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A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity

Ahn JH, Lee BH, Kim SE, Kwon BE, Jeong H, Choi JR, Kim MJ, Park Y, Kim BS, Kim DH, Ko HJ

Multiple myeloma is a malignant cancer of plasma cells. Despite recent progress with immunomodulatory drugs and proteasome inhibitors, it remains an incurable disease that requires other strategies to overcome its...
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Nonepisodic angioedema with eosinophilia: A case report of a Korean patient

Choi J, Park SY, Moon KT, Lee WM, Lee BH, Kim SH

Nonepisodic angioedema with eosinophilia (NEAE) is a rare disease characterized by nonrecurrent angioedema with eosinophilia and normal serum IgM levels occurring predominantly in an East Asian female population. A 49-year-old...
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Surgical Interventions and Clinical Outcomes of Patients with Trisomy 18: a Single Center Experience

Oh MY, Lee BS, Cha T, Jeong J, Jung E, Kim EAR, Kim KS, Lee BH, Yoo HW

Objective: The purpose of this study was to investigate the impact of surgical interventions on the survival rate of the trisomy 18 and to provide the clinical information of the...
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Prevalence of Gastrointestinal and Cardiovascular Risk in Patients with Degenerative Lumbar Spinal Disease

Yang JH, Lee BH, Eum KS, Suk KS, Park JO, Kim HS, Lee HM, Moon SH

Background: Limited information is available about the proportion of patients with degenerative lumbar spinal disease (DLSD) who have gastrointestinal (GI) and cardiovascular (CV) risk factors. Many DLSD patients are prescribed...
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KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure

Lee JH, Seo HW, Ryu JY, Lim CJ, Yi KY, Oh KS, Lee BH

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of...
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The role of platelet function analyzer-200 in predicting perioperative bleeding risk

Yu ES, Jeon MJ, Kang KW, Lee BH, Kang EJ, Park Y, Lee SR, Sung HJ, Choi CW, Kim BS, Kim DS

Background/Aims: Various preoperative screening tests, such as platelet count, prothrombin time, activated partial thromboplastin time, and bleeding time, have been widely used to evaluate the risk of bleeding during surgery....
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A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment

Chin J, Kim DE, Lee H, Yun J, Lee BH, Park J, Yeom J, Shin DS, Na DL

Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results....
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Psychological Impact of Quarantine on Caregivers at a Children's Hospital for Contact with Case of COVID-19

Kim H, Park KJ, Shin YW, Lee JS, Chung S, Lee T, Kim MJ, Jung J, Lee J, Yum MS, Lee BH, Koh KN, Ko TS, Lim E, Lee JS, Lee JY, Choi JY, Han HM, Shin WA, Lee NJ, Kim SH, Kim HW

Quarantine often provokes negative psychological consequences. Thus, we aimed to identify the psychological and behavioral responses and stressors of caregivers quarantined with young patients after a close contact to a...
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Beckwith-Wiedemann Syndrome and Jacobsen Syndrome Caused by 11pter Duplication and 11qter Deletion Inherited from Paternal Pericentric Inversion

Choi WK, Lim SE, Kim GH, Lee BH, Seol CA, Seo EJ

We report a case of Beckwith-Wiedemann syndrome (BWS) and Jacobsen syndrome (JBS) due to 11pter trisomy and 11qter monosomy caused by paternal inv(11)(p15.1q24.2). The patient was born premature and had...
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Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia

Jeon MJ, Yu ES, Kang KW, Lee BH, Park Y, Lee SR, Sung HJ, Yoon SY, Choi CW, Kim BS, Kim DS

Background/Aims: The diagnosis of immune thrombocytopenia (ITP) is based on clinical manifestations and there is no gold standard. Thus, even hematologic malignancy is sometimes misdiagnosed as ITP and adequate treatment...
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A Novel COL4A1 Mutation in a Neonate with Intrauterine Intraventricular Hemorrhage and Porencephaly

Noh J, Jung E, Jung AY, Lee BH, Lee BS, Kim EAR, Kim KS

Collagen type IV alpha 1 (COL4A1) plays an important role in construction of the basement membranes of all human tissues, especially vessels. Mutations in COL4A1 lead to various multisystemic...
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Arthrodesis Using Bilateral Dual Iliac Screws with Autologous Iliac Bone Transfer for the Treatment of Pyogenic Sacroiliitis

Kwon JW, Shin JK, Moon SH, Lee HM, Lee BH

Pyogenic sacroiliitis is a relatively rare condition that often leads to surgical treatment, including debridement and arthrodesis. Here we introduce a new surgical technique using bilateral dual iliac screws to...
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Hypotonia, Ataxia, and Delayed Development Syndrome caused by the EBF3 mutation in a Korean boy with muscle hypotonia

Kim TG, Choi YH, Lee YN, Kang MJ, Seo GH, Lee BH

Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS) is an autosomal-dominant, extremely rare neurodevelopmental disorder caused by the heterozygous EBF3 gene mutation. EBF3 is located on chromosome 10q26.3 and acts as...
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Refractory hyperkalemia caused by ACE gene mutation in a 3-yearold girl with kidney transplantation: a case report

Kim JY, Lee BH, Cho H

Background: Renal tubular dysgenesis (RTD) is rare and mostly fatal disease caused by genetic defect in renin-angiotensin system (RAS) presenting poor or absent development of proximal tubule. We report a...
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Superior Mesenteric Venous Thrombophlebitis with Terminal Ileal Diverticulitis: A Case Report

Park Yi, Kim YH, Lee BH

Mesenteric venous thrombophlebitis secondary to inflammatory processes such as diverticulitis and appendicitis is a rare disease; however, it can nonetheless cause bowel ischemia and infarctions. Radiologic diagnosis is vital for...
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A Self-Efficacy Promotion Program for the Continuation of Breastfeeding for Mothers of Premature Infants

Lee Bh, Bang KS

Purpose: This study examined the effects of breastfeeding education among preterm mothers. Methods: A nonequivalent control group, repeated measure, quasi-experimental study design was used. The participants comprised 46 preterm mothers...
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Fungal Clusters and Their Uniqueness in Geographically Segregated Wetlands: A Step Forward to Marsh Conservation for a Wealth of Future Fungal Resources

Park JM, Hong JW, Lee W, Lee BH, You YH

Here, we investigated fungal microbiota in the understory root layer of representative well-conserved geographically segregated natural wetlands in the Korean Peninsula. We obtained 574,143 quality fungal sequences in total from...
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Periprosthetic Fractures following Total Knee Arthroplasty

Lee BH, Sim JA

Recently, as the elderly population increases, the incidence of total knee arthroplasty has increased, with a concomitant increase in the frequency of periprosthetic fractures. To determine the treatment plan for...
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Novel ATP8B1 Gene Mutations in a Child with Progressive Familial Intrahepatic Cholestasis Type 1

Rhee ES, Kim YB, Lee S, Oh SH, Lee BH, Kim KM, Yoo HW

Progressive familial intrahepatic cholestasis (PFIC) is a group of severe genetic disorders, inherited in an autosomal recessive manner, causing cholestasis of hepatocellular origin, later progressing to biliary cirrhosis and liver...
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Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease

Ahn SB, Jun DW, Jang K, Lee BH, Shin KJ

BACKGROUND/AIMS: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its...
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