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Assessment of Hand Motor Function in a Non-human Primate Model of Ischemic Stroke

Won J, Yi KS, Choi CH, Jeon CY, Seo J, Kim K, Yeo HG, Park J, Kim YG, Jin YB, Koo BS, Lim KS, Lee S, Kim KJ, Choi WS, Park SH, Kim YH, Huh JW, Lee SR, Cha SH, Lee Y

  • KMID: 2506534
  • Exp Neurobiol.
  • 2020 Aug;29(4):300-313.
  • doi: 10.5607/en20023
Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. A non-human primate (NHP) model of ischemic stroke was previously developed to investigate its pathophysiology and for efficacy...
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Cancer patients with neutropenic septic shock: etiology and antimicrobial resistance

Jung SM, Kim YJ, Ryoo SM, Sohn CH, Seo DW, Lim KS, Kim WY

Background/Aims: Among patients with febrile neutropenia that developed after chemotherapy, high-risk patients, such as those having clinical instability or Multinational Association of Supportive Care in Cancer score of < 21,...
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Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease

Seo Jc, Won Jy, Kim Kw, Park Jh, Yeo HG, Kim YG, Baek SH, Lee H, Jeon CY, Choi WS, Lee S, Kim KJ, Park SH, Son Yh, Jeong KJ, Lim KS, Kang P, Lee HY, Son HC, Huh JW, Kim YH, Lee DS, Lee SR, Choi JW, Lee Yj

  • KMID: 2508474
  • Exp Neurobiol.
  • 2020 Oct;29(5):376-388.
  • doi: 10.5607/en20040
ymptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an...
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Effect of Renal Denervation on Suppression of PVC and QT Prolongation in a Porcine Model of Acute Myocardial Infarction

Kim SS, Kim HK, Park HW, Jeong MH, Lim KS, Kee HJ, Ryu YH, Kim HB, Na JY, Ki YJ, Park KH, Choi DH, Lee KH, Yoon NS, Cho JG

BACKGROUND AND OBJECTIVES: Antiarrhythmic effect of renal denervation (RDN) after acute myocardial infarction (AMI) remains unclear. The goal of this study was to evaluate the effect of RDN on ventricular...
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Increased CD68/TGFβ Co-expressing Microglia/Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys

Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR

The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in...
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Novel porcine model of acute myocardial infarction using polyethylene terephthalate

Kim YS, Kim NY, Bae IH, Park JK, Park DS, Shim JW, Kang WS, Kim HB, Song BS, Koo BS, Jeong KJ, Kim SU, Kim HK, Kim SS, Kim MC, Sim DS, Hong YJ, Ahn Y, Lim KS, Jeong MH

Acute myocardial infarction (AMI) is considered the major cause of mortality in the world. Tremendous animal studies are performed to develop novel therapeutics, and this study aimed to induce porcine...
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Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling

Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y

Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is...
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Evaluation of fecal microbiomes associated with obesity in captive cynomolgus monkeys (Macaca fascicularis)

Koo BS, Hwang EH, Kim G, Oh H, Son Y, Lee D, Lim KS, Kang P, Lee S, Lee HY, Jeong KJ, Lee Y, Baek SH, Jeon CY, Park SJ, Kim YH, Huh JW, Jin YB, Kim SU, Lee SR, Hong JJ

Microorganisms play important roles in obesity; however, the role of the gut microbiomes in obesity is controversial because of the inconsistent findings. This study investigated the gut microbiome communities in...
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Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction

Kim HK, Kim HB, Lee JM, Kim SS, Bae IH, Park DS, Park JK, Shim JW, Na JY, Lee MY, Kim JS, Sim DS, Hong YJ, Nam CW, Doh JH, Park J, Koo BK, Kim SU, Lim KS, Jeong MH

BACKGROUND: Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events....
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Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model

Jeong KJ, Kang P, Lee HY, Son HC, Park SH, Choi WS, Koo BS, Jeon CY, Baek SH, An YJ, Kim HK, Kim SS, Park JK, Bae IH, Park DS, Shim JW, Kim JU, Kim NY, Kim SU, Lim KS, Jeong MH

