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Cell Autonomous Circadian Systems and Their Relation to Inflammation

Annamneedi VP, Park JW, Lee GS, Kang TJ

All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN)...
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Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis

Prakash AV, Park JW, Seong JW, Kang TJ

The process of drug discovery and drug development consumes billions of dollars to bring a new drug to the market. Drug development is time consuming and sometimes, the failure rates...
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Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4⁺CD25⁺FoxP3⁺ Regulatory T-Cells and Induced by TGF-β1 and IL-10

Hong JW, Lim JH, Chung CJ, Kang TJ, Kim TY, Kim YS, Roh TS, Lew DH

PURPOSE: Most studies on immune tolerance of mesenchymal stem cells (MSCs) have been performed using MSCs derived from bone marrow, cord blood, or adipose tissue. MSCs also exist in the...
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Rifampicin Alleviates Atopic Dermatitis-Like Response in vivo and in vitro

Kim SH, Lee KM, Lee GS, Seong JW, Kang TJ

Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it...
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Chitin from Cuttlebone Activates Inflammatory Cells to Enhance the Cell Migration

Lim SC, Lee KM, Kang TJ

Our previous report showed that the extract from cuttlebone (CB) had wound healing effect in burned lesion of rat and the extract was identified as chitin by HPLS analysis. We...
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Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae

Kim TH, Chae GT, Kang TJ

The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense against bacterial infection. To study the role of NODs in the host response to Mycobacterium leprae, we measured...
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Investigation of anodized titanium implants coated with triterpenoids extracted from black cohosh: an animal study

Park IP, Kang TJ, Heo SJ, Koak JY, Kim JH, Lee JH, Lee SJ, Kim SK

PURPOSE: The purpose of this study was to evaluate bone response to anodized titanium implants coated with the extract of black cohosh, Asarum Sieboldii, and pharbitis semen. MATERIALS AND METHODS: Forty...
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Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression

Lee KM, Shim H, Lee GS, Park IH, Lee OS, Lim SC, Kang TJ

  • KMID: 1502495
  • Biomol Ther.
  • 2013 May;21(3):246-250.
We previously reported that the extract from cuttlebone (CB) has wound healing effect in burned lesion of rat. In present study, the main component of CB extract was analyzed and...
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Mega Fat Graft for Breast Augmentation

Kang TJ

  • KMID: 2167572
  • Arch Aesthetic Plast Surg.
  • 2012 Jun;18(2):75-80.
After numerous experiments with free-fat transfer since 1893, many promising methods and results of large-volume fat graft have been published recently. A common disadvantage was the time of the procedure...
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The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model

Lee GS, Shim H, Lee KM, Kim SH, Yim D, Cheong JH, Kang TJ

We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated...
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Polyacetylene Compound from Cirsium japonicum var. ussuriense Inhibited Caspase-1-mediated IL-1beta Expression

Shim H, Moon JS, Lee S, Yim D, Kang TJ

Our previous report showed that polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense has anti-inflammatory activity. In this study we investigated the role...
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The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae

Kang TJ, Chae GT

The nucleotide-oligomerization domain (NOD) proteins are members of the NOD-like receptor (NLR) family, which are intracellular and cytoplasmic receptors. We analyzed the role of NODs for cytokine production by macrophages...
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Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis

Kang TJ, Jin SH, Yeum CE, Lee SB, Kim CH, Lee SH, Kim KH, Shin ES, Chae GT

BACKGROUND: The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to activation of macrophages and deficiency of vitamin D seems to be involved in the risk of tuberculosis. The...
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A Modified MACS Lift Combined with Composite Flap Elevation

Kang TJ, Tark KC, Shin WJ, Park YJ

  • KMID: 784036
  • J Korean Soc Aesthetic Plast Surg.
  • 2009 Mar;15(1):41-47.
Composite face lift has been accepted as the best technique for getting satisfactory outcome in surgical rejuvenation. As operations that ensure fast recovery and minimal complication were favored, MACS lift...
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Treatments of Phyllodes Tumor in Breast and Immediate Breast Reconstruction

Kang TJ, Kim YS, Roh TS, Yoo WM, Tark KC, Jeong J

  • KMID: 2203148
  • J Korean Soc Plast Reconstr Surg.
  • 2008 Sep;35(5):539-544.
PURPOSE: There have been limited reports on breast reconstruction after excision of phyllodes tumor. This paper reports four patients who had immediate reconstruction of the breast following excision of phyllodes...
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Clinical Application of Maggots in Chronic Difficult Wounds

Kim SW, Kang TJ

  • KMID: 2322408
  • J Korean Soc Plast Reconstr Surg.
  • 2008 Jul;35(4):400-406.
PURPOSE: Since ancient times, larval therapy has been applied to help wound healing. Its use has recently been rediscovered, and the interest in this therapy has been increased in clinical...
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Long-term Outcome of Endopyelotomy for the Treatment of Ureteropelvic Junction Obstruction

Doo C, Kang TJ, Park SC, Hong B, Park HK, Park T

  • KMID: 2294032
  • Korean J Urol.
  • 2005 Aug;46(8):829-834.
Purpose: The treatment outcome of endopyelotomy is now being re-evaluated in the era of laparoscopic pyeloplasty. This study was performed to evaluate the long-term success rate of an endopyelotomy for...
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Comparison of rpoT gene of M. leprae strain from korean and foreign leprosy patients

Kang TJ, Kim SK, Kim NH, Matsuoka M, Chae GT

  • KMID: 1993560
  • Korean Lepr Bull.
  • 2004 Jul;37(1):3-14.
The variance of tandem repeats in the rpoT gene of Mycobacterium leprae was recently demonstrated. The objects of this study was to examine the proportion and distributions of the genotypes...
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Expression of Bcl-2 and Bax in cis-Diamminedichloroplatinum (II)-Resistant Bladder Cancer Cell Lines

Song C, Kang TJ, You DS, Hong JH, Ahn HJ

  • KMID: 2293492
  • Korean J Urol.
  • 2004 May;45(5):472-477.
PURPOSE: Development of drug resistance has been the major obstacle in cis-Diamminedichloroplatinum (II) (cisplatin)-based combination chemotherapy in the treatment of advanced bladder cancer for which a variety of mechanisms has...
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Detection of point mutation at C-terminal region of phagosomal coat protein (TACO) in patients with leprosy

Kim SK, Kang TJ, Kim BC, Chae GT

  • KMID: 1516979
  • Korean Lepr Bull.
  • 2003 Jul;36(1):11-26.
Mycobacteria, which are highly successful pathogen, resist delivary to lysosomes and instead survive within a specialized vacuole, the mycobacterial phagosome. The bacteria survive intracellularly because they are able to actively...
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