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Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy

Kim K, Jeong W, Jun IG, Park JY

Background: Studies investigating the correlation between spinal adenosine A1 receptors and vincristine-induced peripheral neuropathy (VIPN) are limited. This study explored the role of intrathecal N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) in the rat...
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Cerebral air embolism and subsequent transient neurologic abnormalities in a liver transplant recipient following the removal of the pulmonary artery catheter from the central venous access device: a case report

Kim SK, Jun IG, Jang DM, Lim J, Hwang GS, Kim YK

Cerebral air embolism is a rare but potentially life-threatening complication. We experienced a living-donor liver transplant recipient who presented with unexpected cerebral air embolism and transient neurologic abnormalities that subsequently...
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Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation

Choi YS, Jun IG, Kim SH, Park JY

PURPOSE: Lamotrigine, a novel anticonvulsant, is a sodium channel blocker that is efficacious in certain forms of neuropathic pain. Recently, microglial and astrocytic activation has been implicated in the development...
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Intrathecal Gabapentin Increases Interleukin-10 Expression and Inhibits Pro-Inflammatory Cytokine in a Rat Model of Neuropathic Pain

Lee BS, Jun IG, Kim SH, Park JY

We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat...
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Intrathecal Lamotrigine Attenuates Antinociceptive Morphine Tolerance and Suppresses Spinal Glial Cell Activation in Morphine-Tolerant Rats

Jun IG, Kim SH, Yoon YI, Park JY

Glial cells play a critical role in morphine tolerance, resulting from repeated administration of morphine. Both the development and the expression of tolerance are suppressed by the analgesic lamotrigine. This...
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Interaction of Morphine and Selective Serotonin Receptor Inhibitors in Rats Experiencing Inflammatory Pain

Lee BS, Jun IG, Kim SH, Park JY

Citalopram and paroxetine are selective serotonin reuptake inhibitors and also have antinociceptive effects. We investigated the antiallodynic and antihyperalgesic effects of intrathecally administered morphine, citalopram, paroxetine, and combinations thereof, in...
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Central venous catheter-related superior vena cava syndrome following renal transplantation: A case report

Seo M, Shin WJ, Jun IG

A 55-year-old man with end-stage renal disease had severe left ventricular dysfunction and a history of deep vein thrombosis. He underwent renal transplantation, during which a central venous catheter was...
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A Study on Nursing Students' Job-esteem, Work Values, and Satisfaction of Their Major

Son BH, Kim YM, Jun IG

  • KMID: 2270566
  • Korean J Occup Health Nurs.
  • 2011 Nov;20(3):240-249.
PURPOSE: The purpose of this study was to identify the factors influencing the nursing students' job-esteem. METHODS: The data were collected from March 1 to 30, 2011 using questionnaires. The subjects...
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Increased intracranial pressure after massive blood loss: A case report

Park JH, Jun IG, Son HJ, Gwak M

  • KMID: 2169233
  • Anesth Pain Med.
  • 2010 Apr;5(2):166-168.
A 4-year old boy with supravalvular ascending aortic stenosis underwent sliding aortoplasty. After cardiopulmonary bypass weaning, aorta suture site was torn accidentally and the patient was in hypovolemic shock. Emergency...
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Effect of intrathecal oxcarbazepine on rat tail flick test-determined morphine tolerance

Jun IG, Park JY, Choi YS, Im SH

BACKGROUND: Repeated administration of morphine leads to characteristic tolerance. We tested the effects of intrathecal oxcarbazepine (OXC) on spinal morphine tolerance in rats using the tail flick test. METHODS: Sprague-Dawley...
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Intrathecal lamotrigine blocks and reverses antinociceptive morphine tolerance in rats

Jun IG, Park JY, Choi YS, Kim TH

BACKGROUND: Chronic administration of morphine leads to the development of tolerance. We investigated the effects of intrathecal lamotrigine on the spinal morphine tolerance in rats that are undergoing tail flick...
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The Antiallodynic Effects of Intrathecal Zaprinast in Rats with Chronic Constriction Injury of the Sciatic Nerve

