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Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice

Leem YH, Yoon SS, Jo SA

Previous studies have shown disrupted synaptic plasticity and neural activity in depression. Such alteration is strongly associated with disrupted synaptic structures. Chronic stress has been known to induce changes in...
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Cdo Is Required for Efficient Motor Neuron Generation of Embryonic Stem Cells

Kim H, Lee SY, Jeong HJ, Kang JS, Cho H, Leem YE

Background and Objectives: The directed differentiation of pluripotent stem cells into motor neurons is critical for the development of disease modelling and therapeutics to intervene degenerative motor neuron diseases. Cell...
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Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways

Park JS, Leem YH, Park JE, Kim DY, Kim HS

Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a...
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Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression

Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S

Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been...
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Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Seo JS, Choi J, Leem YH, Han PL

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within...
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The Effects of Extracellular pH on Proliferation and Differentiation of human Bone Marrow Stem Cells

Leem YH, Nam TS, Kim JH, Lee KS, Lee DH, Yun J, Chang JS

OBJECTIVES: The purpose of this study is to identify whether the change of pH affects the proliferation and the differentiation of human bone marrow stem cells (hBMSCs) and what mechanism...
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Central Pain from Excitotoxic Spinal Cord Injury Induced by Intraspinal NMDA Injection: A Pilot Study

Leem YJ, Joh JW, Joeng KW, Suh JH, Shin JW, Leem JG

BACKGROUND: The pathophysiological and neurochemical changes following spinal injury are not yet elucidated. This study was designed to evaluate the morphological changes of the dorsal horn of the spinal cord...
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The Effect of Thoracic Epidural Lidocaine on Blood Flow of Grafted Coronary Vessels in Coranary Artery Bypass Graft Surgery

Sim J, Leem Y, Kim D, Ko W, Choi I

BACKGROUND: Thoracic epidural anesthesia (TEA) is increasingly used to reduce stress response, pain and pulmonary complication of patients under coronary artery bypass graft (CABG). However, effects of TEA on blood...
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