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Assessment of Hand Motor Function in a Non-human Primate Model of Ischemic Stroke

Won J, Yi KS, Choi CH, Jeon CY, Seo J, Kim K, Yeo HG, Park J, Kim YG, Jin YB, Koo BS, Lim KS, Lee S, Kim KJ, Choi WS, Park SH, Kim YH, Huh JW, Lee SR, Cha SH, Lee Y

  • KMID: 2506534
  • Exp Neurobiol.
  • 2020 Aug;29(4):300-313.
  • doi: 10.5607/en20023
Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. A non-human primate (NHP) model of ischemic stroke was previously developed to investigate its pathophysiology and for efficacy...
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Analysis of Asian Mitochondrial DNA Haplogroups Associated With the Progression of Knee Osteoarthritis in Koreans

Koo BS, Song Y, Lee S, Sung YK, Shin KJ, Cho NH, Jun JB

Objective. We investigated Asian mitochondrial DNA (mtDNA) haplogroups associated with knee osteoarthritis (OA) progression in a prospective community-based cohort comprised of Koreans. Methods. Epidemiologic data and Kellgren-Lawrence (K/L) scores of...
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A Case of Expiratory Limb Filter Obstruction in Heated Circuit Kit

Lee M, Ko EY, Lee SJ, Cho A, Chung YH, Koo BS, Lee JH

Antimicrobial filters that prevent cross-contamination through anesthesia equipment are commonly used in operating rooms. Occlusion of this filter leads to the patient’s airway obstruction, which may lead to fatal outcomes....
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Delayed Detection of Middle Turbinate Fracture after Nasotracheal Intubation: Any Tips for Prevention?

Chung YH, Lee JH, Koo BS, Lee MS, Hong S, Park KN

Nasotracheal intubation is valuable during intra-oral surgery. A common complication of this technique is epistaxis. We experienced a case of middle turbinate fracture which showed no immediate signs of fracture...
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The Significance of Transcriptomic Signatures in the Multifocal Papillary Thyroid Carcinoma: Two mRNA Expression Patterns with Distinctive Clinical Behavior from The Cancer Genome Atlas (TCGA) Database

Kang YE, Hwang B, Lee JH, Shong M, Yi HS, Koo BS, Lee DJ

Background and Objectives: The association between multifocal papillary thyroid carcinoma (PTC) and tumor aggressiveness remains controversial. The aim of study is to evaluate molecular subtypes of multifocal PTCs using multiplatform...
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Recent Trends in the Surgical Treatment of Secondary Hyperparathyroidism

Won HR, Koo BS

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Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis

Koo BS, Jo S, Kwon E, Shin JH, Hur JW, Kim TH

Background/Aims: Biologics are very effective drugs for patients with ankylosing spondylitis (AS). However, there are patients who are not responding to biologics. This study aimed to evaluate the level of...
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Characteristics of Appendicular Tissue Components in Patients with Rheumatoid Arthritis

Koo BS, Yoon BH

BACKGROUND: The purpose of this study was to identify the characteristics of appendicular lean mass (ALM) associated with rheumatoid arthritis (RA) and to analyze appendicular tissue components in patients with...
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Rapid Whole-genome Sequencing of Zika Viruses using Direct RNA Sequencing

Kim JH, Kim J, Koo BS, Oh H, Hong JJ, Hwang ES

Zika virus (ZIKV) is one of the pathogens which is transmitted world widely, but there are no effective drugs and vaccines. Whole genome sequencing (WGS) of viruses could be applied...
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A Case of Langerhans Cell Sarcoma Presenting as Submandibular Gland Mass

Lee G, Song K, Park KW, Koo BS

Langerhans cell sarcoma is a rare, proliferative tumor of Langerhans cells, which shows cytologic characteristics and clinical features of malignant tumor. Langerhans cell sarcoma primarily occurs in lymph nodes, skin,...
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Treatment Outcomes of Vagus Nerve Stimulation in Lennox-Gastaut Syndrome

Kang BS, Woo YS, Lee J, Yi YY, Koo BS, Kang JW

PURPOSE: Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies and frequently patients with this syndrome respond poorly to antiepileptic drugs. The aim of this study was to...
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Treatment Outcomes of Vagus Nerve Stimulation in Lennox-Gastaut Syndrome

Kang BS, Woo YS, Lee J, Yi YY, Koo BS, Kang JW

PURPOSE: Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies and frequently patients with this syndrome respond poorly to antiepileptic drugs. The aim of this study was to...
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Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Koo BS, Lee DH, Kang P, Jeong KJ, Lee S, Kim K, Lee Y, Huh JW, Kim YH, Park SJ, Jin YB, Kim SU, Kim JS, Son Y, Lee SR

Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and...
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Increased CD68/TGFβ Co-expressing Microglia/Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys

Yeo HG, Hong JJ, Lee Y, Yi KS, Jeon CY, Park J, Won J, Seo J, Ahn YJ, Kim K, Baek SH, Hwang EH, Kim G, Jin YB, Jeong KJ, Koo BS, Kang P, Lim KS, Kim SU, Huh JW, Kim YH, Son Y, Kim JS, Choi CH, Cha SH, Lee SR

The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in...
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A suspected sugammadex-induced anaphylactic shock: A case report

Koo BS, Lee SJ, Na HW, Kang WB, Kim SH

BACKGROUND: The reversal of a neuromuscular blockade has typically been achieved with a cholinesterase inhibitor and the concomitant use of an anticholinergic agent, and this remains a popular method. Since...
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Novel porcine model of acute myocardial infarction using polyethylene terephthalate

Kim YS, Kim NY, Bae IH, Park JK, Park DS, Shim JW, Kang WS, Kim HB, Song BS, Koo BS, Jeong KJ, Kim SU, Kim HK, Kim SS, Kim MC, Sim DS, Hong YJ, Ahn Y, Lim KS, Jeong MH

Acute myocardial infarction (AMI) is considered the major cause of mortality in the world. Tremendous animal studies are performed to develop novel therapeutics, and this study aimed to induce porcine...
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Anesthetic Experience of Unexpected Change to One-Lung Ventilation with Bronchial Blocker

Na HW, Lee MS, Cho AN, Chung YH, Lee JH, Cho SH, Koo BS

One-lung ventilation is an anesthesiological technique to accomplish surgical visualization during thoracic surgical procedures, and is often required unexpectedly during surgery. Traditionally the double lumen tube is considered the gold...
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Unanticipated Difficult Intubation in Patient with Undiagnosed Posterior Glottic Stenosis

Lee S, Lee M, Koo BS, Chung YH

Posterior glottic stenosis (PGS) is frequently caused by prolonged intubation complications, which may limit the movement of the vocal cords and obstruct airway obstruction. Despite of a life-threatening condition, it...
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Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling

Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y

Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is...
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Two cases of osseous choristoma on tongue base

Lee G, Won HR, Koo BS, Chang JW

Osseous choristoma is a rare, benign proliferative osseous lesion, which is defined as the growth of normal tissue in an abnormal location. The etiopathogenesis for its formation is unknown, but...
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