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Long-term Renal Outcome of Biopsy-proven Acute Tubular Necrosis and Acute Interstitial Nephritis

Kim H, Jo SK, Ahn SY, Kwon YJ, Lee H, Oh J, Chin HJ, Lim K, Lee J, Yang J, Kim MG, Cho WY, Oh SW

Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), long-term renal outcome of AKI still remains unclear. Acute tubular necrosis (ATN) is the most...
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Pathogens of peritoneal dialysis peritonitis: Trends from a single-center experience over 15 years

Hwang TY, Kim MG, Oh SW, Jo SK, Cho WY, Yang J

Background: Concerns are increasing about the emergence of pathogens with antibiotic resistance in peritoneal dialysis (PD) peritonitis. We investigated the current pathogen trends and risk factors in PD peritonitis. Methods: We...
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Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury

Cho WY, Lim SY, Yang JH, Oh SW, Kim MG, Jo SK

Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3...
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2019 Tabletop Exercise for Laboratory Diagnosis and Analyses of Unknown Disease Outbreaks by the Korea Centers for Disease Control and Prevention

Kim IH, Jang JH, Jo SK, No JS, Seo SH, Kim JY, Jung SO, Kim JM, Lee SE, Park HK, Kim EJ, Jeon JH, Choi MM, Ryu By, Jang YS, Kim Hm, Lee J, Shin SH, Kim HK, Kim EK, Park YE, Yoo CK, Lee SW, Han MG, Rhie GE, Kang BH

Objectives: The Korea Centers for Disease Control and Prevention has published “A Guideline for Unknown Disease Outbreaks (UDO).” The aim of this report was to introduce tabletop exercises (TTX) to...
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Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome

Lee H, Kang E, Kang HG, Kim YH, Kim JS, Kim HJ, Moon KC, Ban TH, Oh SW, Jo SK, Cho H, Choi BS, Hong J, Cheong HI, Oh D

Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of endothelial cell damage, as well as the resulting ischemic end-organ injuries. A...
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Retroperitoneal fibrosis in the era of immunoglobulin G4-related disease

Choi YK, Yang JH, Ahn SY, Ko GJ, Oh SW, Kim MG, Cho WY, Jo SK

BACKGROUND: Retroperitoneal fibrosis (RPF) is a rare disease characterized by fibroinflammatory tissue in the periaortic or periiliac retroperitoneum, where it frequently encases ureters. There is emerging evidence that a subset...
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Diastolic dysfunction and acute kidney injury in elderly patients with femoral neck fracture

Cho W, Hwang TY, Choi YK, Yang JH, Kim MG, Jo SK, Cho WY, Oh SW

BACKGROUND: Femoral neck fracture is common in the elderly population. Acute kidney injury (AKI) is an important risk factor for mortality in patients who have had such fracture. We evaluated...
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The role of senescence of bone marrow cells in acute kidney injury

Lee J, Ko YS, Lee HY, Yang J, Oh S, Jo SK, Cho W, Kim MG

BACKGROUND: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes....
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Three Streams for the Mechanism of Hair Graying

Jo SK, Lee JY, Lee Y, Kim CD, Lee JH, Lee YH

Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and...
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Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury

Kim SC, Ko YS, Lee HY, Kim MG, Jo SK, Cho WY

BACKGROUND/AIMS: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of...
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Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury

Cho W, Song JY, Oh SW, Kim MG, Ko YS, Lee HY, Jo SK

Effective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils...
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Predictive factors of acute kidney injury in patients undergoing rectal surgery

Lim SY, Lee JY, Yang JH, Na YJ, Kim MG, Jo SK, Cho WY

BACKGROUND: Despite major advance in surgical techniques from open surgery to robot-assisted surgery, acute kidney injury (AKI) is still major postoperative complication in rectal surgery. The purpose of this study...
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Risk factors and outcomes of acute renal infarction

Yang J, Lee JY, Na YJ, Lim SY, Kim MG, Jo SK, Cho W

BACKGROUND: Renal infarction (RI) is an uncommon disease that is difficult to diagnose. As little is known about clinical characteristics of this disease, we investigated its underlying risk factors and...
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Cardiorenal Syndrome

Jo SK

Although combined cardiac and renal dysfunction is common in hospitalized patients and portends a poor prognosis, lack of understanding of the pathogenesis and classification of the condition has hampered the...
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Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea

Cheong HI, Jo SK, Yoon SS, Cho H, Kim JS, Kim YO, Koo JR, Park Y, Park YS, Shin JI, Yoo KH, Oh D

Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by micro-angiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The major pathogenesis of aHUS involves dysregulation of the complement system....
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Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection

Kim SC, Seo MY, Lee JY, Kim KT, Cho E, Kim MG, Jo SK, Cho WY, Kim HK

BACKGROUND/AIMS: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C....
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Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury

Seo MY, Yang J, Lee JY, Kim K, Kim SC, Chang H, Won NH, Kim MG, Jo SK, Cho W, Kim HK

BACKGROUND/AIMS: The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated in animal models. However, to date, there have been no human studies investigating the...
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Intra-abdominal hypertension does not predict renal recovery or in-hospital mortality in critically ill patients with acute kidney injury

Chang HJ, Yang J, Kim SC, Kim MG, Jo SK, Cho WY, Kim HK

BACKGROUND: Although emerging evidence suggests that intra-abdominal hypertension (IAH) is a predictor of the development of acute kidney injury (AKI), it remains unclear whether the presence of IAH is a...
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Relationship between pulmonary hypertension, peripheral vascular calcification, and major cardiovascular events in dialysis patients

Kim SC, Chang HJ, Kim MG, Jo SK, Cho WY, Kim HK

BACKGROUND: Pulmonary hypertension (PHT) is a recently recognized complication of chronic kidney disease. In this study, we investigated the association between PHT, peripheral vascular calcifications (VCs), and major cardiovascular events. METHODS:...
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Etiology and outcomes of anuria in acute kidney injury: a single center study

Choi HM, Kim SC, Kim MG, Jo SK, Cho WY, Kim HK

BACKGROUND: It was previously known that anuric acute kidney injury (AKI) is uncommon and its occurrence suggests complete ureteral obstruction, shock, or a major vascular event. As the epidemiology of...
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