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Correlation between Morphologic Grading and Euploidy Rates of Blastocysts, and Clinical Outcomes in In Vitro Fertilization Preimplantation Genetic Screening

Kim MK, Park JK, Jeon Y, Choe SA, Lee HJ, Kim J, Chang EM, Kim JW, Lyu SW, Kim JY, Kwak IP, Lee WS, Yoon TK

BACKGROUND: The standard morphological evaluation has been widely used for embryo selection, but it has limitations. This study aimed to investigate the correlation between morphologic grading and euploidy rate of...
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Efficacy of Assisted Hatching by Laser in Human IVF-ET Program

Lee JH, Han JE, Kim YS, Won HJ, Cho CH, Kwak IP, Eum JH, Park EA, Choi YJ, Lee DR, Yoon TK

  • KMID: 1764125
  • Korean J Reprod Med.
  • 2008 Sep;35(3):193-202.
OBJECTIVE: To evaluate efficacy of assisted hatching by laser (AHL) and acidified Tyrode solution (AHA) in selected groups of IVF-ET patients who have a poor prognosis. METHODS: From February 2006 to...
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Management of Recurrent Pregnancy Loss

Kwak IP

Recurrent pregnancy loss (RPL) is defined as three or more consecutive spontaneous abortions. It affects about 1% of couples attempting pregnancy. Most of these pregnancy losses are unrecognized. Among the...
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An analysis of various factors affecting postpartum umbilical cord blood volume for hematopoietic stem cell transplantation

Kang SH, Kwak IP, Lee SH, Lee KJ, Kim SH, Baek JY, Kim DK

  • KMID: 2272762
  • Korean J Obstet Gynecol.
  • 2006 Jan;49(1):76-83.
OBJECTIVE: Umbilical cord blood is an effective alternative to bone marrow as a source of hematopoietic stem cells for transplantation. But the amount of collected umbilical cord blood and its...
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Clinical efficacy of GnRH antagonist multiple dose protocol and GnRH agonist long protocol in controlled ovarian hyperstimulation using rFSH in IVF-ET patients

Won HJ, Lee WS, Cho JH, Kim YS, Han JE, Kwak IP, Lee SH, Yoon TK

  • KMID: 2077530
  • Korean J Obstet Gynecol.
  • 2005 Dec;48(12):2941-2948.
OBJECTIVE: To compare the efficacy of GnRH antagonist multi dose protocol in controlled ovarian hyperstimulation (COH) for IVF-ET or ICSI with GnRH agonist long protocol. METHODS: From January 2003 to December...
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The Study of 5,10-Methylenetetrahydrofolate Reductase Variation (MTHFR C677T) in Infertile Females with Polycystic Ovarian Syndrome (PCOS) in Korea

Lee KW, Jeong YM, Lee SH, Yoon TK, Kwak IP, Yoon SW, Choi JS, Kim KH, Han JS, Kim SD, Kim NK, Cha KY, Baek KH, Lee S

  • KMID: 1864647
  • Korean J Fertil Steril.
  • 2003 Sep;30(3):217-222.
OBJECTIVE: To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. MATERIALS AND METHODS: We compared 86 infertile females with polycystic ovarian syndrome...
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Accumulation of mtDNA Deletion (Delta mtDNA4977) showing Tissue-Specific and Age-Related Variation

Jeong HJ, Chung HM, Cho SW, Kim HA, Lee KS, Kwon H, Choi DH, Kwak IP, Yoon TK, Lee SH

  • KMID: 1864645
  • Korean J Fertil Steril.
  • 2003 Sep;30(3):203-206.
OBJECTIVES: Controversial arguments exists on both the case for and against on the accumulation of mitochondrial DNA (mtDNA) deletion in association to tissue and age. The debate continues as to...
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The Analysis of SHP (Small Heterodimer Partner) Gene Mutation in Infertile Patients with Polycystic Ovary Syndrome (PCOS) in Korea

Lee S, Choi HS, Lee SH, Han JH, Nam BH, Kwak IP, Nam YS, Kim NK, Lee KW, Jeon HS

  • KMID: 1891263
  • Korean J Fertil Steril.
  • 2001 Jun;28(2):141-146.
OBJECTIVE: We inversigated Small Heterodimer Partner (SHP) gene mutation in Korean Polycystic Ovarian Syndrome (PCOS) patients. SHP protein regulates the activity of nuclear receptors which regulate the cellular development and...
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Intravenous immunoglobulin for patients with repeated failure of in vitro fertilization-embryo transfer

Lee SH, Youn NY, Yoon TK, Kwak IP, Lee EJ, Choi DH, Han SY

  • KMID: 2261776
  • Korean J Obstet Gynecol.
  • 2000 Jan;43(1):22-25.
OBJECTIVE: The implantation failure after embryo-transfer (ET) is a major continuing problem in in vitro fertilization (IVF). This study was undertaken to determine the effectiveness of intravenous immunoglobulin for treatment...
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A Case of Azoospermia Associated with Yq Deletion

