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Aberrant Promoter Methylation of the Vimentin Gene in Colorectal Cancer Associated with the Adenoma-Carcinoma Sequence

Cho MH, Lee YM, Kim JS, Kim HS, Lee KH, Juhng SW, Lee JH

  • KMID: 2277607
  • Korean J Pathol.
  • 2010 Apr;44(2):179-186.
BACKGROUND: DNA hypermethylation is a common epigenetic finding in human cancers and is closely associated with transcriptional silencing. In the present study, we investigated the proportion of colorectal neoplasms that...
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Type 3 Repeats of Thrombospondin-2 Increases Metastasis in Mouse Colorectal Cancer CT-26 Cells

Jin Z, Kim YJ, Park YK, Choi YD, Lee JH, Lee D, Choi CY, Juhng SW, Choi C

Thrombospondins (TSPs) are secreted multimeric glycoproteins that modulate extracellular matrix structure and cell behaviour. TSPs are involved in platelet aggregation, cell adhesion, migration, angiogenesis, wound healing, and proliferation. The purpose...
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Cytologic Diagnosis of Malignant Pleural Effusion in Multiple Myeloma: Two Case Reports

Choi YD, Kim SS, Han CW, Lee JS, Nam JH, Juhng SW, Choi C

  • KMID: 2459602
  • Korean J Pathol.
  • 2009 Aug;43(4):382-385.
Malignant pleural effusion in multiple myeloma (MM) is extremely rare and is associated with poor prognosis. We experienced two cases of MM IgA type with malignant pleural effusion. The diagnoses...
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Analysis of HPV-other Samples by Performing HPV DNA Sequencing

Choi YD, Han CW, Chung WJ, Jung WW, Lee JS, Nam JH, Lee MC, Juhng SW, Choi HS, Park CS

  • KMID: 1979343
  • Korean J Pathol.
  • 2009 Jun;43(3):250-253.
BACKGROUND: HPV-other samples are designated as being positive on HPV-PCR, but negative when using specific HPV hybridization probes. We wanted to determine the types on the HPV-other samples by performing...
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DNA Methylation Profiles of MGMT, DAPK1, hMLH1, CDH1, SHP1, and HIC1 in B-Cell Lymphomas

Kim SS, Choi YH, Han CW, Choi YD, Park Y, Lee JJ, Kim HJ, Lee IK, Lee JS, Juhng SW, Choi C

BACKGROUND: This study was designed to examine the prevalence of aberrant promoter methylation in a selected panel of genes potentially involved in lymphoid tumors. METHODS: The promoter hypermethylation status of MGMT,...
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Association Study of hMLH1 Polymorphisms with Riskof Acute Myeloid Leukemia in Korean

Piao CZ, Mei JX, Kim HJ, Juhng SW, Choi C

Acute myelogenous leukemia (AML) is caused by dysregulation of oncogenes, tumor suppressor genes, and DNA mismatch repair genes. Accumulating evidence has shown that genetic differences in mismatch repair capacity resulting...
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Therapeutic Effects of 1% Cyclosporin A Eyedrops on Herpetic Stromal Keratitis

Lee KH, Park CS, Juhng SW, Woo JM, Park YG, Yoon KC

We evaluated the therapeutic effects of topical administration of 1% cyclosporin A on herpetic stromal keratitis. Sixteen eyes of 16 patients with non-necrotizing herpetic stromal keratitis were divided into two...
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Solitary Splenic Metastases from Uterine Cervical Cancer: Case Reports and Review of the Literature

Kim JH, Choi YD, Lee JH, Nam JH, Juhng SW, Koh YS, Cho CK, Choi C

  • KMID: 1163224
  • Korean J Pathol.
  • 2008 Oct;42(5):317-322.
Splenic metastasis from gynecologic tumors is extremely rare, especially in the absence of apparent disease at other sites. We report two patients that underwent splenectomy for a solitary splenic metastasis...
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An Immunohistochemical Study of Angiogenesis in Tumor Emboli

Kim JH, Choi C, Lee JH, Lee JS, Kim SS, Han CW, Juhng SW

  • KMID: 1521640
  • Korean J Pathol.
  • 2007 Aug;41(4):252-257.
BACKGROUND: Angiogenesis, which is essential for tumor growth, is known to occur in the extravascular stroma. However, vascular structures were noted in intravascular tumor emboli in surgical specimens. This prompted...
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Claudin-7 is Highly Expressed in Chromophobe Renal Cell Carcinoma and Renal Oncocytoma

Choi YD, Kim KS, Ryu S, Park Y, Cho NH, Rha SH, Jang JJ, Ro JY, Juhng SW, Choi C

Claudin-7 has recently been suggested to be a distal nephron marker. We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from...
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Tetranucleotide Repeat Microsatellite Instability in Uterine Cervical Carcinomas

