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Deficiencies of Homer2 and Homer3 accelerate aging-dependent bone loss in mice

Kang JY, Kang N, Shin DM, Yang YM

Homer proteins are scaffold proteins that regulate calcium (Ca2+) signaling by modulating the activity of multiple Ca2+ signaling proteins. In our previous report, Homer2 and Homer3 regulated NFATc1 function through...
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Decrease of protein phosphatase 2A subunit B by glutamate exposure in the cerebral cortex of neonatal rats

Kang JB, Park DJ, Son HK, Koh PO

Glutamate induces neurotoxicity during brain development, causing nerve damage. Protein phosphatase 2A (PP2A) is a type of serine/threonine phosphatase that regulates various biological functions. Among the PP2A subunit types, subunit...
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Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice

Shah MA, Park DJ, Kang JB, Koh PO, Kim MO

Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS) is an endotoxin that releases inflammatory cytokines and induces inflammatory response....
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Evaluation of the clinical efficacy of a TW3-based fully automated bone age assessment system using deep neural networks

Shin NY, Lee BD, Kang JH, Kim HR, Oh DH, Lee BI, Kim SH, Lee MS, Heo MS

Purpose: The aim of this study was to evaluate the clinical efficacy of a Tanner-Whitehouse 3 (TW3)-based fully automated bone age assessment system on hand-wrist radiographs of Korean children and...
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Clinical Practice Guideline for Care in the Last Days of Life

Shin J, Chang YJ, Park SJ, Choi JY, Kim SH, Choi YS, Kim NH, Yum HK, Nam EM, Park MH, Moon N, Moon JY, Kang HT, Kang JH, Park JM, Lee CW, Kim SY, Lee EJ, Koh SJ, Kim Y, Agnes Cho M, Song Y, Shim JY

A clinical practice guideline for patients in the dying process in general wards and their families, developed through an evidence-based process, is presented herein. The purpose of this guideline is...
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Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress

Kang JM, Lee HS, Kim J, Yang DH, Jeong HY, Lee YH, Kim DJ, Park SH, Sung M, Kim J, An HJ, Lee SH, Lee SY

Background: Oxidative stress induced by chronic hyperglycemia is recognized as a significant mechanistic contributor to the development of diabetic kidney disease (DKD). Nonphagocytic nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) is...
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Factors Affecting Use of Personal Protective Equipment related to Acute Respiratory Infections in General Hospital Nurses

Kang J, Kim J

Purpose: The purpose of this research was to identify the risk perception of acute respiratory infections, safety climate and the use of personal protective equipment, and to verify the factors...
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Analysis of HIV RNA Genotypes and Quantitative Values of HIV NAT Reactive Blood Donations

Kang Jw, Kang Jw, Ko DH, Youn M, Kwon SY

Background: The Korean Red Cross adopted HIV NAT for blood donor screening in 2005 using a minipool assay. In June 2012, the NAT system was replaced with the individual assay....
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Bertolotti’s Syndrome Requiring Intervention for Lower Back Pain: Two Cases Suspected as Ankylosing Spondylitis

Kang J, Lee S, Kim TH

Bertolotti’s syndrome is the part of lumbosacral transitional vertebra and is a congenital anomaly of the axial spine. The syndrome is associated with changes in the sacrum or iliac crest...
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Effect of Sarcopenia and Body Shape on Cardiovascular Disease According to Obesity Phenotypes

Cho HW, Chung W, Moon S, Ryu OH, Kim MK, Kang JG

Background: This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according to obesity phenotypes. Methods: We used data from the...
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Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Kang JI, Choi YK, Koh YS, Hyun JW, Kang JH, Lee KS, Lee CM, Yoo ES, Kang HK

The hair cycle (anagen, catagen, and telogen) is regulated by the interaction between mesenchymal cells and epithelial cells in the hair follicles. The proliferation of dermal papilla cells (DPCs), mesenchymal-derived...
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Emotional Changes and Protective Factors of Emotional Workers in the Public and Private Sector

Lee J, Han C, Ko YH, Kang J, Byun Y, Son Y, Yoon HK

Objective Emotional labor is known to be a risk factor for emotional distress. This study aimed to evaluate specific stressors according to the type of occupation and identify protective and...
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Choosing Wisely: The Korean Perspective and Launch of the ‘Right Decision in Cancer Care’ Initiative

Kim JY, Lee KE, Kim K, Lee MA, Yoon WS, Han DS, Ahn SG, Kang JH

Government healthcare expenditure is rising in Korea, and the costs incurred by patients in Korea exceed those incurred by patients in other Organization for Economic Co-operation and Development countries. Despite...
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Clinical study of colorectal cancer operation: Survival analysis

Hong Y, Kim J, Choi YJ, Kang JG

Purpose: Overall 5-year survival rates for colon and rectal cancer reported recently by the American Cancer Society were 89%, 90% for localized disease, 71%, 71% for regional disease, and 14%,...
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Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells

Kang N, Kang JY, Shin DM, Yang YM

The salivary glands secrete saliva, which plays a role in the maintenance of a healthy oral environment. Under physiological conditions, saliva secretion within the acinar cells of the gland is...
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Radioisotope-ADME studies of Trastuzumab-monomethyl auristatin F in tumor bearing mice and healthy marmosets

Lee HW, Jeong YH, Hwang JA, Lee JJ, Yu AR, Kang JA, Raza MA, Park SH, Park YH, Kim DH

Radioisotope ADME (RI-ADME) studies are enabling visualization of the biodistribution in molecular imaging. We applied RI-ADME to investigate the tumor targeting capacity and biodistribution of trastuzumab-monomethyl auristatin F (LCB14-0110) in...
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The Effect of Reform of New Diagnosis-Related Groups on Coverage of National Health Insurance

Choi JK, Kim SH, Chang CH, Yoon JM, Kang JG

Background: Korea set up a new diagnosis-related group as a demonstration project in 2009. The new diagnosis-related group was reformed in 2016. The main purpose of the study is to...
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Management of Urinary Incontinence With Underactive Bladder: A Review

Cho KJ, Kim JC

Urinary incontinence is caused by storage function failure, while underactive bladder (UAB) is caused by a decline in detrusor contractility and voiding dysfunction. As the treatment mechanisms for incontinence and...
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Relationships between Thigh and Waist Circumference, Hemoglobin Glycation Index, and Carotid Plaque in Patients with Type 2 Diabetes

Yoon MK, Kang JG, Lee SJ, Ihm SH, Huh KB, Kim CS

Background: This study investigated the relationships of thigh and waist circumference with the hemoglobin glycation index (HGI) and carotid atherosclerosis in patients with type 2 diabetes. Methods: This observational study included...
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Decrease of 14–3-3 proteins by glutamate exposure in the cerebral cortex of newborn rats

Kang JB, Lee SY, Park DJ, Koh PO

Glutamate is a representative excitatory neurotransmitter. However, excessive glutamate exposure causes neuronal cell damage by generating neuronal excitotoxicity. Excitotoxicity in neonates caused by glutamate treatment induces neurological deficits in adults....
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