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Relationship between Hearing Loss and Dementia Differs According to the Underlying Mechanism

Jung J, Bae SH, Han JH, Kwak SH, Nam GS, Lee PH, Sohn YH, Yun M, Ye BS

Background and Purpose The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI)...
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Current Status of COVID-19 Vaccine Development: Focusing on Antigen Design and Clinical Trials on Later Stages

Lee P, Kim CU, Seo SH, Kim DJ

The global outbreak of coronavirus disease 2019 (COVID-19) is still threatening human health, economy, and social life worldwide. As a counteraction for this devastating disease, a number of vaccines are...
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N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression

Lee PH, Hong J, Jang AS

Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism...
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Emerging Concepts of Motor Reserve in Parkinson’s Disease

Chung SJ, Lee JJ, Lee PH, Sohn YH

The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits...
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Newly Emerging Human Coronaviruses: Animal Models and Vaccine Research for SARS, MERS, and COVID-19

Lee P, Kim DJ

The recent emergence of the novel coronavirus (CoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a global threat to human health and economy. As of June 26, 2020, over...
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Recombinant zoster vaccine (Shingrix®): a new option for the prevention of herpes zoster and postherpetic neuralgia

Singh G, Song S, Choi E, Lee PB, Nahm FS

Postherpetic neuralgia (PHN) is a challenging condition for pain management specialists. The prevention of herpes zoster (HZ) and subsequent PHN in individuals aged 50 years and older, via the development...
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Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure

Ho CM, Chen YH, Chien CS, Ho SL, Chen HL, Hu RH, Lee PH

Background: Cell therapy is considered a potential alternative to liver transplantation in acute liver failure (ALF). We aimed to evaluate the add-on therapeutic benefit of hepatocyte and mesenchymal stem cell...
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Structural and Resting-State Brain Alterations in Trauma-Exposed Firefighters: Preliminary Results

Park YW, Jun S, Noh J, Chung SJ, Han S, Lee PH, Kim C, Lee SK

Purpose To analyze the altered brain regions and intrinsic brain activity patterns in trauma-exposed firefighters without posttraumatic stress disorder (PTSD). Materials and Methods Resting-state functional MRI (rsfMRI) was performed for all...
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Association between Olfactory Deficit and Motor and Cognitive Function in Parkinson’s Disease

Yoo HS, Chung SJ, Lee YH, Ye BS, Sohn YH, Lee PH

Objective To investigate whether baseline olfactory dysfunction in Parkinson’s disease (PD) patients is associated with baseline and longitudinal motor and cognitive function. Methods We recruited 228 drug-naïve PD patients who were...
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Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome

Nahm FS, Lee JS, Lee PB, Choi E, Han WK, Nahm SS

Background: Among various diseases that accompany pain, complex regional pain syndrome (CRPS) is one of the most frustrating for patients and physicians. Recently, many studies have shown functional and anatomical...
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The Safe Conduct of Echocardiographic Studies During the COVID-19 Pandemic: Perspectives and Experience from a Tertiary Echocardiography Laboratory in Singapore

Koh CH, Chiong SC, Lee PT, Ding ZP, Ewe SH

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Validation of the Korean Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale

Choi JH, Lee JY, Cho JW, Ko SB, Ahn TB, Kim SJ, Cheon SM, Kim JS, Kim YJ, Ma HI, Baik JS, Lee PH, Chung SJ, Kim JM, Song IU, Kim HJ, Sung YH, Kwon DY, Lee JH, Kim JY, Kim JS, Yun JY, Kim HJ, Hong JY, Kim MJK, Youn J, Kim JSK, Oh ES, Yang HJ, Yoon WT, You S, Kwon KY, Park HE, Lee SY, Kim Y, Kim HT, Park MY

Background and Purpose Impulse-control disorder is an important nonmotor symptom of Parkinson's disease (PD) that can lead to financial and social problems, and be related to a poor quality of life....
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ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB

Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene...
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A Characteristic Finding of Spontaneous Coronary Artery Dissection by Computed Tomographic Angiography

Kim AR, Koo HJ, Lee PH

No abstract available.
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Serum Calprotectin Is a Potential Marker in Patients with Asthma

Lee YG, Hong Js, Lee PH, Lee Jh, Park SW, Kim DJ, Jang AS

Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic...
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Validation Study of the Official Korean Version of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale

Park J, Koh SB, Kwon KY, Kim SJ, Kim JW, Kim JS, Park KW, Paik JS, Sohn YH, Ahn JY, Oh E, Youn J, Lee JY, Lee PH, Jang W, Kim HJ, Jeon BS, Chung SJ, Cho JW, Cheon SM, Kang SY, Park MY, Park S, Huh YE, Kang SJ, Kim HT

Background and Purpose: The Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) is widely used for estimating the symptoms of Parkinson’s disease. Translation and validation of...
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Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver

Kao YH, Lin YC, Lee PH, Lin CW, Chen PH, Tai TS, Chang YC, Chou MH, Chang CY, Sun CK

BACKGROUND: This study investigated whether xenotransplantation of human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) reduces thioacetamide (TAA)-induced mouse liver fibrosis and the underlying molecular mechanism. METHODS: Recipient NOD/SCID mice were injected...
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Topical agents: a thoughtful choice for multimodal analgesia

Choi E, Nahm FS, Han WK, Lee PB, Jo J

For over a thousand years, various substances have been applied to the skin to treat pain. Some of these substances have active ingredients that we still use today. However,...
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A Case of Abnormal Postures in the Left Extremities after Pontine Hemorrhage: Dystonia or Pseudodystonia?

Park CW, Chung SJ, Sohn YH, Lee PH

It is difficult to determine the pathoanatomical correlates of dystonia because of its complex pathophysiology, and most cases with secondary dystonia are associated with basal ganglia lesions. Moreover, it is...
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Radiation exposure to the eyes and thyroid during C-arm fluoroscopy-guided cervical epidural injections is far below the safety limit

Choi EJ, Go G, Han WK, Lee PB

Background: The aim of this study was to evaluate radiation exposure to the eye and thyroid in pain physicians during the fluoroscopy-guided cervical epidural block (CEB). Methods: Two pain physicians (a...
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