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Modulatory Effects of Single and Complex Vitamins on the In Vitro Growth of Murine Ovarian Follicles

Kim YY, Kim YJ, Kim H, Kang BC, Ku SY, Suh CS

BACKGROUND: Vitamin is a well-known co-factor for many metabolic processes and its roles in fertility and follicular growth have been studied. Vitamin supplementation is frequently achieved by daily ingestion in...
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Proliferation Profile of Uterine Endometrial Stromal Cells during In Vitro Culture with Gonadotropins: Recombinant versus Urinary Follicle Stimulating Hormone

Kim YJ, Kim YY, Song DY, Lee SH, Park CW, Kim H, Ku SY

BACKGROUND: Provision of optimal endometrial stromal cells is essential in uterine tissue engineering. Culture of these cells is significantly influenced by gonadotropin hormones. This investigation attempted to define the proliferation...
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Efficient Production of Murine Uterine Damage Model

Kim YY, Choi BB, Lim JW, Kim YJ, Kim SY, Ku SY

BACKGROUND: Thin or damaged endometrium causes uterine factor-derived infertility resulting in a failure of embryonic implantation. Regeneration of endometrium is a major issue in gynecology and reproductive medicine. Various types of cells...
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Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy after In Vitro Fertilization and Embryo Transfer

Kim SW, Kim YJ, Shin JH, Kim H, Ku SY, Suh CS, Kim SH, Choi YM

PURPOSE: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. MATERIALS AND METHODS: In this observational study,...
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The Use of Normal Stem Cells and Cancer Stem Cells for Potential Anti-Cancer Therapeutic Strategy

Han SW, Kim YY, Kang WJ, Kim HC, Ku SY, Kang BC, Yun JW

BACKGROUND: Despite recent advance in conventional cancer therapies including surgery, radiotherapy, chemotherapy, and immunotherapy to reduce tumor size, unfortunately cancer mortality and metastatic cancer incidence remain high. Along with a...
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Fertility preservation in pediatric and young adult female cancer patients

Kim H, Kim H, Ku SY

As the 5-year survival rate increases up to 80% in pediatric cancer patients, the number of women patients with reduced gonadal function by chemotherapy and radiotherapy increases. The gonadal toxicity...
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Serum visfatin levels in non-obese women with polycystic ovary syndrome and matched controls

Kim JJ, Choi YM, Hong MA, Kim MJ, Chae SJ, Kim SM, Hwang KR, Yoon SH, Ku SY, Suh CS, Kim SH

OBJECTIVE: The purpose of the current study was to compare the circulating levels of visfatin between women with polycystic ovary syndrome (PCOS) and those without PCOS and to assess the...
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Differential MicroRNA Expression Profile of Human Embryonic Stem Cell-Derived Cardiac Lineage Cells

Kim YY, Min H, Kim H, Choi YM, Liu HC, Ku SY

MicroRNAs (miRNAs) are small non-coding RNA molecules that participate in transcriptional and post-transcriptional regulation of gene expression. miRNAs have numerous roles in cellular function including embryonic development. Human embryonic stem...
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Feature of amenorrhea in postoperative tamoxifen users with breast cancer

Kim H, Han W, Ku SY, Suh CS, Kim SH, Choi YM

OBJECTIVE: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In...
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Effects of Estradiol on the Paracrine Regulator Expression of In Vitro Maturated Murine Ovarian Follicles

Kim YJ, Park KE, Kim YY, Kim H, Ku SY, Suh CS, Kim SH, Choi YM

The preservation of female germ cells is important in the individuals with ovarian dysfunction and failure. For this purpose, ovarian follicle in vitro maturation (OFIVM) is an important technology for...
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Profile of MicroRNA Expression in Endometrial Cell during In Vitro Culture According to Progesterone Concentration

Kim YJ, Kim YY, Kim DW, Joo JK, Kim H, Ku SY

Artificial uterus using endometrium implant can be a novel treatment strategy for infertile women with refractory endometrial dysfunction. At early pregnancy, the function of uterine endometrial cells for the communication...
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The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia

Kim YJ, Tamadon A, Park HT, Kim H, Ku SY

Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones...
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Use of Nonhuman Primates for the Development of Bioengineered Female Reproductive Organs

Yun JW, Kim YY, Ahn JH, Kang BC, Ku SY

Nonhuman primates (NHPs) have been widely used in reproductive biology, neuroscience, and drug development since a number of primate species are phylogenetically close to humans. In this review, we summarize...
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Effects of Estrogen on Intracellular Calcium-Related T-Lymphocyte Function

Kim YY, Kim H, Ku SY, Suh CS, Kim SH, Choi YM, Kim SJ

Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical...
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The Expression Profile of Angiotensin System on Thawed Murine Ovaries

Kim YY, Kim YJ, Cho KM, Kim SH, Park KE, Kang BC, Jung KC, Kim MS, Ku SY

Freezing and thawing is one of the most widely used tissue engineering techniques for the preservation of ovaries. Many cells and tissues demonstrate changes in functional gene expression after thawing....
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Efficient Biomaterials for Tissue Engineering of Female Reproductive Organs

Tamadon A, Park KH, Kim YY, Kang BC, Ku SY

Current investigations on the bioengineering of female reproductive tissues have created new hopes for the women suffering from reproductive organ failure including congenital anomaly of the female reproductive tract or...
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Vitamin D deficiency in women with polycystic ovary syndrome

Kim JJ, Choi YM, Chae SJ, Hwang KR, Yoon SH, Kim MJ, Kim SM, Ku SY, Kim SH, Kim JG

OBJECTIVE: To investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in...
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Carotid intima-media thickness in mainly non-obese women with polycystic ovary syndrome and age-matched controls

Kim JJ, Choi YM, Kang JH, Hwang KR, Chae SJ, Kim SM, Ku SY, Kim SH, Kim JG, Moon SY

  • KMID: 2313957
  • Obstet Gynecol Sci.
  • 2013 Jul;56(4):249-255.
OBJECTIVE: Metabolic disturbances are well-recognized clinical features of polycystic ovary syndrome (PCOS). Carotid intima-media thickness (CIMT) has been widely used as a surrogate marker of atherosclerosis and cardiovascular disease (CVD)....
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Effects of insulin-sensitizing agents and insulin resistance in women with polycystic ovary syndrome

Hwang KR, Choi YM, Kim JJ, Chae SJ, Park KE, Jeon HW, Ku SY, Kim SH, Kim JG, Moon SY

OBJECTIVE: The aim of this study was to investigate the effect of insulin sensitizing agents on hormonal and metabolic parameters as well as menstrual patterns in women with polycystic ovary...
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The Association among Serum Leptin System, Bone Biochemical Markers and Bone Mineral Density Before and After Hormone Therapy

Kim H, Lee HJ, Koh H, Ku SY, Kim SH, Choi YM, Kim JG

  • KMID: 2314129
  • Osteoporosis.
  • 2013 Apr;11(1):9-18.
OBJECTIVES: To investigate the relationships between serum leptin, soluble leptin receptor (sLR) and bone mineral density (BMD) and bone biochemical markers and to evaluate association among these factors after hormone...
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