This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary...
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APACHE II Score Immediately after Cardiac Arrest as a Predictor of Good Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Receiving Targeted Temperature Management

Kim SI, Kim YJ, Lee YJ, Ryoo SM, Sohn CH, Seo DW, Lee YS, Lee JH, Lim KS, Kim WY

BACKGROUND: This study assessed the association between the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score and good neurological outcome in comatose survivors of out-of-hospital cardiac arrest who...
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Retrospective study of single vitrified-warmed blastocyst transfer cycles according to the presence of morphokinetic variables

Hur YS, Ryu EK, Hyun CS, Yang SH, Yoon SH, Lim KS, Lee WD, Lim JH

This study retrospectively assessed whether time-lapse data relating to developmental timing and morphology were associated with clinical outcomes, with the eventual goal of using morphokinetic variables to select embryos prospectively...
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Rapid Collection of Opinions from Healthcare Professionals in Multiple Institutions Using Short Message Service and Google Forms

Lee W, Shin SY, Seo DW, Sohn CH, Ryu JM, Lee JH, Kim WY, Oh BJ, Hong SO, Lim KS

No abstract available.
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Intravenous immunoglobulin G in women with reproductive failure: The Korean Society for Reproductive Immunology practice guidelines

Sung N, Han AR, Park CW, Park DW, Park JC, Kim NY, Lim KS, Shin JE, Joo CW, Lee SE, Kim JW, Lee SK, IVIG Task Force, Korean Society for Reproductive Immunology

The task force of the Korean Society for Reproductive Immunology recommends intravenous immunoglobulin G treatment in women with reproductive failure, including recurrent pregnancy loss and/or repeated implantation failure, who show...
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Characteristics of orbital wall fractures in preschool and school-aged children

Yang DJ, Kim YJ, Seo DW, Lee HJ, Park IJ, Sohn CH, Ryoo JM, Lee JS, Kim WY, Lim KS

OBJECTIVE: This study aimed to evaluate the injury patterns in pediatric patients with an orbital wall fracture (OWF) and to identify the differences in injury patterns between preschool and school-aged...
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Post lumbar puncture headache: Case report of a serious adverse event in first-in-human study

Shin W, Kim MK, Kim J, Woo MH, Cho DY, Lim KS

A lumbar puncture can be used to measure the concentrations of drugs and/or pharmacodynamic biomarkers during clinical trials of central nervous system drugs. We report a case of a post...
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Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea

Kim MC, Kim YS, Kang WS, Lee KH, Cho M, Hong MH, Lim KS, Jeong MH, Ahn Y

Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA®...
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The Control of Drug Release and Vascular Endothelialization after Hyaluronic Acid-Coated Paclitaxel Multi-Layer Coating Stent Implantation in Porcine Coronary Restenosis Model

Bae IH, Jeong MH, Kim JH, Park YH, Lim KS, Park DS, Shim JW, Kim JH, Ahn Y, Hong YJ, Sim DS

BACKGROUND AND OBJECTIVES: Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not...
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Effect of Stents Coated with Artemisinin or Dihydroartemisinin in a Porcine Coronary Restenosis Model

Jang S, Jeong MH, Lim KS, Bae IH, Park JK, Park DS, Shim JW, Kim JH, Kim HK, Sim DS, Hong YJ, Ahn Y, Kang JC

BACKGROUND AND OBJECTIVES: Artemisinin and dihydroartemisinin are drugs used to treat malaria. These drugs suppress inflammatory reactions. The aim of this study was to examine the anti-intima hyperplasia effect of...
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Comparison of static culture, micro-vibration culture, and micro-vibration culture with co-culture in poor ovarian responders

Hur YS, Ryu EK, Yoon SH, Lim KS, Lee WD, Lim JH

OBJECTIVE: This study was conducted to compare the effects of static culture, dynamic culture, and the combination of dynamic culture with specialized surfaces involving co-culture on human embryonic development. Embryos...
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