Lee JD, Jun IG, Choi YS, Im SH, Park JY

BACKGROUND: Zaprinast is an inhibitor of phosphodiesterase 5, 6 and 9. Phosphodiesterase inhibitors could produce anti-nociceptive effects by promoting the accumulation of cGMP. We hypothesized that intrathecal zaprinast could attenuate...
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Measurement of respiratory pulse transit time variation as an intravascular volume index in simulated hemorrhage

Jun IG, Park JY, Sang BH, Park JY, Joo JY, Hwang GS

BACKGROUND: We examined the usefulness of respiratory pulse transit time (PTT) variation as an intravascular volume index in young, healthy, spontaneous, paced breathing volunteers exposed to simulated central hypovolemia by...
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The Interaction of Gabapentin and N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on Mechanical Allodynia in Rats with a Spinal Nerve Ligation

Park JY, Jun IG

We examined the antiallodynic interaction between gabapentin and adenosine A1 receptor agonist, N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA), in a rat model of nerve ligation injury. Rats were prepared with ligation of left...
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The interaction of morphine and selective serotonin reuptake inhibitors on mechanical allodynia in rats with a spinal nerve ligation

Kwon MY, Jun IG, Kim TH, Park JY

BACKGROUND: Nerve injury may produce a tactile allodynia. However, there are few reports regarding the interaction of morphine and selective serotonin reuptake inhibitors (SSRIs) during a neuropathic pain state. Therefore,...
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Inadvertent Breakage of the Spinal Needle during the Obturator Nerve Block for the Transurethral Resection of Bladder Tumor: A case report

Chin JH, Jun IG, Kim YK, Kang KN, Hwang GS, Hwang JH

Obturator nerve block is occasionally performed during transurethral resection of lateral bladder wall tumors to prevent the violent contraction of the adductor muscle of the thigh. Rare complications including intravascular...
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The Effects of Intrathecal Adenosine A1 Receptor Agonists (R-PIA) on the Morphine Tolerance in a Rat Model of Postoperative Pain

Jun IG, Piao LZ, Kwon MY, Park JY

BACKGROUND: Analgesic tolerance to opioids has been described in both experimental and clinical conditions, which may limit their clinical utility. This study investigated the effects of intrathecal adenosine...
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Anesthetic Experience of Percutaneous Nephrolithotomy for Renal Calculi in a Patient with Lesch-Nyhan Syndrome: A case report

Jun IG, Chin JH, Kim YK, Kim YU, Cho SK, Hwang GS, Hwang JH

Lesch-Nyhan syndrome (LNS) is a rare, X-linked recessive inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine-phophoribosyltransferase, leading to excessive purine production and elevation of uric acid. Clinical manifestations...
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Assessment of the Mechanism of Arterial Blood Pressure Change during Sevoflurane Induction: Beat-to-Beat Analysis of Hemodynamic Variables Using a Modelflow Method

Kim YK, Youn MO, Seo HS, Choi JH, Choi BM, Shin WJ, Do KJ, Cho SJ, Kang SJ, Jun IG, Song JG, Huh IY, Hwang GS

BACKGROUND: A modelflow method provides beat-to-beat analysis of cardiovascular variables based on arterial pulse pressure analysis. In this study, we assessed the mechanism of arterial blood pressure (ABP) change during...
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Assessment of Cardiovascular Autonomic Function in Patients with Liver Cirrhosis Using Heart Rate Variability, Blood Pressure Variability and Baroreflex Sensitivity

Youn MO, Kang SJ, Jun IG, Shin WJ, Choi BM, Do KJ, Cho SJ, Choi JH, Song JG, Huh IY, Kim YK, Hwang GS

BACKGROUND: Liver cirrhosis is associated with several hemodynamic abnormalities, including an impairment of autonomic nervous system reflexes, but very few have compared the disease severity with cardiovascular autonomic dysfunction assessed...
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