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Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodendroglial Tumors

Jeong HJ, Woo CG, Lee B, Khang SK, Nam SJ, Choi J

BACKGROUND: Protein phosphatase magnesium-dependent 1δ (PPM1D) is a p53-induced serine/threonine phosphatase, which is overexpressed in various human cancers. A recent study reported that a mutation in the PPM1D gene is...
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High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients

Cho SY, Park C, Na D, Han JY, Lee J, Park OK, Zhang C, Sung CO, Moon HE, Kim Y, Kim JH, Kim JJ, Khang SK, Nam DH, Choi JW, Suh YL, Kim DG, Park SH, Youn H, Yun K, Kim JI, Lee C, Paek SH, Park H

Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because of its poor prognosis and limited genomic information. To gain a comprehensive view of...
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Diagnostic Significance of Cellular Neuroglial Tissue in Ovarian Immature Teratoma

Chai Y, Woo CG, Kim JY, Kim CJ, Khang SK, Kim J, Park IA, Kim EN, Kim KR

BACKGROUND: Immature teratoma (IT) is a tumor containing immature neuroectodermal tissue, primarily in the form of neuroepithelial tubules. However, the diagnosis of tumors containing only cellular neuroglial tissue (CNT) without...
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Giant hypothalamic hamartoma associated with an intracranial cyst in a newborn

Lee JY, Yoon HK, Khang SK

We report the case of a giant hypothalamic hamartoma with a large intracranial cyst in a neonate. On ultrasonography, the lesion presented as a lobulated, mass-like lesion with similar echogenicity...
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Primary Histiocytic Sarcoma of the Central Nervous System

So H, Kim SA, Yoon DH, Khang SK, Hwang J, Suh CH, Suh C

Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS...
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Upfront Stereotactic Radiosurgery for Pineal Parenchymal Tumors in Adults

Park JH, Kim JH, Kwon DH, Kim CJ, Khang SK, Cho YH

OBJECTIVE: Pineal parenchymal tumors (PPTs) in adults are rare, and knowledge regarding their optimal management and treatment outcome is limited. Herein, we present the clinical results of our series of...
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Significant Symptom Relief with Hepatic Artery Embolization in a VIPoma with Liver Metastases

Choi YS, Ko GY, Ryu MH, Khang SK, Kim JE, Song JS, Kang YK

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) cause VIPoma syndrome, which is characterized by watery diarrhea, hypokalemia, and achlorhydria. The treatment options for metastatic VIPomas include somatostatin analogs, cytoreductive surgery, and chemotherapy....
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Intramedullary Spinal Cysticercosis: A Case Report and Review of Literature

Kim M, Rhim SC, Khang SK

To report a case of spinal intramedullary cysticercosis in thoracic spine. A 47-year old man living in Korea referred to our hospital with both feet tingling sensation for about a...
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Cytological Evaluation and REBA HPV-ID HPV Testing of Newly Developed Liquid-Based Cytology, EASYPREP: Comparison with SurePath

Lee YS, Gong G, Sohn JH, Ryu KS, Lee JH, Khang SK, Cho KJ, Kim YM, Kang CS

  • KMID: 2277444
  • Korean J Pathol.
  • 2013 Jun;47(3):265-274.
BACKGROUND: The objective of this study was to evaluate a newly-developed EASYPREP liquid-based cytology method in cervicovaginal specimens and compare it with SurePath. METHODS: Cervicovaginal specimens were prospectively collected from 1,000...
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Epidural Cavernous Hemangioma with Foraminal Extension

Ha JG, Bae CW, Khang SK, Rhim SC

The increased use of magnetic resonance imaging (MRI) has increased the frequency of diagnosis of cavernous hemangioma, but its presentation of an epidural lesion with foraminal extension without intramedullary involvement...
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Intracranial Fibromatosis: A Case Report

Lee JJ, Kim JH, Khang SK, Cho KJ, Kim J

Fibromatosis can occur at various sites, but intracranial fibromatosis is exceptionally rare. Here, we report a case of intracranial fibromatosis arising in the suprasellar area of a 52-year-old woman who...
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Neoplastic Stromal Cells of Intracranial Hemangioblastomas Disclose Pericyte-derived Mesenchymal Stromal Cells-like Phenotype

