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Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial

Cho YK, Choi MG, Park H, Kim JW, Lee DH, Ko KH, Kim SG, Jung HY, Hong SJ, Lee YC, Lee SH

  • KMID: 2514680
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):223-230.
  • doi: 10.5056/jnm19053
Background/Aims S-isomer (S) pantoprazole is more bioavailable and less dependent on cytochrome 2C19 than is racemic pantoprazole. We aim to evaluate the efficacy and safety of 10 mg S-pantoprazole for treatment...
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A Systematic Review and Meta-analysis of Randomized Control Trials: Combination Treatment With Proton Pump Inhibitor Plus Prokinetic for Gastroesophageal Reflux Disease

Jung DH, Huh CW, Lee SK, Park JC, Shin SK, Lee YC

  • KMID: 2514673
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):165-175.
  • doi: 10.5056/jnm20161
Background/Aims Prokinetics can be used for treating patients with gastroesophageal reflux disease (GERD), who exhibit suboptimal response to proton pump inhibitor (PPI) treatment. We conducted a systematic review to assess the...
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Evidence-Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea 2020

Jung HK, Kang SJ, Lee YC, Yang HJ, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointestinal Research

Helicobacter pylori infection is one of the most common infectious diseases worldwide. Although the prevalence of H. pylori is gradually decreasing, approximately half of the world's population still becomes infected...
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Clinicopathologic Features of Submucosal Papillary Gastric Cancer Differ from Those of Other Differentiated-Type Histologies

Shin SY, Kim JH, Kook MC, Park DY, Ryu KW, Choi IJ, Noh SH, Kim H, Lee YC

Background/Aims: Papillary gastric cancer (GC) is classified as differentiated adenocarcinoma, together with well-differentiated (WD) and moderately differentiated (MD) adenocarcinoma. This study evaluated the risk of lymph node metastasis (LNM) in...
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Clinical Guidelines for Drug-induced Peptic Ulcer, 2020 Revised Edition

Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter and Upper Gastrointestinal Research

The Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcers were previously developed under co-work with the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology...
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Evaluation of usefulness of smart device-based testing: a survey study of Korean medical students

Lee YC, Kwon OY, Hwang HJ, Ko SH

Purpose: This study aims to understand the characteristics of smart device-based testing (SBT) by comparing the typical characteristics of students’ satisfaction with SBT, its usefulness, advantages, and disadvantages when compared...
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Proton pump inhibitor use is associated with hip fracture development: a nationwide populationbased cohort study

Min YW, Lee YC, Kim K, Ryu S, Hong KS, Jeon H, Kim YS, Park JH, Son HJ, Rhee PL

Background/Aims: Effect of proton pump inhibitor (PPI) use on the risk of hip fracture is controversial. This study aimed to clarify the association between PPI use and hip fracture risk using a...
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Clinical and Radiological Outcomes of Polished Cemented Bipolar Hemiarthroplasty for Intertrochanteric Fractures in Elderly Patients

Kweon SH, Shin CH, Lee YC, Kim MW, Kim TH

Purpose: To evaluate the clinical and radiological outcomes of bipolar hemiarthroplasty using a polished cemented femoral stem for intertrochanteric fractures in elderly patients. Materials and Methods: From July 2005 to May...
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Gene signature for prediction of radiosensitivity in human papillomavirus-negative head and neck squamous cell carcinoma

Kim SI, Kang JW, Noh JK, Jung HR, Lee YC, Lee JW, Kong M, Eun YG

Purpose: The probability of recurrence of cancer after adjuvant or definitive radiotherapy in patients with human papillomavirus-negative (HPV(–)) head and neck squamous cell carcinoma (HNSCC) varies for each patient. This...
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Spinosin Attenuates Alzheimer’s Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity

Cai M, Jung I, Kwon H, Cho E, Jeon J, Yun J, Lee YC, Kim DH, Ryu JH

Hippocampal synaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy....
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Availability of Cycloplegic Refraction in Children and Adolescents

Kim SH, Lee YC

PURPOSE: To compare non-cycloplegic and cycloplegic refractive errors and evaluate the utility of cycloplegia in Korean children and young adolescents. METHODS: An anterospective study including 406 outpatients was conducted from September...
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Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC

PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to...
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Proteins in Outer Membrane Vesicles Produced by Burkholderia cepacia are Responsible for Pro-inflammatory Responses in Epithelial Cells

Kim SY, Kim SI, Yun SH, Shin M, Lee YC, Lee JC

Gram-negative bacterial pathogens produce outer membrane vesicles (OMVs) and this secreted cargo plays a role in host-pathogen interactions. OMVs isolated from Burkholderia cepacia induce the cytotoxicity and pro-inflammatory responses both...
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Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition

Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter and Upper Gastrointestinal Research

Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helico-bacter and Upper Gastrointestinal Research and Korean So-ciety...
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Efficacy of Endoscopic Vacuum-Assisted Closure Treatment for Postoperative Anastomotic Leak in Gastric Cancer

Choi SI, Park JC, Jung DH, Shin SK, Lee SK, Lee YC

Background/Aims: Endoscopic vacuum-assisted closure (EVAC) has been attempted as new nonsurgical treatment for anastomotic leakage. We aimed to evaluate the clinical outcomes of EVAC and compare its efficacy with the...
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Evaluation of the optimal sequence of adjuvant chemotherapy and radiation therapy in the treatment of advanced endometrial cancer

McEachron J, Zhou N, Spencer C, Shanahan L, Chatterton C, Singhal P, Lee YC

Objective: The optimal sequence of adjuvant chemoradiation in the treatment of advanced endometrial carcinoma (EC) remains unclear. We sought to evaluate the outcomes of patients treated with chemoradiation in sandwich...
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Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole

Wu JCY, Sheu BS, Wu MS, Lee YC, Choi MG

  • KMID: 2500653
  • J Neurogastroenterol Motil.
  • 2020 Jan;26(1):85-95.
  • doi: 10.5056/jnm19031
Background/Aims Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of...
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β-Amyrin Ameliorates Alzheimer’s Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus

Park HJ, Kwon H, Lee JH, Cho E, Lee YC, Moon M, Jun M, Kim DH, Jung JW

Alzheimer’s disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface...
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Ten-Day Concomitant, 10-Day Sequential, and 7-Day Triple Therapy as First-Line Treatment for Helicobacter pylori Infection: A Nationwide Randomized Trial in Korea

Kim BJ, Lee H, Lee YC, Jeon SW, Kim GH, Kim HS, Sung JK, Lee DH, Kim HU, Park MI, Choi IJ, Yoon SM, Kim SW, Baik GH, Lee JY, Kim JI, Kim SG, Kim J, Lee J, Kim JG, Kim JJ, Korean College of Helicobacter and Upper Gastrointestinal Research

BACKGROUND/AIMS: This nationwide, multicenter prospective randomized controlled trial aimed to compare the efficacy and safety of 10-day concomitant therapy (CT) and 10-day sequential therapy (ST) with 7-day clarithromycin-containing triple therapy...
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Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer

An AR, Kim KM, Park HS, Jang KY, Moon WS, Kang MJ, Lee YC, Kim JH, Chae HJ, Chung MJ

BACKGROUND: Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes,...
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