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Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

Choi YK, Kang JI, Hyun JW, Koh YS, Kang JH, Hyun CG, Yoon KS, Lee KS, Lee CM, Kim TY, Yoo ES, Kang HK

Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles...
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Development and Evaluation of Portable Self-Respiratory Training System Using Patch Type Magnetic Sensor

Kang HK, Kim JS, Kim Dw

  • KMID: 2510093
  • Prog Med Phys.
  • 2020 Sep;31(S1):S51.
Purpose: An anatomic motion of organs and tumors due to breathing increases the internal margin in radiation therapy, which increases the uncertainty of treatment. Many studies have been conducted for...
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Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

Kang JI, Choi YK, Koh YS, Hyun JW, Kang JH, Lee KS, Lee CM, Yoo ES, Kang HK

The hair cycle (anagen, catagen, and telogen) is regulated by the interaction between mesenchymal cells and epithelial cells in the hair follicles. The proliferation of dermal papilla cells (DPCs), mesenchymal-derived...
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The Use of Inappropriate Antibiotics in Patients Admitted to Intensive Care Units with Nursing Home–Acquired Pneumonia at a Korean Teaching Hospital

Kim DH, Kim HJ, Koo HW, Bae W, Park SH, Koo HK, Park HK, Lee SS, Kang HK

BACKGROUND: Use of appropriate antibiotics for the treatment of pneumonia is integral in patients admitted to intensive care units (ICUs). Although it is recommended that empirical treatment regimens should be...
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Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5

Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, Hyun JW

Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis...
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Current Status of Noninvasive Ventilation Use in Korean Intensive Care Units: A Prospective Multicenter Observational Study

Nam H, Cho JH, Choi EY, Chang Y, Choi WI, Hwang JJ, Moon JY, Lee K, Kim SW, Kang HK, Sim YS, Park TS, Park SY, Park S, on behalf of Korean NIV Study Group

BACKGROUND: Data on noninvasive ventilation (NIV) use in intensive care units (ICUs) are very limited in South Korea. METHODS: A prospective observational study was performed in 20 ICUs of university-affiliated hospitals...
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Esculetin Prevents the Induction of Matrix Metalloproteinase-1 by Hydrogen Peroxide in Skin Keratinocytes

Zhen AX, Piao MJ, Kang KA, Fernando P, Kang HK, Koh YS, Hyun JW

BACKGROUND: Reactive oxygen species (ROS) are involved in various cellular diseases. Excessive ROS can cause intracellular oxidative stress, resulting in a calcium imbalance and even aging. In this study, we...
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Prognostic Value of Procalcitonin in Pneumonia among Patients Admitted to Intensive Care Unit.

Kim DH, Jung HW, Kang HK

OBJECTIVES: Pneumonia is one of the leading causes of death in the intensive care unit (ICU). Many biomarkers for predicted prognosis have been suggested; among these, procalcitonin (PCT) is known...
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Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter

Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW

Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that...
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7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress

Cho SJ, Kang KA, Piao MJ, Ryu YS, Fernando P, Zhen AX, Hyun YJ, Ahn MJ, Kang HK, Hyun JW

Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent...
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The Prevalence and Characterization of Cerebral Microbleeds in Young People Having Intracerebral Hemorrhage

Lee YM, Koo HW, Kang HK, Kim JW, Han SR, Yoon SW, Choi CY, Sohn MJ, Lee CH

OBJECTIVE: Cerebral microbleeds (CMBs) are known as the neuroimaging markers of risk in stroke and dementia. Many studies on CMBs in elderly patients with hemorrhagic or ischemic stroke have been...
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4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

Kim SC, Kang JI, Hyun JW, Kang JH, Koh YS, Kim YH, Kim KH, Ko JH, Yoo ES, Kang HK

4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-β (TGF-β) signal pathway has an...
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Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease

Koo HK, Kang HK, Song P, Park HK, Lee SS, Jung H

BACKGROUND: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory...
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Effect of Gadoxetic Acid on Quantification of Hepatic Steatosis Using Magnetic Resonance Spectroscopy: A Prospective Study

Kim JW, Kim SM, Heo SH, Kim JW, Shin SS, Jeong YY, Jeong GW, Kang HK

PURPOSE: We prospectively evaluated whether gadoxetic acid (Gd-EOB-DTPA) administration for liver magnetic resonance (MR) imaging affects the quantification of hepatic steatosis using MR spectroscopy (MRS). MATERIALS AND METHODS: A total of...
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The Use of Lung Ultrasound in a Surgical Intensive Care Unit

Kang HK, So HJ, Kim DH, Koo HK, Park HK, Lee SS, Jung H

BACKGROUND: Pulmonary complications including pneumonia and pulmonary edema frequently develop in critically ill surgical patients. Lung ultrasound (LUS) is increasingly used as a powerful diagnostic tool for pulmonary complications. The...
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Comparative Study of Ultrasonography, Computed Tomography, Magnetic Resonance Imaging, and Magnetic Resonance Spectroscopy for the Diagnosis of Fatty Liver in a Rat Model

Noh H, Song XL, Heo SH, Kim JW, Shin SS, Ahn KY, Jeong YY, Kang HK

PURPOSE: To compare the accuracy of ultrasonography (US), single-energy CT (SECT), dual-energy CT (DECT), MR imaging (MRI), and MR spectroscopy (MRS) for detecting fatty liver in a rat model. MATERIALS AND...
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Cryotherapy in Dermatology

Kang HK, Chu H, Kim DY

Cryotherapy is one of the most widely used procedures in the field of dermatology. Since the development of cryotherapy with the use of liquid nitrogen beginning in the 19(th) century,...
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Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance

Kim YJ, Park S, Premaratna R, Selvaraj S, Park SJ, Kim S, Kim D, Kim MS, Shin DH, Choi KC, Kwon SH, Seo W, Lee NT, Kim SH, Kang HK, Kim YW

Diagnosis of scrub typhus is challenging due to its more than twenty serotypes and the similar clinical symptoms with other acute febrile illnesses including leptospirosis, murine typhus and hemorrhagic fever...
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STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9

Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC

PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling...
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Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review

Baek BH, Kim SK, Yoon W, Heo TW, Lee YY, Kang HK

Chlorfenapyr is a widely used, moderately hazardous pesticide. Previous reports have indicated that chlorfenapyr intoxication can be fatal in humans. We reported the first non-fatal case of chlorfenapyr-induced toxic leukoencephalopathy...
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