Nam YS, Kim HJ, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2235744
  • Korean J Fertil Steril.
  • 1999 Aug;26(2):293-296.
Different Y mutation in Yq11 occurring de novo in sterile males were first described 19 years ago. Since the phenotype of the patients was always associated with azoospermia or severe...
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A Case of Acanthosis Nigricans Detected in Obese Infertile Woman

Nam YS, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2269622
  • Korean J Obstet Gynecol.
  • 1999 May;42(5):1120-1122.
Acanthosis nigricans[AN] is a dermatopathy with a distinctive appearance that facilitates its diagnosis. Although an external condition, it is associated with a wide variety of less obvious internal...
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A Case of Multifetal Pregnancy Complicated by Single Anomalous Fetus

Nam YS, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2075731
  • Korean J Obstet Gynecol.
  • 1999 Apr;42(4):891-895.
When complications arise in a multifetal gestation, management decisions can be very difficult for both parents and physicians because the fates of sibling fetuses are linked. The overall pregnancy outcome...
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A Case of Noonan Syndrome

Nam YS, Kim IK, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2075730
  • Korean J Obstet Gynecol.
  • 1999 Apr;42(4):887-890.
Noonan syndrome is featured by short stature, mental retardation, hypertelorism, epicanthal folds, dental malocclusion, pectus excavatum and congenital heart disease[mainly ventricular septal defects and pulmonary stenosis]. The phenotype has some...
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A Case of Azoospermia Associated with Y - Autosome Translocation

Lee SH, Yoon TK, Cha KY, Kwak IP, Kim HJ, Nam YS

  • KMID: 2261375
  • Korean J Obstet Gynecol.
  • 1999 Mar;42(3):625-627.
Aneuploidy results from nondisjunction in either the meiotic division of the parents or the early cleavage divisions of the affected individuals. The sex chromosomes show a wide range of viable...
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A Case of HAIR - AN Syndrome

Lee SH, Yoon TK, Cha KY, Kwak IP, Nam YS

  • KMID: 2261374
  • Korean J Obstet Gynecol.
  • 1999 Mar;42(3):622-624.
Polycystic ovary disease is a heterogenous endocrinopathy with many interacting causal factors. One potential such factor is chronic hyperinsulinemia. multiple, independent lines of evidence suppart the contention that chronic hyperinsulinemia...
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Analysis of Chromosomal Abnormalities of Sperm from Patients with Advanced Age by FISH Method

Lee SH, Yoon TK, Cha KY, Kwak IP, Lee JH, Oum KB, Shon JO, Ko JJ

  • KMID: 2261300
  • Korean J Obstet Gynecol.
  • 1999 Feb;42(2):260-263.
Determmation of the chomosomal constitution of human spermatozoa has been camed out though the human-hamster interspecific in vitro fertilization(IVF) system. In recent years, the introduction of fluorescence in-situ hybridization(FISH) technique...
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A Case of Premature Ovarian Failure Assosiated with Gonadal Dysgenesis

Lee SH, Yoon TK, Cha KY, Nam YS, Kwak IP

  • KMID: 2261273
  • Korean J Obstet Gynecol.
  • 1999 Jan;42(1):138-141.
Prenature ovarian failure is a condition causing amenarrhea, hypoestrogenism, and elevated genadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for...
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Successful pregnancies using frozen thawed testicular sperm in ICSI program

Oum KB, Yoon TK, Cha KY, Kim HJ, Nam YS, Kim HK, Kwak IP, Han SY

  • KMID: 2261268
  • Korean J Obstet Gynecol.
  • 1999 Jan;42(1):104-108.
There are not much reports concerning with clinical results using frozen-thawed testivular sperm in ICSI program. It is speculated that the necessity of cryopreservation of testicular sperm to avoid repeating...
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A Case of Sex-Reversed Male

Nam YS, Kim HJ, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2261125
  • Korean J Obstet Gynecol.
  • 1998 Aug;41(8):2216-2219.
The incidence of XX male reversal is approximately 1 in 20,000 to 1 in 24,000 male births, a rare disorder. The affected individuals are non-ambiguous at birth with normal male...
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A Case of 45 , X/46 , XY Mixed Gonadal Dysgenesis Associated with Azoospermia

Nam YS, Kim HJ, Lee SH, Kwak IP, Yoon TK, Cha KY

  • KMID: 2261124
  • Korean J Obstet Gynecol.
  • 1998 Aug;41(8):2212-2215.
Gonadal dysgenesis traditionally has been based upon phenotypically classified syndromes in which one or both gonads become atretic or streaks. In chromosomally competent ovarian (or gonadal) failure (CCOF) the karyotypes...
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