer A, Shamsher Khan RM

The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding...
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The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates

Muneer A, Mazommil R

OBJECTIVE: Staging of psychiatric disorders is gaining momentum and the purpose of this review is to examine whether major mood disorders can be defined according to stages. METHODS: In April 2018...
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Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications

Muneer A

The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial...
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Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment

Muneer A

Many bipolar disorder patients exhibit mixed affective states, which portend a generally more severe illness course and treatment resistance. In the previous renditions of Diagnostic and Statistical Manual mixed states...
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Pharmacotherapy of Acute Bipolar Depression in Adults: An Evidence Based Approach

Muneer A

In the majority of cases of bipolar disorder, manic episodes are usually brief and typically responsive to currently available psychopharmacological agents. In contrast, depressive manifestations are more prevalent and persistent,...
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Staging Models in Bipolar Disorder: A Systematic Review of the Literature

Muneer A

Bipolar disorder is manifested as severe dysregulation of mood with recurrent manic and major depressive episodes. It is associated with psychiatric and medical comorbidities, inadequate response to currently available pharmacological...
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Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers

Muneer A

Bipolar disorder is a severe and enduring psychiatric condition which in many cases starts during early adulthood and follows a relapsing and remitting course throughout life. In many patients the...
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The Neurobiology of Bipolar Disorder: An Integrated Approach

Muneer A

Bipolar disorder is a heterogeneous condition with myriad clinical manifestations and many comorbidities leading to severe disabilities in the biopsychosocial realm. The objective of this review article was to underline...
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Pharmacotherapy of Bipolar Disorder with Quetiapine: A Recent Literature Review and an Update

Muneer A

Bipolar disorder is a chronic, recurrent condition with the usual onset during adolescence or early adulthood. In the Diagnostic and Statistical Manual of Mental Disorders 5th edition, it is conceptualized...
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Aripiprazole in the Treatment of Refractory Mood Disorders: A Case Series

Muneer A

  • KMID: 2279948
  • Clin Psychopharmacol Neurosci.
  • 2014 Aug;12(2):157-159.
Major depressive disorder and bipolar disorders are among the commonest neuropsychiatric conditions, affecting persons of both sexes which belong to all age groups. Comorbidity is the rule rather than the...
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