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Restorative Mechanism of Neural Progenitor Cells Overexpressing Arginine Decarboxylase Genes Following Ischemic Injury

Kim JY, Kim JY, Kim JH, Jung H, Lee WT, Lee JE

Cell replacement therapy using neural progenitor cells (NPCs) following ischemic stroke is a promising potential therapeutic strategy, but lacks efficacy for human central nervous system (CNS) therapeutics. In a previous...
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M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain

Choi JY, Kim JY, Kim JY, Park J, Lee WT, Lee JE

Microglia play a key role in the immune response and inflammatory reaction that occurs in response to ischemic stroke. Activated microglia promote neuronal damage or protection in injured brain tissue....
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Endogenous Agmatine Induced by Ischemic Preconditioning Regulates Ischemic Tolerance Following Cerebral Ischemia

Kim JH, Kim JY, Jung JY, Lee YW, Lee WT, Huh SK, Lee JE

Ischemic preconditioning (IP) is one of the most important endogenous mechanisms that protect the cells against ischemia-reperfusion (I/R) injury. However, the exact molecular mechanisms remain unclear. In this study, we...
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Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury

Kim JY, Lee YW, Kim JH, Lee WT, Park KA, Lee JE

Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after...
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Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model

Song J, Hur BE, Bokara KK, Yang W, Cho HJ, Park KA, Lee WT, Lee KM, Lee JE

PURPOSE: Alzheimer's disease (AD) results in memory impairment and neuronal cell death in the brain. Previous studies demonstrated that intracerebroventricular administration of streptozotocin (STZ) induces pathological and behavioral alterations similar...
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Glutathione Protects Brain Endothelial Cells from Hydrogen Peroxide-Induced Oxidative Stress by Increasing Nrf2 Expression

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE

Glutathione (GSH) protects cells against oxidative stress by playing an antioxidant role. Protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer's...
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TRPV1 Activation in Primary Cortical Neurons Induces Calcium-Dependent Programmed Cell Death

Song J, Lee JH, Lee SH, Park KA, Lee WT, Lee JE

Transient receptor potential cation channel, subfamily V, member 1 (TRPV1, also known as vanilloid receptor 1) is a receptor that detects capsaicin, a pungent component of chili peppers, and noxious...
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Expression of transient receptor potential channels in the ependymal cells of the developing rat brain

Jo KD, Lee KS, Lee WT, Hur MS, Kim HJ

Cerebrospinal fluid (CSF) plays an important role in providing brain tissue with a stable internal environment as well as in absorbing mechanical and thermal stresses. From its initial composition, derived...
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Overexpression of Human Arginine Decarboxylase Rescues Human Mesenchymal Stem Cells against H2O2 Toxicity through Cell Survival Protein Activation

Seo SK, Yang W, Park YM, Lee WT, Park KA, Lee JE

In this study, we explored the potentiality of human arginine decarboxylase (ADC) to enhance the survival of mesenchymal stem cells (MSCs) against unfavorable milieu of host tissues as the low...
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The Effect of Agmatine on Expression of IL-1beta and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors

Song J, Kumar BK, Kang S, Park KA, Lee WT, Lee JE

Differentiation of neural progenitor cells (NPCs) is important for protecting neural cells and brain tissue during inflammation. Interleukin-1 beta (IL-1beta) is the most common pro- inflammatory cytokine in brain inflammation,...
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Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury

Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE

  • KMID: 2154288
  • Exp Mol Med.
  • 2013 Dec;45(12):e69.
Neural stem cells (NSCs) have been suggested as a groundbreaking solution for stroke patients because they have the potential for self-renewal and differentiation into neurons. The differentiation of NSCs into...
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Spondylolisthesis Accompanying Bilateral Pedicle Stress Fracture at Two Vertebrae

Kim HS, Kim SW, Lee WT

There has been no report of bilateral pedicle stress fractures involving two vertebrae. The authors describe a unique case of spondylolisthesis accompanying a bilateral pedicle stress fracture involving two vertebrae....
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Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain

Mun CH, Lee WT, Park KA, Lee JE

Nitric oxide (NO) production by endothelial nitric oxide synthase (eNOS) plays a protective role in cerebral ischemia by maintaining vascular permeability, whereas NO derived from neuronal and inducible NOS is...
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Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia

Uranchimeg D, Kim JH, Kim JY, Lee WT, Park KA, Batbaatar , Tundevrentsen S, Amgalanbaatar D, Lee JE

Stroke or cerebrovascular injury is the leading cause of disability and the third leading cause of deaths worldwide. After the initial ischemic injury, sympathetic signals are transmitted to the spleen...
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Null and Duplicated Alleles of 17 Y-STR Haplotypes in Koreans and Considerations for Forensic Application

Cho NS, Yoo SY, Hwang JH, Seong KM, Chung NE, Lee WT

  • KMID: 2305493
  • Korean J Leg Med.
  • 2010 Nov;34(2):147-151.
The analysis of Y chromosome polymorphisms has become common place for the identification of male component in forensic cases. In male/female mixtures of many rape cases, Y-STRs are also very...
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Agmatine Attenuates Nitric Oxide Synthesis and Protects ER-structure from Global Cerebral Ischemia in Rats

Mun CH, Kim JH, Park KA, Lee WT, Baik JH, Lee JE

  • KMID: 1472487
  • Korean J Anat.
  • 2009 Sep;42(3):149-160.
In ischemic strokes, apoptosis is caused by excitotoxicity, ionic imbalance, oxidative/nitrosative stress, and apoptotic-like pathways. Nitric oxide (NO), a free radical, is elevated after ischemic insult. NO, which is generated...
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Analysis of 12 Autopsy Cases related with Insurance Money

Kim YS, Lee HY, Yang KM, Kwon IH, Lee H, Park MI, Kim DJ, Park JW, Choi CH, Lee JH, Lee WT

  • KMID: 2250379
  • Korean J Leg Med.
  • 2008 May;32(1):13-23.
Life insurance has been developed in means of providing economic compensation for unexpected accidental losses. As the insurance industry of Korea grows along with improvement of economic state, the life...
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The Effect of Agmatine on Expression of MMP2 and MMP9 in Cerebral Ischemia

Kim JH, Lee YW, Kim JY, Lee WT, Park KA, Lee JE

  • KMID: 2092923
  • Korean J Anat.
  • 2008 Mar;41(1):97-104.
Agmatine is a primary amine formed by decarboxylation of L-arginine synthesized in the mammalian brain. Recent studies have shown that agmatine is neuroprotective in models of trauma and ischemia. The...
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Preliminary Research for Applying Appraisal Techniques to Evaluate the Cause of Skin Injury

Yang KM, Chung NE, Hong S, Moon KW, Lee J, Kim DK, Kang H, Kim DW, Lee YS, Kim KW, Joh GW, Park SJ, Kim JS, Jeon SH, Seo JS, Lee WT

  • KMID: 1269686
  • Korean J Leg Med.
  • 2008 Nov;32(2):105-110.
In the field of the forensic medicine, deciding the cause of the injury is very important. Forensic doctors usually use their naked eyes, two dimensional photos, the characteristics and the...
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Human Papilloma Virus Type 16 E7 Oncoprotein Stabilizes p53 Protein but not Induced p53-mediated Apoptosis in HepG2 Cells after gamma-irradiation under Hypoxia

Hwang HJ, Choi EJ, Choi YJ, Lee WT, Park KA, Lee JE

  • KMID: 2092894
  • Korean J Anat.
  • 2007 Jun;40(2):95-106.
Human papilloma virus 16 E6 and E7 oncoproteins are well known to change cell functions, especially through p53 and pRb expression, so we studied their effects on molecular mechanisms and...
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