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The Baseline Serum IgG4/IgG3 Ratio Might be a Suitable Marker for Predicting Favorable Treatment Response in Patients With Idiopathic Retroperitoneal Fibrosis-associated Hydronephrosis

Kwok SK

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1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis

Kim H, Baek S, Hong SM, Lee J, Jung SM, Lee J, Cho ML, Kwok SK, Park SH

BACKGROUND: Immune cells express the vitamin (vit) D receptor, and vit D is a potent immune-modulator. A negative correlation between serum vit D levels and rheumatoid arthritis (RA) disease activity...
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Type I Interferon Increases Inflammasomes Associated Pyroptosis in the Salivary Glands of Patients with Primary Sjögren's Syndrome

Hong SM, Lee J, Jang SG, Lee J, Cho ML, Kwok SK, Park SH

Sjögren's syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration in the exocrine glands. In SS, type I IFN has a pathogenic role, and recently, inflammasome...
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Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort

Min HK, Lee J, Ju JH, Kwok SK, Youn HJ, Park SH

OBJECTIVE: Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA...
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Risk of malignancy in patients with rheumatoid arthritis after anti-tumor necrosis factor therapy: results from Korean National Health Insurance claims data

Jung SM, Kwok SK, Ju JH, Park YB, Park SH

BACKGROUND/AIMS: Inhibition of tumor necrosis factor (TNF) is an effective treatment for rheumatoid arthritis (RA), but safety concerns about malignancy remain. The aim of this study was to evaluate cancer...
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Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI

Kim JW, Park JB, Yim HW, Lee J, Kwok SK, Ju JH, Kim WU, Park SH

BACKGROUND/AIMS: To examine the association between rheumatoid arthritis (RA) and periodontitis or tooth loss. METHODS: The study used data from the fifth and sixth Korea National Health and Nutrition Examination Surveys...
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Longitudinal Changes of the European League Against Rheumatism Sjögren's Syndrome Patient Reported Index in Korean Patients with Primary Sjögren's Syndrome

Kwok SK

No abstract available.
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Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor

Min HK, Lee YS, Yang SW, Lee J, Kwok SK, Ju JH, Kim WU, Park SH

BACKGROUND/AIMS: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor. METHODS: We retrospectively...
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Insulin resistance is an independent predictor of erectile dysfunction in patients with gout

Kim JH, Chung MK, Kang JY, Koh JH, Lee J, Kwok SK, Ju JH, Park SH

BACKGROUND/AIMS: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with...
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Erratum: Effects of Individual Education Using a Treating-to-target Strategy in Patients with Rheumatoid Arthritis

Paek SI, Jung SM, Lee J, Kwok SK, Kim WU, Park SH, Ju JH, Sohng KY

The original version of this article contained an error of the ORCID identifier of corresponding author (Ji Hyeon Ju).
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Sodium Chloride Aggravates Arthritis via Th17 Polarization

Jung SM, Kim Y, Kim J, Jung H, Yi H, Rim YA, Park N, Kwok SK, Park SH, Ju JH

PURPOSE: Sodium chloride (NaCl) has been proposed as a driving factor in autoimmune diseases through the induction of pathogenic CD4+ T helper cells that produce interleukin-17 (Th17 cells). This study...
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New insights into the role of renal resident cells in the pathogenesis of lupus nephritis

Kwok SK, Tsokos GC

Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE...
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Effects of Individual Education Using a Treating-to-target Strategy in Patients with Rheumatoid Arthritis

Paek SI, Jung SM, Lee J, Kwok SK, Kim WU, Park SH, Ju JH, Sohng KY

OBJECTIVE: To examine effects of an individual education program using the treating rheumatoid arthritis to target (RA T2T) strategy in patients with moderate-severe rheumatoid arthritis. METHODS: Patients were assigned randomly to...
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Detection of Autoantibodies against Aquaporin-1 in the Sera of Patients with Primary Sjögren's Syndrome

Alam J, Choi YS, Koh JH, Kwok SK, Park SH, Song YW, Park K, Choi Y

The pathophysiology of glandular dysfunction in Sjögren's syndrome (SS) has not been fully elucidated. Previously, we reported the presence of autoantibodies to AQP-5 in patients with SS, which was associated...
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Interleukin-17 Enhances Germinal Center Formation and Immunoglobulin G1 Production in Mice

Lee J, Lee SY, Kang CM, Jhun JY, Kim JH, Cho ML, Park SH, Kim HY, Kwok SK

OBJECTIVE: Interleukin (IL)-17 is a pro-inflammatory cytokine that has pleiotropic effects on multiple target cells and thereby contributes to the development of immune-mediated inflammatory disorders. However, the role of IL-17...
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Autonomic dysfunction in primary Sjogren's syndrome: a prospective cohort analysis of 154 Korean patients

Koh JH, Kwok SK, Lee J, Park SH

BACKGROUND/AIMS: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren's syndrome (pSS) and its associations with the clinical features of pSS. METHODS: We analyzed 154 participants from...
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The Therapeutic Effect of Sauchinone on Inflammatory Arthritis in Mice

Jung SM, Lee J, Lee J, Baek SY, Park SH, Kwok SK

OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory disease, mainly involving joints and bones. Sauchinone is an anti-inflammatory agent isolated from Saururus chinensis, which was used in oriental medicine. The...
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Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjögren's Syndrome

Lee J, Koh JH, Kwok SK, Park SH

This study was conducted to generate and validate a cross-culturally adapted Korean version of the xerostomia inventory (XI), an 11-item questionnaire designed to measure the severity of xerostomia. The original...
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Review of Sjogren's Syndrome for Primary Physicians

Kwok SK

Sjogren's syndrome is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands resulting in a dry mouth and eyes. The disease can present either alone or...
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Extraglandular Manifestations of Korean Patients with Primary Sjogren's Syndrome

Kwok SK

No abstract available.
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