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Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers

Yun SJ, Jeong P, Kang HW, Kim YH, Kim EA, Yan C, Choi YK, Kim D, Kim JM, Kim SK, Kim SY, Kim ST, Kim WT, Lee OJ, Koh GY, Moon SK, Kim IY, Kim J, Choi YH, Kim WJ

PURPOSE: MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of...
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COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

Moon HE, Byun K, Park HW, Kim JH, Hur J, Park JS, Jun JK, Kim HS, Paek SL, Kim IK, Hwang JH, Kim JW, Kim DG, Sung YC, Koh GY, Song CW, Lee B, Paek SH

Successful recovery from brain ischemia is limited due to poor vascularization surrounding the ischemic zone. Cell therapy with strong angiogenic factors could be an effective strategy to rescue the ischemic...
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COMP-Angiopoietin-1 Stimulates Synovial Proliferation but Suppresses Osteoclast by Enhancing Angiogenesis and Osteoblast Maturation in Collagen-Induced Arthritis

Jeong YG, Kim HO, Lim HS, Hah YS, Cho HY, Yu J, Park BH, Koh GY, Lee SI

OBJECTIVE: Angiopoietin-1 (Ang1) is a potent angiogenic factor that can increase synovial angiogenesis and also enhance osteoblast maturation and bone formation. However, its role in rheumatoid arthritis (RA) has not...
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Angiopoietin-1 Gene Therapy Attenuates Hypertension and Target Organ Damage in Nitric Oxide Synthase Inhibited Spontaneously Hypertensive Rats

Suh W, Lee JS, Kim KL, Song SH, Koh GY, Kim DK

BACKGROUND AND OBJECTIVES: In our previous study, we found that the gene transfer of a potent derivative of cartilage oligomeric matrix protein Angiopoietin-1 (COMP-Ang-1) substantially prevented hypertension, microvascular rarefaction, and...
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Angiopoietin-1 Protects Endothelial Cells From Hypoxia-Induced Apoptosis via Inhibition of Phosphatase and Tensin Homologue Deleted From Chromosome Ten

Lee SW, Youn SW, Kim TY, Suh JW, Koh GY, Kwon YW, Chae IH, Park YB, Kim HS

BACKGROUND AND OBJECTIVES: Angiopoietin-1 (Ang1) is a regulator of blood vessel growth and maturation, and prevents radiation-induced or serum deprivation-induced apoptosis. Phosphatase and tensin homologue deleted from chromosome ten (PTEN),...
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Activation of PPARgamma induces profound multilocularization of adipocytes in adult mouse white adipose tissues

Koh YJ, Park BH, Park JH, Han J, Lee IK, Park JW, Koh GY

We sought to determine the effects of activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male C57BL/6 normal, db/db, and ob/ob mice...
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COMP-angiopoietin 1 Gene Transfer Enhances Cutaneous Wound Healing by Promoting Angiogenesis

Kim YY, Kim YJ, Ku JK, Kim MY, Kim YI, Koh GY, Kim HO, Park YM

BACKGROUND: Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered...
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Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury

Kim SR, Lee KS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Koh GY, Lee YC

Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability, and plasma exudation are cardinal features of acute lung injury. Angiopoietin-1 (Ang1)...
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Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1

Lee KS, Lee KY, Kim SR, Park HS, Park SJ, Min KH, Cho CH, Koh GY, Park HS, Lee YC

  • KMID: 1091068
  • Exp Mol Med.
  • 2007 Dec;39(6):733-745.
Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage. Recently, we developed a soluble,...
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Relationship of Angiopoietin-2 Expression to Atherosclerosis in Middle Cerebral and Coronary Arteries

Shin EK, Park JW, Park MC, Kim CW, Ahn JS, Park KH, Kim DJ, Hahn JH, Koh GY, Park JH

  • KMID: 1510193
  • Korean J Anat.
  • 2006 Aug;39(4):269-278.
Atherosclerosis is a systemic and multifactorial disease, its incidence is raised recently. Cerebral and coronary atherosclerosis have some similar pathogenesis, but their relationship and mechanisms are still remain unclear. Intimal neovascularization in...
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Pathophysiological Role of Angiopoietin-2 in Human Coronary Atherosclerosis