Choi YD, Lee JS, Choi C, Park CS, Juhng SW, Choi HS, Nam JH

  • KMID: 1521692
  • Korean J Pathol.
  • 2007 Feb;41(1):30-37.
BACKGROUND: Elevated levels of microsatellite alterations at selected tetranucleotide repeat regions (EMAST) have been recently described, and they are a distinct type of microsatellite instability (MSI). We investigated the prevalence...
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Expression of VEGF, MMP-9 and Neovascularization in Relationship to the Clinical Behavior of Giant Cell Tumors of Bone

Lee KH, Kim JH, Shim MK, Han CW, Kim SS, Juhng SW, Jung ST, Lee JH

  • KMID: 1593778
  • Korean J Pathol.
  • 2006 Dec;40(6):420-426.
BACKGROUND: Giant cell tumors (GCT(s)) of bone are benign but can be locally aggressive neoplasms. Their clinical behavior has been difficult to predict on the basis of histology alone....
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Relationship between Chromatin Pattern of Tumor Cell Nuclei and Transcriptional Sites

Juhng SW

  • KMID: 2172304
  • Chonnam Med J.
  • 2005 Dec;41(3):253-258.
Malignant cell nuclei, in general, have increased amount of heterochromatin and decreased electron density of euchromatin, making the chromatin pattern coarser than that of benign cell nuclei. Chromatin pattern in...
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A Case of Osteoid Osteoma of the Finger Bone

Lee JH, Jung ST, Lee KH, Kim HJ, Oh HS, Choi YD, Nam JH, Choi C, Juhng SW

  • KMID: 1613962
  • Chonnam Med J.
  • 2003 Sep;39(3):182-184.
The occurrence of osteoid osteoma in the hand is rare. Recently we examined a case of osteoid osteoma of distal phalanx of the middle finger in a twenty-year-old man. This...
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Metastatic Anaplastic Carcinoma of the Small Intestine Arising from The Lung

Kim DY, Joo JK, Ryu SY, Kim YJ, Kim SK, Juhng SW

  • KMID: 1972906
  • Cancer Res Treat.
  • 2003 Aug;35(4):364-366.
A metastatic carcinoma of the small intestine is rare. Here, the case study of an 80-year-old lung carcinoma patient, with generalized peritonitis due to neoplastic perforation of the small intestine...
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Clonal Analysis of Neurofibroma by PCR Amplification of HUMARA Gene

Lee JH, Han SS, Oh HS, Choi YD, Kim HJ, Lee KH, Nam JH, Choi C, Juhng SW

  • KMID: 1979371
  • Korean J Pathol.
  • 2003 Dec;37(6):421-428.
BACKGROUND: While neurofibromas have generally been regarded as polyclonal hyperplastic lesions, it remains unclear whether the tumor is a true neoplasm or a hyperplastic lesion. METHODS: Determination of clonality by...
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Clonality Study in Carcinosarcomas and Malignant Mixed Epithelial Tumors

Park EJ, Choi YD, Nam JH, Lee MC, Park CS, Juhng SW, Choi IS, Kim KH, Choi C

  • KMID: 1725907
  • Korean J Pathol.
  • 2002 Aug;36(4):205-211.
BACKGROUND: Tumors are usually considered to be clonal progeny of single transformed cells. Carcinosarcomas and malignant mixed epithelial tumors are examples where controversies exist regarding the singularity or multiplicity of...
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Clonality Assay of Dysplastic Epithelial Lesions of the Stomach

Choi HS, Kim MS, Park JW, Park CS, Kim YJ, Juhng SW

  • KMID: 2372683
  • J Korean Gastric Cancer Assoc.
  • 2001 Sep;1(3):129-135.
PURPOSE: Dysplasia or flat adenoma of the stomach is regarded as a precancerous lesion. However, the frequency and the evolutionary process of malignant transformation of gastric dysplasia are still debated....
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In Situ Detection of mRNA and RNA Component of Human Telomerase in Proliferative Lesions of the Stomach

Kim MS, Juhng SW

  • KMID: 1725817
  • Korean J Pathol.
  • 2001 Aug;35(4):299-305.
BACKGROUND: Proliferative lesions of the stomach were investigated by in situ hybridization using RNA probes for telomerase components and compared with the results by TRAP (telomeric repeat amplification protocol) assay....
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mRNA is Synthesized Mainly at the Phase between the Euchromatin and Heterochromatin: Proposal of a Phase Theory

Kim MS, Juhng SW

  • KMID: 2275638
  • Korean J Pathol.
  • 2001 Apr;35(2):93-97.
BACKGROUND: Malignant cell nuclei, in general, have increased amounts of heterochromatin and decreased electron densities of euchromatin, making the chromatin pattern coarser than that of benign cell nuclei. The...
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