Jung YH, Kim J, Kim BM, Kim EK, Kang MS, Jung S, Yang YI, Khang SK

  • KMID: 1979058
  • Korean J Pathol.
  • 2011 Dec;45(6):564-572.
BACKGROUND: Stromal cells (SCs) of hemangioblastomas (HBs) have been regarded as true neoplastic components, but their ontogeny remains unclear. Convincing evidence suggests that embryonic mesenchymal cells may be the cells...
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Intradural Involvement of Multicentric Myxoid Liposarcoma

Cho SH, Rhim SC, Hyun SJ, Bae CW, Khang SK

Liposarcomas are malignant tumors of the soft tissue, with myxoid liposarcoma being the second most common subtype, tending to occur in the limbs, particularly in the thighs. Myxoid liposarcomas have...
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Two Cases of Pheochromocytoma Presented with Hypertension and Weight Loss

Kim YM, Jin HY, Khang SK, Kim KR, Lee SR, Choi JH, Yoo HW

  • KMID: 1462874
  • J Korean Soc Pediatr Endocrinol.
  • 2010 Aug;15(2):145-149.
Pheochromocytoma is a rare disease in children, arising from chromaffin cells of adrenal medullary or extra-adrenal paraganglionic tissues. Typical clinical features include hypertension, diaphoresis, headache, and weight loss. It should...
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Lyn Expression in Osteoblastic Osteosarcoma Tissues and Its Correlation with Clinicopathologic Factors

Jin MS, Khang SK, Kim MS, Choi HS, Lee JE, Kim KH, Jeon DG, Koh JS

  • KMID: 2277600
  • Korean J Pathol.
  • 2010 Apr;44(2):125-131.
BACKGROUND: The Src family kinases (SFKs) are involved in multiple aspects of tumorigenesis, such as, proliferation, migration, and angiogenesis, and are involved in the generation and progression of many types...
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The Significance of Immunohistochemical Staining, Including that for Glucose Transporter Protein Isoform 1, as Related to the Clinical and Angiographic Features of Adult Soft-Tissue Hemangioma and Arteriovenous Malformation in the Head and Neck

Lee HY, Kim SM, Choi JW, In HS, Cho KJ, Cha EY, Hwang JE, Khang SK, Nam SY, Kim SY, Lee BJ, Lee JH, Suh DC

PURPOSE: Glucose transporter protein isoform 1 (GLUT1) has been introduced to diagnose the hemangiomas of infancy. We investigated the usefulness of several immunohistochemical markers, including GLUT1, as related with the...
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Tuberculous Meningoencephalitis Complicated by Subarachnoid Hemorrhage

Kim SM, Lee E, Kim BJ, Kim JH, Khang SK, Kim JS, Kang JK

  • KMID: 2191927
  • J Korean Neurol Assoc.
  • 2009 Nov;27(4):409-412.
Tuberculous meningoencephalitis (TBM) is often complicated by various neurologic manifestations including ischemic infarctions. However, intracerebral hemorrhage in TBM has rarely been described. We report a 30-year-old woman with TBM who...
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Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women

Choi G, Kim JW, Khang SK, Kim KR

BACKGROUND: Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed. METHODS: We investigated clinicopathologic characteristics of endometrial carcinoma in 48...
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Second Opinion Diagnoses of Cytologic Specimens on Consultation : Asan Medical Center Experience

Park S, Ro JY, Cho KJ, Gong G, Cho YM, Khang SK

BACKGROUND: Second opinion diagnosis of outside pathology slides is a common practice for efficient and proper patient management. We analyzed cytology slides from outside hospitals submitted for a second opinion...
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Quality Control Program and Its Results of Korean Society for Cytopathologists

Lee HK, Kim SN, Khang SK, Kang CS, Yoon HK

In Korea, the quality control(QC) program forcytopathology was introduced in 1995. The program consists of a checklist for the cytolopathology departments, analysis data on all the participating institutions' QC data,...
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