Shin EK, Park MC, Lee JH, Kim DJ, Hahn JH, Park KH, Koh GY, Park JH

  • KMID: 1564364
  • Korean J Anat.
  • 2005 Aug;38(4):295-306.
Neovascularization is well known to occur in human atherosclerotic plaques; however, its pathophysiological roles, mechanism, and stimuli still remain unclear. Angiopoietin-1 and -2 belong to another vascular-specific growth factor family...
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The Antiapoptotic Effect of Vascular Endothelial Growth Factor and Angiopoietin-1 on Glomerular Endothelial Cells in Adriamycin or Cisplatin-induced Apoptosis

Kim W, Lim CS, Sung MJ, Kim SH, Moon SO, Lee S, La BJ, Park SK, Kang SK, Kim HJ, Koh GY

  • KMID: 2254393
  • Korean J Nephrol.
  • 2002 Jul;21(4):569-583.
BACKGROUND: Because glomerular endothelium play a pivotal role in the renal diseases, damage of glomerular endothelial cells lead to progression of glomerular sclerosis and decrement of renal function. Apoptotic damage...
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Expressions of Angiopoietins-1 and -2 and their Relations with the Stage in Gastric Adenocarcinoma

Lee WS, Choi SK, Rew JS, Kim SJ, Kim YJ, Park CS, Koh GY, Choi C

  • KMID: 2085015
  • Korean J Gastroenterol.
  • 2002 May;39(5):335-342.
No abstract available.
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Biomedical significance of endothelial cell specific growth factor, angiopoietin

Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC

  • KMID: 1093591
  • Exp Mol Med.
  • 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth...
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Angiogenic Factors and Their Receptors

Koh GY

  • KMID: 1568684
  • J Korean Soc Endocrinol.
  • 2001 Jun;16(3):277-283.
No abstract available.
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Gene Ploymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase in Patients with IgA Nephropathy

Kim IH, Kim W, Kang SK, Lee DY, Koh GY, Lee KY, Park SB, Kim HC, Park SK

  • KMID: 2307327
  • Korean J Nephrol.
  • 1999 May;18(3):390-399.
To evaluate the association between ACE gene I/D polymorphism and ecNOS gene a/b polymorphism in IgA nephropathy, 158 IgA nephropathy patients and 121 control subjects were examined. In genotype...
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Alteration of Insulin-like Growth Factor ( IGF ) -I and IGP-Binding Proteins in Renal Development and Regeneration

Lee DY, Park SK, Koh GY

  • KMID: 2001746
  • J Korean Soc Pediatr Nephrol.
  • 1999 Oct;3(2):109-116.
The effect of Roentgen rays on carcinoma of the cervix has long been of great interest to both radiologists and gynecologists. Since most cervical carcinomas are treated by irradiation, any...
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The Synthesis and Distribution of TGF-beta1 in Cardiac Valves

Ko JK, Kim NG, Kim MH, Chae JK, Koh GY

BACKGROUND AND OBJECTIVES: Transforming growth factor-beta1 (TGF-beta1) plays an important role on cardiac muscle differentiation, cardiac septa and valve formation during heart development. However, the role of TGF-beta1 in cardiac...
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Cell cycle regulators during human atrial development

Kim WH, Joo CU, Ku JH, Ryu CH, Koh KN, Koh GY, Ko JK

  • KMID: 759076
  • Korean J Intern Med.
  • 1998 Jul;13(2):77-82.
OBJECTIVES: The molecular mechanisms that regulate cardiomyocyte cell cycle and terminal differentiation in humans remain largely unknown. To determine which cyclins, cyclin dependent kinases (CDKs) and cyclin kinase inhibitors (CKIs)...
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Angiotensin Converting Enzyme Gene Polymorphism in Patients with Minimal Change Nephrotic Syndrome and Focal Segmental Glomerulosclerosis

Kim W, Park SK, Kang SK, Koh GY, Song SK, Lee KY, Chung WY, Kim PK, Lee DY

  • KMID: 2254668
  • Korean J Nephrol.
  • 1998 Mar;17(2):208-213.
Angiotensin converting enzyme gene insertion/ deletion polymorphism has been shown to be associated with cardiovascular disease including cardiomyopathy, myocardial infarction, essential hypertension, progression of IgA nephropathy and diabetic nephropathy. Since...
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