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Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells

Hwang JJ, Ko IG, Jin JJ, Hwang L, Kim SH, Jeon JW, Paik SS, Chang BS, Choi CW

Purpose: Acute respiratory distress syndrome (ARDS) is characterized by its acute onset of symptoms such as bilateral pulmonary infiltrates, severe hypoxemia, and pulmonary edema. Many patients with ARDS survive in...
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Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH

PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic...
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Effect of Polydeoxyribonucleotide on Lipopolysaccharide and Sevoflurane-Induced Postoperative Cognitive dysfunction in Human Neuronal SH-SY5Y Cells

Jeong H, Chung JY, Ko IG, Kim SH, Jin JJ, Hwang L, Moon EJ, Lee BJ, Yi JW

PURPOSE: Postoperative cognitive dysfunction (POCD) is a complication of surgery characterized by acute cognitive dysfunction, memory impairment, and loss of attention. The effect of polydeoxyribonucleotide (PDRN) on the POCD environment...
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Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats

Ko IG, Hwang L, Jin JJ, Kim SH, Han JH, Jeon JW, Cho ST

PURPOSE: Benign prostatic hyperplasia (BPH) impacts quality of life in men by causing lower urinary tract symptoms. α1-Adrenoceptor (α1-AR) blockers improve lower urinary tract symptoms. We investigated the efficacy of...
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Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice

Moon EJ, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, An H, Lee BJ, Yi JW

PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep...
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Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats

Park JH, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, Yoon SH, Hong J, Chung JY, Lee DW

PURPOSE: Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults. We...
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Pentoxifylline Alleviates Perinatal Hypoxic-Ischemia-Induced Short-term Memory Impairment by Suppressing Apoptosis in the Hippocampus of Rat Pups

Park JH, Kim SE, Jin JJ, Choi HS, Kim CJ, Ko IG

PURPOSE: Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurologic morbidity in infants and children. We investigated the effects of pentoxifylline, a methylxanthine derivative and...
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Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

Ko IG, Moon BM, Kim SE, Jin JJ, Hwang L, Ji ES, Kim CJ, Kim TH, Choi HH, Chung KJ

PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The...
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Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice

Hwang DS, Kwak HB, Ko IG, Kim SE, Jin JJ, Ji ES, Choi HH, Kwon OY

PURPOSE: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function...
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Aerobic Exercise Affects Myostatin Expression in Aged Rat Skeletal Muscles: A Possibility of Antiaging Effects of Aerobic Exercise Related With Pelvic Floor Muscle and Urethral Rhabdosphincter

Ko IG, Jeong JW, Kim YH, Jee YS, Kim SE, Kim SH, Jin JJ, Kim CJ, Chung KJ

  • KMID: 2232928
  • Int Neurourol J.
  • 2014 Jun;18(2):77-85.
PURPOSE: Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction,...
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A comparative trial of Nalador and mechanical stimulation(Metreurynter) in the termination of midtrimester pregnancy

Jin JJ, Chang EJ, Lee JS, Jin K, Kim DJ

  • KMID: 1696918
  • Korean J Obstet Gynecol.
  • 1992 May;35(5):682-693.
No abstract available.
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