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Systemically administered neurotensin receptor agonist produces antinociception through activation of spinally projecting serotonergic neurons in the rostral ventromedial medulla

Li Y, Kang DH, Kim WM, Lee HG, Kim SH, You HE, Choi JI, Yoon MH

Background: Supraspinal delivery of neurotensin (NTS), which may contribute to the effect of a systemically administered agonist, has been reported to be either pronociceptive or antinociceptive. Here, we evaluated the...
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Prostaglandin D2 contributes to cisplatin-induced neuropathic pain in rats via DP2 receptor in the spinal cord

Li Y, Kim WM, Kim SH, You HE, Kang DH, Lee HG, Choi JI, Yoon MH

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed...
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The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain

Kim DY, Chae JW, Lim CH, Heo BH, Park KS, Lee HG, Choi JI, Yoon MH, Kim WM

BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action....
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Comparison of effects of intraoperative nefopam and ketamine infusion on managing postoperative pain after laparoscopic cholecystectomy administered remifentanil

Choi SK, Yoon MH, Choi JI, Kim WM, Heo BH, Park KS, Song JA

BACKGROUND: Although intraoperative opioids provide more comfortable anesthesia and reduce the use of postoperative analgesics, it may cause opioid induced hyperalgesia (OIH). OIH is an increased pain response to opioids...
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Chronic pelvic pain arising from dysfunctional stabilizing muscles of the hip joint and pelvis

Lee DW, Lim CH, Han JY, Kim WM

Chronic pelvic pain in women is a very annoying condition that is responsible for substantial suffering and medical expense. But dealing with this pain can be tough, because there are...
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A Comparative Efficacy of Propacetamol and Ketorolac in Postoperative Patient Controlled Analgesia

Heo BH, Park JH, Choi JI, Kim WM, Lee HG, Cho SY, Yoon MH

BACKGROUND: Ketorolac has been used as a postoperative analgesia in combination with opioids. However, the use of ketorolac may produce serious side effects in vulnerable patients. Propacetamol is known to...
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Corrigendum: Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats (Korean J Anesthesiol 2015 April 68(2): 170-174)

Cho SY, Ki HG, Kim JM, Oh JM, Yang JH, Kim WM, Lee HG, Yoon MH, Choi JI

This article was inadvertently omitted Acknowledgments section for grant support.
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Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase

Park AR, Kim WM, Heo BH

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence...
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Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats

Cho SY, Ki HG, Kim JM, Oh JM, Yang JH, Kim WM, Lee HG, Yoon MH, Choi JI

BACKGROUND: Although the inhibitory role of the 5-hydroxytrypatmine receptor 7(5-HT7R) on nociceptive processing is generally recognized, an excitatory effect associated with a reduced 5-HT7R expression has also been observed in...
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Hyperintensity of Subarachnoid Space on FLAIR Images Caused by Supplemental Oxygen

Choi YJ, Lee SH, Bae CB, Park JY, Kim WM, Oh BC

  • KMID: 1775108
  • J Korean Neurol Assoc.
  • 2015 Feb;33(1):26-28.
A hyperintensity in the subarachnoid space on fluid-attenuated inversion-recovery (FLAIR) images is often caused by diseases such as subarachnoid hemorrhage or meningitis. Oxygen has a known paramagnetic effect and also...
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Lemierre's Syndrome Presenting with Atypical Features

Bae CB, Choi YJ, Lee SH, Park JY, Kim WM, Oh BC

  • KMID: 1775107
  • J Korean Neurol Assoc.
  • 2015 Feb;33(1):21-25.
Lemierre's syndrome is characterized by anaerobic bacterial infection in the head and neck, causing thrombophlebitis of the jugular vein. This disease is usually associated with a history of pharyngitis. The...
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Epidural Infusion of Morphine and Levobupivacaine through a Subcutaneous Port for Cancer Pain Management

Heo BH, Pyeon TH, Lee HG, Kim WM, Choi JI, Yoon MH

BACKGROUND: To manage intractable cancer pain, an alternative to systemic analgesics is neuraxial analgesia. In long-term treatment, intrathecal administration could provide a more satisfactory pain relief with lower doses of...
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Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test

Jeong SH, Heo BH, Park SH, Kim WM, Lee HG, Yoon MH, Choi JI

BACKGROUND: Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic...
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Dexmedetomidine for sedation of patients undergoing elective surgery under regional anesthesia

Song J, Kim WM, Lee SH, Yoon MH

BACKGROUND: Dexmedetomidine may be useful as a sedative agent. However, it has been reported that dexmedetomidine decreases systemic blood pressure, heart rate, and cardiac output in a dose-dependent manner. The...
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A Case of Left Coronary Artery Milking Treated by Direct Stenting During Percutaneous Coronary Intervention in A Patient with Unstable Angina

Lee SH, Lee KO, Kim WM, Baek HE, Lee SU, Kang DG, Cho SK

  • KMID: 2082466
  • Korean J Med.
  • 2013 Apr;84(4):572-576.
Coronary artery milking is defined as a systolic compression of the coronary artery, usually resulting from myocardial bridging. Rarely, congenital heart disease, pulmonary hypertension and ventricular aneurysm can lead to...
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Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain

Lee HG, Kim WM, Yoon MH, Park AR, Choi JI

BACKGROUND: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which...
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Antinociceptive Effect of Intrathecal Nefopam and Interaction with Morphine in Formalin-Induced Pain of Rats

Cho SY, Park AR, Yoon MH, Lee HG, Kim WM, Choi JI

BACKGROUND: Nefopam, a non-opiate analgesic, has been regarded as a substance that reduces the requirement for morphine, but conflicting results have also been reported. The inhibition of monoamine reuptake is...
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Spinal Cord Stimulation for Refractory Angina Pectoris: A Case Report

Lee SH, Jeong HJ, Jeong SH, Lee HG, Choi JI, Yoon MH, Kim WM

Refractory angina pectoris is defined as angina refractory to optimal medical treatment and standard coronary revascularization procedures. Despite recent therapeutic advances, patients with refractory angina pectoris are not adequately treated....
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Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test

Han YK, Lee SH, Jeong HJ, Kim MS, Yoon MH, Kim WM

BACKGROUND: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model...
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Cardiovascular and arousal responses to single-lumen endotracheal and double-lumen endobronchial intubation in the normotensive and hypertensive elderly

Yoo KY, Jeong CW, Kim WM, Lee HK, Jeong S, Kim SJ, Bae HB, Lim DY, Chung SS

BACKGROUND: Endotracheal intubation usually causes transient hypertension and tachycardia. The cardiovascular and arousal responses to endotracheal and endobronchial intubation were determined during rapid-sequence induction of anesthesia in normotensive and hypertensive...
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